Results 111 to 120 of about 687,252 (300)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Some memories are odder than others : Judgments of episodic oddity violate known decision rules

, 2011
Current decision models of recognition memory are based almost entirely on one paradigm, single item old/new judgments accompanied by confidence ratings.
Ian G. Dobbins, Dobbins, Ian, Emily N. Guhl, O'Connor, Akira Robert, Akira R. O’Connor, Justin C. Cox, Cox, Justin, Guhl, Emily   +7 more
core   +1 more source

Algorithmic Insights into Human Irrationality: Machine Learning Approaches to Detecting Cognitive Biases and Motivated Reasoning

Machine Learning and Knowledge Extraction
This study illuminates fundamental questions in behavioral science through advanced machine learning methodologies applied to large-scale public opinion data.
Sarthak Pattnaik, Chhayank Jain, Eugene Pinsky   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Dual Labor Market and Endogenous Fluctuations [PDF]

We study the influence of wage differential on the emergence of endogenous fluctuations. In this way, we introduce a dual labor market, based on the Shapiro-Stiglitz efficiency wage theory in an overlapping generations model. We show that wage inequality
Thomas Seegmuller, Francesco De Palma
core  

Untangling the Mystery of Intuitive-Analytic Interactions in Crisis Response Operations: A Dual-Process Perspective

Whilst it is often claimed that experienced crisis responders are likely to adopt the intuitive and analytical thinking styles when solving complex problems in time-pressured crisis situations, scholarly efforts to explicate the nature of interactions ...
Ogwu, I. J., Okoli, J.
core   +1 more source

Extending AdS/CFT: dual states for new geometries [PDF]

, 2006
In this thesis we present research that extends our knowledge of the AdS/CFT correspondence; in particular we look at various non-supersymmetric Spacetimes and their conjectured dual field theory states.
Titchener, Georgina
core  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source