Results 81 to 90 of about 4,194,149 (156)

Tissue-specific diffusion abnormalities and localized free-water reductions in hypertension despite no detectable group difference in the DTI-ALPS index

Background Essential hypertension (HTN) is an established risk factor for cerebral small vessel disease and cognitive decline.
Jianfeng Chu, Kanlin Lin, Zhifeng Huang, Liyuan Fu, Hui Xiong, Taipeng Zeng, Shangwen Xu, Xiaoyang Wang, Hao Huang, Wenhui Xu   +9 more
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Reduced DTI-ALPS in H-type hypertension: insights into perivascular space function [PDF]

Recent studies suggest that glymphatic dysfunction plays a significant role in vascular cognitive impairment (VCI). Both hypertension and hyperhomocysteinemia are independent risk factors for VCI, and their combination is referred to as H-type ...
Liang Pan, Caihong Song, Chun Zhang, Lingling Sun, Shiying Sheng, Wei Xing   +5 more
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Glymphatic dysfunction links vascular pathology to Alzheimer’s biomarkers and cognitive decline

Alzheimer’s Research & Therapy
Background Vascular damage, including cerebral amyloid angiopathy (CAA) and non-amyloid cerebral small vessel disease (CSVD), has been linked to glymphatic dysfunction, which may contribute to Alzheimer’s disease (AD) pathology and cognitive decline.
Sung Hoon Kang, Seongmi Kim, Young Ju Kim, Heejin Yoo, Eun Hye Lee, Hyemin Jang, Daeun Shin, Jihwan Yun, Jun Pyo Kim, Hee Jin Kim, Duk L. Na, Henrick Zetterberg, Kaj Blennow, Fernando Gonzalez-Ortiz, Nicholas J. Ashton, Theresa A. Day, Marco Duering, Seong-Beom Koh, Sang-Young Kim, Eung Yeop Kim, Sung Tae Kim, Beomseok Sohn, Sang Won Seo   +22 more
doaj   +1 more source

Testing Repeatability of DTI-ALPS in Assessing the Brain Glymphatic System of Neonates with Prenatal Opioid Exposure [PDF]

Background: Prenatal opioid exposure (POE) is a public health concern with risk for neonatal opioid withdrawal syndrome and poor neurodevelopmental outcomes.
Haas, David, Radhakrishnan, Rupa, Puderbaugh, Anna, Vishnubhotla, Ramana, Sadhasivam, Senthilkumar   +4 more
core  

Alterations in the DTI-ALPS index and choroid plexus volume as brain–immune interfacing indicators in neuropsychiatric lupus erythematosus with inflammatory phenotype

Objectives This study aims to compare the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index, choroid plexus (CP) volume and perivascular space (PVS) volume across different subtypes of neuropsychiatric systemic lupus ...
Huanhuan Li, Yueluan Jiang, Yuwei Xia, Hu Liu, Pingting Yang, Zhen Sun, Huiyang Liu, Feng Shi, Bailing Tian, Zhenxing Li, Guoguang Fan   +10 more
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Lateralized glymphatic system impairment in acute ischemic stroke: a DTI–ALPS study of upper limb motor function

Frontiers in Neurology
BackgroundThe glymphatic system (GS) is a brain-specific waste clearance pathway essential for maintaining cerebral homeostasis. Diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) provides a non-invasive means of evaluating GS ...
Zilong Zhu, Zilong Zhu, Zhilong Zhao, Lihua Zhou, Junfeng Xiong, Tianrui Zhang, Chunling Wei, Jianbin Zhang, Jianbin Zhang   +8 more
doaj   +1 more source

G-ALPS : an index for evaluating cognitive decline and aging using diffusion tensor imaging

: INTRODUCTION: The glymphatic system dysfunction is associated with cognitive decline in neurodegenerative diseases such as Alzheimer's disease (AD). METHODS: We introduce the G-Along Perivascular Space (G-ALPS) index, an optimized version of the ALPS ...
Nasab, Elahe Kazemi, Jamali, Ahmadali, Amiri, Mahmood, Van Dam, Debby, Sisara, Majid Abbasi   +4 more
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Exploring glymphatic system alterations in iRBD and Parkinson's disease using automated DTI-ALPS analysis

Diffusion tensor image analysis along the perivascular space (DTI-ALPS) is a potential non-invasive marker of glymphatic function that typically relies on manual region of interest (ROI) placement.
Trnka J., Ružička E., Dušek P., Zogala D., Sonka K., Krupička R., Nepozitek J., Marecek S., Rottova V., Krajča T., Keller J.   +10 more
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Multimodal MRI reveals impaired glymphatic function with choroid plexus enlargement and cerebrospinal fluid expansion in alzheimer’s disease

Scientific Reports
There is increasing evidence that cerebrospinal fluid (CSF) circulation plays a key role in the pathophysiology of Alzheimer’s disease (AD), although the underlying mechanisms remain poorly understood.
Weiqi Lin, Huijuan Chen, Zhanrong Zhang, Yiying Zhang, Xingqun Wang, Yihao Guo, Haodong Qin, Tao Liu, Feng Chen   +8 more
doaj   +1 more source

Disrupted glymphatic function and its relationship with sleep and cognitive impairment in ME/CFS assessed via DTI-ALPS

Frontiers in Neuroscience
The glymphatic system is a recently discovered brain waste clearance system that is mostly active during sleep and disengaged during wakefulness. Impaired glymphatic function leads to the deposition of metabolic waste products in the brain potentially ...
Kiran Thapaliya, Sonya Marshall-Gradisnik, Maira Inderyas, Leighton Barnden   +3 more
doaj   +1 more source