Results 111 to 120 of about 15,990,582 (283)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

The Impact of Generative AI on Marketing Communication:

open access: yesMaketingu Janaru
This study investigates how generative AI is transforming marketing communication (MarCom) and altering the power dynamics among brand companies, platform providers, and consumers. Drawing on Porter and Millar’s (1985) and Porter’s (2001) frameworks, the
Naohiko Oikawa, Keisuke Kamata
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Psychological assessment in forensic settings: new methodological conceptions and ethical considerations

open access: yesFrontiers in Psychology
Forensic psychological and psychiatric evaluations—understood here as assessments addressing legally operative questions such as, for instance, competency to stand trial, criminal responsibility (sanity), violence risk, but also those on legal capacity ...
Alfredo Verde, Emanuela Saveria Gritti
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

From gatekeeper to architect: operationalizing AI as a cognitive partner in higher education

open access: yesFrontiers in Education
In higher education, debates about Generative Artificial Intelligence (GenAI) often polarize around academic integrity risks and efficiency gains. A growing body of post-2023 work has begun to move beyond this dichotomy, proposing constrained tutoring ...
Carlos Ugrinowitsch   +1 more
doaj   +1 more source

Pragmatism, Dual‐Process Theory, and the Study of Reflective Cognition

open access: yes
This article advances dual‐process theory (DPT) by developing a pragmatist framework for the study of reflective cognition. Although dual‐process models were introduced to sociology via Bourdieusian practice theory, Bourdieusian DPT has proven inadequate
Gordon Brett
core   +1 more source

An examination of attentional control theory, perceptual anticipation and dual task paradigms [PDF]

open access: yes, 2018
Skilled perceptual anticipation, the capability of anticipating the actions of others and processing information under severe time- and task-constraints, is a critical component in many dynamic real-world activities and cognitive tasks, particularly in ...
Mitchell, D.
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

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