Results 101 to 110 of about 687,252 (300)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Reviewing the Dual-Process Theory of Moral Judgment
, 2015 The dual-process theory of moral judgment by Joshua Greene has influenced much of contemporary research on moral cognition. The dual-process research paradigm can be argued to have yielded fruitful results.
Niklas, Stenberg
core
Performance and Metacognition in Scientific Reasoning: The Covariation Detection Task
Psychological Topics, 2019 The aim of this study was to introduce a modified version of the covariation detection task to the meta-reasoning framework. This task has been used to assess scientific reasoning through the evaluation of fictitious experiment outcomes and hypothesis ...
Pavle Valerjev, Marin Dujmović
doaj +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Testing Dual Labor Market Theory: A Reconsideration of the Evidence [PDF]
This paper replicates and extends our earlier analysis of dual market theory. We use a technique which estimates for each worker a probability of being in the primary sector on the basis of his characteristics.
William T. Dickens, Kevin Lang
core
Frontiers in Human NeuroscienceIntroductionThe Model Human Processor (MHP), while useful, lacks direct neurophysiological validation. This study aimed to validate and extend the MHP by analyzing P300 and Bereitschaftspotential (BP) brainwave components.MethodsOur initial finding of ...
Toshitaka Higashino, Naoki Wakamiya
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Dual process theory of moral judgment
, 2017 The philosopher and psychologist Joshua Greene came up with a theory of moral judgement that integrates both rationalism and intuitionism - the dual process theory.
Schinková, Kristýna
core
Synergizing Retrieval and CoT Reasoning via Spatial Consensus for Worldwide Visual Geo-Localization
ISPRS International Journal of Geo-InformationWorldwide visual geo-localization aims to predict the geographic coordinates of an image capture location from visual content alone, posing unique challenges due to the vast scale of the Earth’s surface and pervasive visual ambiguity across distant ...
Yong Tang +4 more
doaj +1 more source