Results 261 to 270 of about 134,984 (294)
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Dual specificity phosphatases in prostate cancer
Molecular and Cellular Endocrinology, 2009The mitogen-activated protein kinase (MAPK) pathways have critical roles in growth, differentiation, and cell death. Their activity is regulated by an intricate network of crosstalk with other signaling pathways, as well as more directly by two subgroups of the dual specificity phosphatases (DUSPs), the MAPK phosphatases (MKPs) and atypical DUSPs ...
Yke Jildouw, Arnoldussen +1 more
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Dual Specificity Phosphatases Support Axon Plasticity and Viability
Molecular Neurobiology, 2020In peripheral neuropathies, axonal degeneration (AxD) impairs the prognosis for recovery. Here, we describe a role for dual specificity phosphatases (DUSPs; MAP kinase phosphatases, MKPs), in supporting autonomous axon plasticity and viability. Both DUSPs 1 and 4 were identified within intact or axotomized sensory neurons.
Ambika Chandrasekhar +4 more
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Dual specific phosphatases (DUSPs) in cardiac hypertrophy and failure
Cellular Signalling, 2021Pressure overload and other stress stimuli elicit a host of adaptive and maladaptive signaling cascades that eventually lead to cardiac hypertrophy and heart failure. Among those, the mitogen-activated protein kinase (MAPK) signaling pathway has been shown to play a prominent role.
Michael, Mutlak, Izhak, Kehat
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Immunomodulation of dual specificity phosphatase 4 during visceral leishmaniasis
Microbes and Infection, 2018DUSP4, an inducible protein has a substrate specificity toward ERK1/2, a component of MAP kinase which is enhanced during Leishmania infection. The DUSP4-/- mice show increased susceptibility towards the infection caused by Toxoplasma gondii and Leishmania mexicana.
Shabina, Parveen +5 more
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Dual-specificity MAP kinase phosphatases (MKPs) and cancer
Cancer and Metastasis Reviews, 2008There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells and these can be subdivided into three groups. The first comprises DUSP1/MKP-1, DUSP2/PAC1, DUSP4/MKP-2 and DUSP5/hVH-3, which are inducible nuclear phosphatases. With the exception of DUSP5, these MKPs display a
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Dual Specificity Phosphatase 5‐Substrate Interaction: A Mechanistic Perspective
Comprehensive Physiology, 2017ABSTRACTThe mammalian genome contains approximately 200 phosphatases that are responsible for catalytically removing phosphate groups from proteins. In this review, we discuss dual specificity phosphatase 5 (DUSP5). DUSP5 belongs to the dual specificity phosphatase (DUSP) family, so named after the family members’ abilities to remove phosphate groups ...
Kutty, Raman G. +7 more
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Functional Analysis of Dual-Specificity Protein Phosphatases in Angiogenesis
2016Therapeutic perspectives targeting angiogenesis in cancer stimulated an intense investigation of the mechanisms triggering and governing angiogenic processes. Several publications have highlighted the importance of typical dual-specificity phosphatases (DSPs) or MKPs in endothelial cells and their role in controlling different biological functions ...
Amand, Mathieu +4 more
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