Results 91 to 100 of about 687,252 (300)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Frontiers in PsychologyForensic psychological and psychiatric evaluations—understood here as assessments addressing legally operative questions such as, for instance, competency to stand trial, criminal responsibility (sanity), violence risk, but also those on legal capacity ...
Alfredo Verde, Emanuela Saveria Gritti
doaj +1 more source
Frontiers in Psychology, 2014 In several reported previously studies, participants increased their normative correctness after being instructed to think hypothetically, specifically taking the perspective of an expert or researcher (Beatty & Thompson 2012, Morsanyi & Handley 2012 ...
Michal eBialek, Przemysław eSawicki
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
tDCS Over DLPFC Leads to Less Utilitarian Response in Moral-Personal Judgment
Frontiers in Neuroscience, 2018 The profound nature of moral judgment has been discussed and debated for centuries. When facing the trade-off between pursuing moral rights and seeking better consequences, most people make different moral choices between two kinds of dilemmas.
Haoli Zheng +6 more
doaj +1 more source
Choice experiment selection of tourism destinations in a dual process theory framework: The role of decision style and potential to promote deliberation. [PDF]
PLoS One, 2022 Lindberg K, Stemmer K.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The birth of string theory: Introduction and synopsis [PDF]
, 2012 This is a draft of the introduction to the collective volume "The birth of string theory" (CUP, 2012), including the book's index and preface. The book explores the history of the theory’s early stages of development, as told by its main protagonists. It
Cappelli, Andrea +3 more
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