Results 81 to 90 of about 662,452 (292)

Gait and cognition: mapping the global and discrete relationships in ageing and neurodegenerative disease [PDF]

, 2016
Recent research highlights the association of gait and cognition in older adults but a stronger understanding is needed to discern coincident pathophysiology, patterns of change, examine underlying mechanisms and aid diagnosis.
Bunce, Jennifer, Burn, David, Lord, Sue, Morris, Rosie, Rochester, Lynn   +4 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dual tasking in Parkinson's disease: cognitive consequences while walking [PDF]

, 2017
Published in final edited form as: Neuropsychology. 2017 September; 31(6): 613–623. doi:10.1037/neu0000331.OBJECTIVE: Cognitive deficits are common in Parkinson's disease (PD) and exacerbate the functional limitations imposed by PD's hallmark motor ...
Barthelemy, Olivier J., Cronin-Golomb, Alice, Ellis, Terry D., Neargarder, Sandy, Ren, Xiaolin, Salazar, Robert D., Toraif, Noor   +6 more
core   +1 more source

A disorder parameter for dual superconductivity in gauge theories [PDF]

Nuclear Physics B - Proceedings Supplements, 1998
Dual superconductivity in the confining phase of gauge theories is discussed in terms of a disorder parameter which vanishes in normal phase and is different from zero in the superconducting phase.
Di Giacomo A, Lucini B, Montesi L, PAFFUTI, GIAMPIERO   +3 more
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Mutual Composite Fermion and composite Boson approaches to balanced and imbalanced bilayer quantum Hall system: an electronic analogy of the Helium 4 system

, 2007
We use both Mutual Composite Fermion (MCF) and Composite Boson (CB) approach to study balanced and im-balanced Bi-Layer Quantum Hall systems (BLQH) and make critical comparisons between the two approaches.
Affleck, Affleck, Anderson, Andreev, Apalkov, Balents, Brazovskii, Brey, Chaikin, Chen, Chester, Cote, Crowell, Dasgupta, Diamantini, Eisenstein, Fertig, Girvin, Girvin, Halperin, Halperin, Hanna, He, Jain, Jiang, Jinwu Ye, Joglekar, Joglekar, Kapitza, Kellogg, Kellogg, Kim, Kim, Laughlin, Lopez, López, López, Manoharan, Moon, Murthy, Narasimhan, Osheroff, Peskin, Pisarski, Raikh, Read, Rossi, Sachdev, Sakhi, Sang Jeon, Scarola, Schliemann, Senthil, Simon, Spielman, Spielman, Stern, Ussishkin, Veillette, Wang, Wang, Wen, Wen, Wen, Wiechert, Yang, Yang, Yang, Ye, Ye, Ye, Ye, Ye, Ye, Ye, Ye, Ye, Zhang, Zhang, Zheng   +79 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Detecting Cognitive Load during Working Memory Tasks utilizing a Digitizer Tablet [PDF]

, 2017
The purpose of this line of research is to determine whether the ‘Digitizer’ is a reliable and valid way to measure cognitive load during dual working memory-drawing tasks.
Srivastava, Pradyumn, Ward, Cassandra K
core   +2 more sources

Men and women from the STRIDE clinical trial: An assessment of stimulant abstinence symptom severity at residential treatment entry [PDF]

, 2015
Background and Objectives Gender‐specific factors associated with stimulant abstinence severity were examined in a stimulant abusing or dependent residential treatment sample (N = 302).
Burrow, Allison, Carmody, Thomas, Chartier, Karen G., Greer, Tracy L., Killeen, Therese K., Sanchez, Katherine, Trivedi, Madhukar H.   +6 more
core   +2 more sources