Results 61 to 70 of about 1,362 (166)

Evaluation of conductivity tensor image along the perivascular space in the brains of patients with cognitive impairments

Frontiers in Aging Neuroscience
BackgroundThe diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index has been proposed as an imaging marker of impaired perivascular water transport across the Alzheimer’s disease (AD) continuum. Whether a conductivity-based ALPS
Jehyeuk Ahn, Sang-Young Kim, Mun Bae Lee, Oh-In Kwon, Hak Young Rhee, Yu Jin Jung, Yoon Kim, Soonchan Park, Chang-Woo Ryu, Jinseok Lee, Geon-Ho Jahng   +10 more
doaj   +1 more source

Interview with Ruotong Chen, recipient of the 2026 Epilepsia Open Prize for Clinical Research

Epilepsia Open, Volume 11, Issue 5, Page 1880-1882, October 2026.
Merab Kokaia, Piero Perucca
wiley   +1 more source

Diffusion along perivascular spaces as a marker for Glymphatic system impairment in spinocerebellar Ataxia type 3

Neurobiology of Disease
Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder characterized by the accumulation of polyglutamylated ATXN3 protein within neurons, which can potentially compromise the integrity of the brain's glymphatic system.
Xiao-Yue Xia, Zi-Qiang Huang, Hao-Hang Lin, Zhen-Yi Liu, Lin Zhang, Meng-Cheng Li, Yu-Qin Tu, Na-Ping Chen, Jun Ni, Qun-Lin Chen, Jian-Ping Hu, Shi-Rui Gan, Xin-Yuan Chen   +12 more
doaj   +1 more source

Association of glymphatic system dysfunction with cognitive impairment in temporal lobe epilepsy

Frontiers in Aging Neuroscience
ObjectivesTo explore the relationship between glymphatic dysfunction and cognitive impairment in unilateral temporal lobe epilepsy (TLE).MethodsThis study retrospectively included 38 patients with unilateral TLE and 26 age- and gender-matched healthy ...
Jiajia Wang, Xiaona Xia, Bin Zhang, Xiaotian Ma, Feng Shi, Ying Wei, Ling Li, Xiangshui Meng   +7 more
doaj   +1 more source

Multimodal neuroimaging of brain microstructure and hippocampal morphology alterations in type 2 diabetes mellitus

Scientific Reports
Type 2 diabetes affects the central nervous system, yet the role of glymphatic dysfunction remains unclear. This study investigated alterations in the DTI-ALPS index in T2DM patients and its associations with cognitive function, white matter integrity ...
Mengyuan Li, Lin Yao, Zhen Zhong, Haipeng Huang, Yanglan Li, Haizhu Zheng, Hongfeng Wang   +6 more
doaj   +1 more source

Does G‐ALPS measure glymphatic function? Revisiting construct validity in diffusion‐based glymphatic imaging

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Einstein Francisco Camargos, Raphael Lopes Olegário, Otávio Toledo Nóbrega   +2 more
wiley   +1 more source

Glymphatic system dysfunction in recovered patients with mild COVID-19: A DTI-ALPS study

iScience
Central nervous sequelae are often reported in recovered patients with COVID-19. It is not clear whether recovered COVID-19 patients have glymphatic impairment and clinical correlation. In this study, we demonstrated that mild COVID-19 patients experienced asymmetric bilateral glymphatic function decline after four months of recovery, and the decrease ...
Lin Wu, Zhi Zhang, Xiao Liang, Yao Wang, Yuan Cao, Meng Li, Fuqing Zhou   +6 more
openaire   +3 more sources

Abnormally glymphatic system functional in patients with migraine: a diffusion kurtosis imaging study

The Journal of Headache and Pain
Background The diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) method has been used to evaluate glymphatic system function in patients with migraine.
Yungang Cao, Mei Huang, Fangwang Fu, Keyang Chen, Kun Liu, Jinming Cheng, Yan Li, Xiaozheng Liu   +7 more
doaj   +1 more source

Neuroanatomical substrates of perivascular space index: a morphometric and tractography study

Frontiers in Psychiatry
Background and objectivesThe diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is an important imaging biomarker for assessing glymphatic system function.
Xuyang Wang, Qin Zhang, Qin Zhang, Peitao Su, Peitao Su, Wenjing Lu, Wenjing Lu, Guoqiang Chen, Ping Cui, Mao Sheng, Shiwu Yin, Shiwu Yin   +11 more
doaj   +1 more source

Changes in DTI-ALPS index and its associations with neuronal damage in Lewy body disease

Parkinsonism & Related Disorders
Dysfunction of the glymphatic system is thought to lead to build up of toxic proteins including β-amyloid and α-synuclein, and thus may be involved in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). The Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS) index has been proposed as a marker of glymphatic function.To ...
M.J. Firbank, P.C. Donaghy, L.M. Allan, N. Barnett, S.H. Barker, J. Ciafone, R. Durcan, G. Greenfinch, C.A. Hamilton, K. Olsen, G. Petrides, A.J. Thomas, J.T. O'Brien, J.-P. Taylor   +13 more
openaire   +2 more sources