Results 71 to 80 of about 24,582 (307)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A modified dual-level fast multipole boundary element method for large-scale three-dimensional potential problems

, 2022
A modified dual-level fast multipole boundary element method is proposed in this article. The core idea of the method is to use a dual-level structure to handle the excessive storage requirement and ill-conditioned problems resulting from the fully ...
Li, Junpu, Chen, Wen, Qin, Qinghua, Fu, Zhuojia   +3 more
core   +1 more source

DUAL RECIPROCITY BOUNDARY ELEMENT METHOD FOR SOLVING TIME-DEPENDENT WATER INFILTRATION PROBLEMS IN IMPERMEABLE CHANNEL IRRIGATION SYSTEMS

Barekeng
The mathematical model of water infiltration in a furrow irrigation channel with an impermeable layer in homogeneous soil is formulated as a Boundary Value Problem (BVP) with the Modified Helmholtz Equation as the governing equation and mixed boundary ...
Yanne Irene, Muhammad Manaqib, Mochammad Rafli Alamsyah, Madona Yunita Wijaya   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Efficient numerical methods to approach solutions of quasi-static contact problems

Results in Applied Mathematics
In this paper, a new boundary element method and generalized Newton method for the resolution of quasi-static contact problems with friction in 2D is presented.
Lionel Ouya Ndjansi, Laurent Tchoualag, Jean Louis Woukeng   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Stokes–Brinkman formulation for prediction of void formation in dual-scale fibrous reinforcements: a BEM/DR-BEM simulation [PDF]

A numerical study of voids formation in dual-scale fibrous reinforcements is presented. Flow fields in channels (Stokes) and tows (Brinkman) are solved via direct Boundary Element Method and Dual Reciprocity Boundary Element Method, respectively.
Power, H., Londo�o, C?sar Nieto, Pati�o, Iv�n David, Fl?rez, Whady Felipe   +3 more
core   +1 more source

Dynamic fracture analysis of Kane–Mindlin plates using the dual boundary element method [PDF]

, 2019
In this paper, a new dual boundary element formulation is presented for dynamic crack problems in finite-thickness plates under in-plane loadings. The proposed formulation is based on a first-order plate theory (Kane–Mindlin theory) taking into account a
Li, Jun, Aliabadi, MH, Khodaei, Zahra Sharif   +2 more
core   +1 more source

Nonlinear boundary element method and its applications: a review

Cogent Engineering
The Boundary Element Method (BEM) has long been recognized as an efficient numerical technique for the solution of linear boundary value problems, particularly those involving unbounded domains, free-surface effects and radiation conditions. However, its
Kirana Kumara P
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source