Results 81 to 90 of about 1,324,687 (286)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Thinking Twice about Virtue and Vice: Philosophical Situationism and the Vicious Minds Hypothesis [PDF]
, 2017 This paper provides an empirical defense of credit theories of knowing against Mark Alfano’s challenges to them based on his theses of inferential cognitive situationism and of epistemic situationism.
Axtell, Guy
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A dual process theory of optimistic cognition
, 2014 Optimism is a prevalent bias in human cognition including variations like self-serving beliefs, illusions of control and overly positive views of one's own future. Further, optimism has been linked with both success and happiness.
Hutter, Marcus, Sunehag, Peter
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
East European Journal of Psycholinguistics, 2017 The title of this study is inspired by Daniel Kahneman’s best-selling book Thinking, Fast and Slow. In it, the Nobel Prize winner explains in great detail the working of two systems of human reasoning: System 1, which is fast, automatic, associative ...
Vasyl Starko
doaj +1 more source
Linking pattern to process in cultural evolution: explaining material culture diversity among the Northern Khanty of Northwest Siberia [PDF]
, 2009 Book description: This volume offers an integrative approach to the application of evolutionary theory in studies of cultural transmission and social evolution and reveals the enormous range of ways in which Darwinian ideas can lead to productive ...
Jordan, P.
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D3-D7 Holographic dual of a perturbed 3D CFT
, 2013 An appropriately oriented D3-D7-brane system is the holographic dual of relativistic Fermions occupying a 2+1-dimensional defect embedded in 3+1-dimensional spacetime.
E. Witten +4 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Frontiers in Psychology, 2014 In several reported previously studies, participants increased their normative correctness after being instructed to think hypothetically, specifically taking the perspective of an expert or researcher (Beatty & Thompson 2012, Morsanyi & Handley 2012 ...
Michal eBialek, Przemysław eSawicki
doaj +1 more source