Results 61 to 70 of about 24,582 (307)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dual Boundary Element Method for fatigue crack growth: implementation of the Richard’s criterion [PDF]

, 2013
A new criterion for fatigue crack growth, whose accuracy was previously tested in the literature with the Finite Element Method, is here adopted with a Dual Boundary Element formulation.
BENEDETTI, Ivano, Aliabadi, MH, Bonanno, F, MILAZZO, Alberto   +3 more
core  

Estimation of Stress Intensity Factor by Using a New Fast Multipole Dual-Boundary Element Method

Mathematics
Cracks and defects are inevitable during the long-term use of structures. This study focuses on determining the stress intensity factors of multi-cracked structures by using a new fast multipole dual boundary element method.
Cong Li, Yan Meng, Bin Hu, Zhongrong Niu
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analytical model of a dual‐stator spoke‐type permanent magnet synchronous machines accounting for tooth‐tips

IET Electric Power Applications, 2022
This paper presents an analytical model of a dual‐stator spoke‐type permanent magnet (DSSTPM) synchronous machines accounting for tooth‐tips. Based on the two‐dimensional (2‐D) subdomain technique, the field domain of DSSTPM machine is divided into seven
Minchen Zhu, Pingliang Zeng, Xiansi Lou, Guijiang Mao, Yongliang Dou, Zhen He   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

High-order space-time finite element schemes for acoustic and viscodynamic wave equations with temporal decoupling [PDF]

, 2014
Copyright @ 2014 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.We revisit a method ...
Mark P Brewin, Shuhua Hu, Simon Shaw, Carola Kruse, Birch, MJ, Zackary R Kenz, Kruse, C, Brewin, MP, John R Whiteman, Maischak, M, Banks, HT, Malcolm J Birch, H. T. Banks, Stephen E Greenwald, Greenwald, SE, Kenz, ZR, Matthias Maischak, Whiteman, JR, Hu, S, Shaw, S   +19 more
core   +1 more source

Trefftz- type FEM for solving orthotropic potential problems

Latin American Journal of Solids and Structures
A simple Trefftz-type finite element method (TFEM) is proposed for solving certain potential problems in orthotropic media. The "body force", which is induced by internal sources or sinks, may produce domain integrals in the standard Trefftz finite ...
K.Y. Wang, P.C. Li, D.Z. Wang
doaj   +1 more source

Boundary element analysis of rotating functionally graded anisotropic fiber-reinforced magneto-thermoelastic composites

Open Engineering, 2022
The primary goal of this article is to implement a dual reciprocity boundary element method (DRBEM) to analyze problems of rotating functionally graded anisotropic fiber-reinforced magneto-thermoelastic composites. To solve the governing equations in the
Fahmy Mohamed Abdelsabour, Almehmadi Mohammed M.   +1 more
doaj   +1 more source

A direct evaluation of stress intensity factors using the Extended Dual Boundary Element Method [PDF]

Engineering Analysis with Boundary Elements, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
I.A. Alatawi, J. Trevelyan
openaire   +2 more sources