Results 81 to 90 of about 337,484 (235)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

hp-Version discontinuous Galerkin methods with interior penalty for partial differential equations with nonnegative characteristic form. [PDF]

, 2002
In this paper we consider the a posteriori and a priori analysis of hp-discontinuous Galerkin interior penalty methods for second-order partial differential equations with nonnegative characteristic form. In particular, we discuss the question of error
Harriman, Kathryn, Houston, P., Senior, Bill, Suli, Endre   +3 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Software frameworks for integral equations in electromagnetic scattering based on Calder\'on identities

, 2017
In recent years there have been tremendous advances in the theoretical understanding of boundary integral equations for Maxwell problems. In particular, stable dual pairing of discretisation spaces have been developed that allow robust formulations of ...
Betcke, Timo, Burman, Erik, Scroggs, Matthew, Wout, Elwin van 't, Śmigaj, Wojciech   +4 more
core   +1 more source

Effect of Torso Non-Homogeneities in the quasi-static inverse problems arising in electrocardiology

Moroccan Journal of Pure and Applied Analysis, 2019
In the present paper, an homogeneous and non-homogeneous inverse problem constrained by the stationary problem in electrocardiology representing the heart, lungs surfaces, and torso model is investigated.
Ainseba BedrEddine, Bendahmane Mostafa, Lopez Alejandro   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

An Analysis of Water Infiltration in Furrow Irrigation Channels with Plants in Various Types of Soil in the Special Region of Yogyakarta Using Dual Reciprocity Boundary Element Method

JTAM (Jurnal Teori dan Aplikasi Matematika)
The analysis of water infiltration channels requires significant time and cost when conducted through laboratory experiments. Alternatively, mathematical modeling followed by numerical method can be employed.
Yanne Irene, Muhammad Manaqib, Vina Wulandari Ramadhanty, Asri Ria Affriani   +3 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

About least-squares type approach to address direct and controllability problems [PDF]

, 2015
- We discuss the approximation of distributed null controls for partial differential equations. The main purpose is to determine an approximation of controls that drives the solution from a prescribed initial state at the initial time to the zero target ...
Münch, Arnaud, Pedregal, Pablo
core   +2 more sources