Results 81 to 90 of about 15,990,582 (283)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Reviewing the Dual-Process Theory of Moral Judgment
, 2015 The dual-process theory of moral judgment by Joshua Greene has influenced much of contemporary research on moral cognition. The dual-process research paradigm can be argued to have yielded fruitful results.
Niklas, Stenberg
core +2 more sources
Multimodal perceptual curation for cognitive autonomy in Generation Z decision making
Frontiers in PsychologyRecommendation algorithms increasingly shape the perceptual environments through which young users encounter information, evaluate options, and form preferences.
Zhean Zhu, Kai Wang
doaj +1 more source
A Test of Dual Labor Market Theory [PDF]
Despite substantial differences in their views of the appropriate policy response to the existence of poverty, neither the proponents of dual market theory nor its critics have proposed potentially conclusive tests of the dual market hypothesis.This ...
William T. Dickens, Kevin Lang
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Behavioral SciencesEthical decision-making in professional contexts requires integrating behavioral performance and neural processes, as it involves both deliberative and intuitive mechanisms. However, empirical evidence integrating these levels of analysis in professional
Jorge Vergara-Morales +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The dual-process theory of moral judgment does not deny that people can make compromise judgments. [PDF]
Proc Natl Acad Sci U S A, 2023 Greene JD.
europepmc +1 more source