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Evaluation and Interpretation of DTI-ALPS, a Proposed Surrogate Marker for Glymphatic Clearance, in a Large Population-Based Sample

Alzheimer's Research and Therapy
Background The diffusion tensor imaging along perivascular spaces index (DTI-ALPS), which measures diffusivity in the perivascular spaces along the medullary veins, has gained popularity and controversy as a surrogate marker of glymphatic clearance.
Petrice M Cogswell, Sheelakumari Raghavan, Scott A Przybelski   +2 more
exaly   +2 more sources

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Reduced DTI-ALPS index in tinnitus patients: DTI-ALPS as a mediator of sleep on tinnitus

Neuroradiology
Sleep disturbance is a common comorbidity in tinnitus patients, which may be attributed to changes in brain structure and function. The aim of this study was to explore the potential role of the glymphatic system (GS), a recently discovered pathway for brain waste clearance, in tinnitus and the associated sleep disturbance.The DTI-ALPS index of 22 ...
Yinfei Liang, Hui-quan Wen, Ruo-mi Guo, Gen-di Yin, Jian-qi Zhao, Zhi-cheng Li, Xiang-li Zeng   +6 more
openaire   +2 more sources

APOE4 Modulates the Association Between DTI-ALPS Index and Alzheimer's Pathologies

Alzheimer's and Dementia
Abstract INTRODUCTION Diffusion‐tensor imaging (DTI) analysis along the perivascular space (ALPS) has emerged as a non‐invasive marker of glymphatic function. Preclinical studies suggest that apolipoprotein E4 ( APOE 4), a major
Kang, Koung Mi, Park, Chanrim, Byun, Min Soo, Yi, Dahyun, Nam, Hyeryeong, Ryu, Jiin, Jung, Joon Hyung, Jung, Gijung, Ahn, Hyejin, Lee, Jun‐Young, Lee, Yun‐Sang, Kim, Yu Kyeong, Sohn, Chul‐Ho, Lee, Dong Young   +13 more
exaly   +3 more sources

Evaluation of the Glymphatic System Using the DTI-ALPS Index in Patients with Glioma

ISMRM Annual Meeting
We evaluated the function of the human glymphatic system (GS) in patients with glioma using diffusion tensor imaging analysis along with the perivascular space (DTI-ALPS). Thirty-seven patients with glioma and 34 healthy controls (HCs) were recruited for analysis.
Chao Zhang, Ruohan Li, Jingyun Sha, Lulu Cai, Peng Wu, Kai Xu   +5 more
openaire   +1 more source

Validation of Automated DTI-ALPS and Free Water Index as Potential Survival Stratification Markers in IDH-Wildtype Glioblastoma

Neuroradiology
Abstract Purpose Diffusion MRI–based indirect indices of neurofluid dynamics, such as diffusion tensor imaging along the perivascular space (DTI-ALPS) and extracellular free water (FW), have been reported to have prognostic implications in glioblastoma.
Seung Hong Choi, Chul-Kee Park, Minchul Kim   +2 more
exaly   +3 more sources

Impaired Glymphatic System Function in Sleep-Deprived Individuals demonstrated by DTI-ALPS Index

ISMRM Annual Meeting
Motivation: Sleep Deprivation is characterized by partial or total loss of normal sleep due to various reasons, has emerged as a social public health problem. Goal(s): To evaluate the alterations of glymphatic function in patients with sleep deprivation.
Yilei Zhao, Xijian Dai, Wenjun Huang, Lu Han, Peng Wu, Wenbo Xiao   +5 more
openaire   +1 more source

Predictive Value of the Combined DTI-ALPS Index and Serum Creatinine Levels in Mild Cognitive Impairment in Parkinson’s Disease

Frontiers in Neurology
ObjectiveTo identify independent risk factors for Parkinson disease mild cognitive impairment (PD-MCI) and develop a prediction model integrating clinical indicators, blood biomarker, and neuroimaging data, aiding in detection and intervention.MethodsA retrospective study was conducted with 150 PD patients.
Pin Meng, Bingchao Xu, Niu Ji
exaly   +3 more sources

Evaluation of the Glymphatic System Using the DTI-ALPS Index in Patients with Spontaneous Intracerebral Haemorrhage

ISMRM Annual Meeting
We evaluated the function of the human glymphatic system (GS) in patients with spontaneous intracerebral haemorrhage (sICH) using diffusion tensor imaging analysis along with the perivascular space (DTI-ALPS). Twenty patients with sICH and 31 healthy controls (HCs) were recruited for analysis.
Chao Zhang, Jingyun Sha, Lulu Cai, Houliang Zhao, Weiqiang Dou, Kai Xu   +5 more
openaire   +1 more source

Impaired glymphatic system function in individuals with Alzheimer's disease demonstrated by DTI-ALPS index

ISMRM Annual Meeting
Motivation: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that primarily affects the brain and leads to diffusion impairment. Goal(s): To evaluate the alterations of glymphatic function in AD and explore its association with cognition and blood biomarkers.
Xiaohan Mao, Zhongzheng Jia, Lu Han
openaire   +1 more source

Alterations in the DTI-ALPS Index and Choroid Plexus Volume Are Associated With Clinical Symptoms in Participants With Narcolepsy Type 1

Sleep Medicine
Narcolepsy type 1 (NT1) is a sleep disorder characterized by excessive daytime sleepiness accompanied by cataplexy. Sleep disorders have been shown to affect the glymphatic system. This study aimed to evaluate changes in the diffusion tensor imaging along the perivascular space (DTI-ALPS) index and choroid plexus (CP) volume in NT1 participants, and to
Xihai Zhao, Liang Xie, Jiankun Dai
exaly   +3 more sources