Results 61 to 70 of about 337,484 (235)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Adaptive smoothed FEM for forming simulations [PDF]
, 2012 FEMsimulation of large deformations as occur in metal forming processes is usually accompanied with highly distorted meshes. This leads first to a reduction of accuracy and later to loss of convergence when implicit solvers are used.
Boogaard, A.H. van den, Quak, W.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 2017 The present paper deals with the numerical solution of the incompressible Navier-Stokes equations using high-order discontinuous Galerkin (DG) methods for discretization in space.
Fehn, Niklas +2 more
core +1 more source
The dual reciprocity boundary element method for magnetohydrodynamic channel flows
The ANZIAM Journal, 2002 In this paper, we consider the problem of the steady-state fully developed magnetohydrodynamic (MHD) flow of a conducting fluid through a channel with arbitrary wall conductivity in the presence of a transverse external magnetic field with various inclined angles.
Zhu, Song-Ping, Liu, Huan-Wen
openaire +3 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Estimation of Stress Intensity Factor by Using a New Fast Multipole Dual-Boundary Element Method
MathematicsCracks and defects are inevitable during the long-term use of structures. This study focuses on determining the stress intensity factors of multi-cracked structures by using a new fast multipole dual boundary element method.
Cong Li, Yan Meng, Bin Hu, Zhongrong Niu
doaj +1 more source
Variational Data Assimilation of Tides
Journal of Marine Science and Engineering, 2020 This paper presents an incremental variational method to assimilate the observed tidal harmonic constants using a frequency domain linearized shallow water equation.
Lei Shi, Liujuan Tang, Edward Myers
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IET Electric Power Applications, 2022 This paper presents an analytical model of a dual‐stator spoke‐type permanent magnet (DSSTPM) synchronous machines accounting for tooth‐tips. Based on the two‐dimensional (2‐D) subdomain technique, the field domain of DSSTPM machine is divided into seven
Minchen Zhu +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source