Results 51 to 60 of about 134,984 (294)

Dual-specificity phosphatase (DUSP6) in human glioblastoma: epithelial-to-mesenchymal transition (EMT) involvement

BMC Research Notes, 2020
Objective Glioblastoma (GBM) is the most aggressive and common form of primary brain cancer. Survival is poor and improved treatment options are urgently needed.
Candida Zuchegna, Erika Di Zazzo, Bruno Moncharmont, Samantha Messina   +3 more
doaj   +1 more source

Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. [PDF]

, 2019
BACKGROUND:The Human Epidermal Growth Factor Receptor (EGFR/HER1) can be activated by several ligands including Transforming Growth Factor alpha (TGF-α) and Epidermal Growth Factor (EGF).
Dutta, Pranabananda, Farias-Eisner, Robin, Nava, Miguel, Vadgama, Jaydutt V, Wu, Yanyuan, Zemke, Nathan R   +5 more
core   +5 more sources

Role of Dual-Specificity Phosphatase 1 in Glucocorticoid-Driven Anti-inflammatory Responses

Frontiers in Immunology, 2019
Glucocorticoids (GCs) potently inhibit pro-inflammatory responses and are widely used for the treatment of inflammatory diseases, such as allergies, autoimmune disorders, and asthma. Dual-specificity phosphatase 1 (DUSP1), also known as mitogen-activated
Jessica Hoppstädter, Alaina J. Ammit, Alaina J. Ammit   +2 more
doaj   +1 more source

Phosphorylation of nuclear Tau is modulated by distinct cellular pathways [PDF]

, 2018
Post-translational protein modification controls the function of Tau as a scaffold protein linking a variety of molecular partners. This is most studied in the context of microtubules, where Tau regulates their stability as well as the distribution of ...
Boersema, Paul, Cal\uec, Tito, Foglieni, Chiara, Paganetti, Paolo, Papin, St\ue9phanie, Picotti, Paola, Salvad\ue8, Agnese, Sola, Martina, Ulrich, Giorgio   +8 more
core   +2 more sources

Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6. [PDF]

, 2014
BackgroundConventional p38α inhibitors have limited efficacy in rheumatoid arthritis, possibly because p38 blockade suppresses the counter-regulatory mechanisms that limit inflammation.
Boyle, David L, Firestein, Gary S, Hammaker, Deepa, Topolewski, Katharyn   +3 more
core   +3 more sources

DUSP10 (dual specificity phosphatase 10) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on DUSP10 (dual specificity phosphatase 10), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +2 more sources

The First Green Lineage cdc25 Dual-Specificity Phosphatase [PDF]

Cell Cycle, 2004
The Cdc25 protein phosphatase is a key enzyme involved in the regulation of the G(2)/M transition in metazoans and yeast. However, no Cdc25 ortholog has so far been identified in plants, although functional studies have shown that an activating dephosphorylation of the CDK-cyclin complex regulates the G(2)/M transition.
Khadaroo, B., Robbens, S., Ferraz, C., Derelle, E., Eychenié, S., Cooke, R., Peaucellier, G., Delseny, M., Demaille, J., Peer, Y. van De, Picard, A., Moreau, H.   +11 more
openaire   +2 more sources

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase [PDF]

, 1997
Protein tyrosine phosphatases (PTPs) have long been thought to play a role in tumor suppression due to their ability to antagonize the growth promoting protein tyrosine kinases.
Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R., Tonks, N. K.   +7 more
core   +1 more source

Dual-specificity phosphatase 14 inhibits the growth of cervical cancer cells by regulating the transforming growth factor-beta-activated kinase 1 and NOD-like receptor pyrin domain containing 3 inflammatory pathways

Journal of International Medical Research
Objective This study investigated the role and mechanism of dual-specificity phosphatase 14 in cervical cancer. Methods In this experimental study, clinical samples from five patients with cervical squamous cell carcinoma and five with chronic cervicitis
Yuanyuan Zhang, Qian Zhuo, Shaliya Abuduwufu, Aerziguli Wushouer   +3 more
doaj   +1 more source

Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. [PDF]

, 2012
Cells rely on the coordinated regulation of lipid phosphoinositides and Rab GTPases to define membrane compartment fates along distinct trafficking routes.
Cox, Sarah, Jean, Steve, Kiger, Amy, Robinson, Fred L, Schmidt, Eric J   +4 more
core   +1 more source