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Harmonization of the multisite ALPS-index based on DTI-ALPS using the combined association test

ISMRM Annual Meeting
Diffusion tensor image analysis along the perivascular space (DTI-ALPS) is a promising noninvasive method for indirectly evaluating the glymphatic system. However, the ALPS-index calculated from diffusion MRI data collected at multiple sites should be harmonized to avoid site-related effects.
Yuya Saito   +17 more
openaire   +1 more source

DTI-ALPS index mediates the relationship between childhood trauma and antidepressant response in major depressive disorder

Journal of Affective Disorders
Impaired glymphatic function may mediate the impact of childhood trauma on antidepressant response, but this relationship remains unclear. This study examined whether glymphatic function mediates the association between childhood trauma and antidepressant response in major depressive disorder (MDD).We included 104 MDD patients receiving selective ...
Cuicui, Li   +8 more
openaire   +2 more sources

Obesity, White Matter Hyperintensities, and Cognitive Decline: Sex-Specific DTI-ALPS Index Mediation

Stroke
BACKGROUND: Obesity is a risk factor for white matter hyperintensities (WMH) and cognitive decline, but underlying mechanisms regarding sex differences, obesity metrics, and the glymphatic system remain unclear.
Lusen Ran   +14 more
openaire   +1 more source

White matter and glymphatic system alterations in patients with focal epilepsy: insights from PSMD and DTI-ALPS index

Neuroradiology
Peak width of skeletonized mean diffusivity (PSMD) is a neuroimaging biomarker of white matter integrity in cerebral small-vessel disease. However, the significance of PSMD in focal epilepsy remains unclear. This study aimed to investigate alterations in white matter microstructure and glymphatic system function in patients with focal epilepsy by ...
Ho-Joon, Lee   +2 more
openaire   +2 more sources

The relationship between choroid plexus volume, DTI-ALPS index, kidney function, and amyloid pathology in alzheimer’s disease

Neuroradiology
To explore the effect of the choroid plexus volume (CPV) changes on paravascular drainage function, Alzheimer's disease (AD) pathology, and the kidney-brain axis in AD.A total of 74 AD patients and 32 healthy controls (HC) were included for this study, and cerebrospinal fluid (CSF) AD biomarker data and serum creatinine levels were collected from 28 AD
Lefan, Yu   +9 more
openaire   +2 more sources

Assessment of glymphatic function in treatment-resistant depression using DTI-ALPS index

Journal of Affective Disorders
Xin Zhang   +8 more
openaire   +1 more source

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