Results 61 to 70 of about 1,324,687 (286)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
String splitting and strong coupling meson decay
, 2005 We study the decay of high spin mesons using the gauge/string theory correspondence. The rate of the process is calculated by studying the splitting of a macroscopic string intersecting a D-brane.
A. L. Cotrone +5 more
core +4 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Research on dual process theory based telecom augmented cognition
Dianxin kexueIncorporating the current works in augmented large language models (LLM), a dual process theory based telecom augmented cognition architecture (TACA) was proposed.This architecture addressed challenges faced by LLM in the field of telecom, such as lack ...
Xiaoxing LIAN +5 more
doaj +2 more sources
Dynamic robust duality in utility maximization
, 2015 A celebrated financial application of convex duality theory gives an explicit relation between the following two quantities: (i) The optimal terminal wealth $X^*(T) : = X_{\varphi^*}(T)$ of the problem to maximize the expected $U$-utility of the ...
Sulem, Agnès, Øksendal, Bernt
core +2 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Performance and Metacognition in Scientific Reasoning: The Covariation Detection Task
Psychological Topics, 2019 The aim of this study was to introduce a modified version of the covariation detection task to the meta-reasoning framework. This task has been used to assess scientific reasoning through the evaluation of fictitious experiment outcomes and hypothesis ...
Pavle Valerjev, Marin Dujmović
doaj +2 more sources
Weak Coupling, Degeneration and Log Calabi-Yau Spaces [PDF]
, 2012 We establish a new weak coupling limit in F-theory. The new limit may be thought of as the process in which a local model bubbles off from the rest of the Calabi-Yau. The construction comes with a small deformation parameter $t$ such that computations in
Donagi, R., Katz, S., Wijnholt, M.
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source