Results 251 to 260 of about 133,554 (285)

Dual specificity phosphatase-1 (DUSP-1) - A novel mediator of the anti-inflammatory effects of glucocorticoids?

, 2016
Abraham, S, Lawrence, T, Saklatvala, J, Clark, A   +3 more
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A dual-specificity phosphatase, MAP kinase phosphatase 1, positively regulates blue light-mediated seedling development in Arabidopsis

Planta, 2021
A dual-specificity phosphatase MKP1 negatively regulates the activity of MPK6 by dephosphorylating it and acts as a positive regulator of blue light (BL)-mediated photomorphogenic development in Arabidopsis. Reversible phosphorylation of proteins is one of the major post-translational modifications in nearly all signaling pathways in plants. MAP kinase
Deepanjali Verma, Prakash Kumar Bhagat, Alok Krishna Sinha   +2 more
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Dual-specificity phosphatase 1: a critical regulator of innate immune responses

Biochemical Society Transactions, 2006
Innate immune responses are critically dependent on MAPK (mitogen-activated protein kinase) signalling pathways, in particular JNK (c-Jun N-terminal kinase) and p38 MAPK. Both of these kinases are negatively regulated via their dephosphorylation by DUSP1 (dual­-specificity phosphatase 1).
S M, Abraham, A R, Clark
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Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase‐1, at 1.5 Å resolution

Proteins: Structure, Function, and Bioinformatics, 2006
AbstractHuman JNK stimulatory phosphatase‐1 (JSP‐1) is a novel member of dual specificity phosphatases. A C‐terminus truncated JSP‐1 was expressed in Escherichia coli and was crystallized using the sitting‐drop vapor diffusion method. Thin‐plate crystals obtained at 278 K belong to a monoclinic space group, C2, with unit‐cell parameters a = 84.0 Å, b =
Takehiro, Yokota, Yukinori, Nara, Akiko, Kashima, Keiko, Matsubara, Satoru, Misawa, Ryohei, Kato, Shigetoshi, Sugio   +6 more
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Dual-specificity phosphatase 18 modulates the SUMOylation and aggregation of Ataxin-1

Biochemical and Biophysical Research Communications, 2018
We previously reported that SUMOylation promotes the aggregation of ataxin-1 and JNK is involved in the process. Here we show that dual-specificity phosphatase 18 (DUSP18), a member of protein tyrosine phosphatases, exerts the opposite effects on ataxin-1. DUSP18 associated with ataxin-1 and suppressed JNK activated by ataxin-1.
Joohyun, Ryu, Do Hee, Lee
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The PAC-1 dual specificity phosphatase predicts poor outcome in serous ovarian carcinoma

Gynecologic Oncology, 2004
Data regarding signal transduction pathways in human tumors are largely confined to cell line studies to date. We have recently reported on the activation and prognostic role of mitogen-activated protein kinases (MAPK) in ovarian carcinoma in effusions.
Vered, Givant-Horwitz, Ben, Davidson, Jeanne Mette, Goderstad, Jahn M, Nesland, Claes G, Tropé, Reuven, Reich   +5 more
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Positive regulation of apoptosis signal-regulating kinase 1 by dual-specificity phosphatase 13A

Cellular and Molecular Life Sciences, 2010
Apoptosis signal-regulating kinase 1 (ASK1), a member of the MAP kinase kinase kinase, is activated by several death stimuli and is tightly regulated by several mechanisms such as interactions with regulatory proteins and post-translational modifications.
Jae Eun, Park, Byoung Chul, Park, Hyun-A, Kim, Mina, Song, Sung Goo, Park, Do Hee, Lee, Hyeoung-Joon, Kim, Hyung-Kyoon, Choi, Jong-Tae, Kim, Sayeon, Cho   +9 more
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NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26)

Biochemical and Biophysical Research Communications, 2009
Protein phosphorylation plays critical roles in many regulatory mechanisms controlling cell activities and thus involved in various diseases. The cellular equilibrium of phosphorylation is regulated through the actions of protein kinases and phosphatases. Therefore, these regulatory proteins have emerged as promising targets for drug development.
Mina, Song, Jae Eun, Park, Sung Goo, Park, Do Hee, Lee, Hyung-Kyoon, Choi, Byoung Chul, Park, Seong Eon, Ryu, Jae Hoon, Kim, Sayeon, Cho   +8 more
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Down-regulation of the dual-specificity phosphatase MKP-1 suppresses tumorigenicity of pancreatic cancer cells

Gastroenterology, 2003
In both pancreatic cancer and chronic pancreatitis, there is enhanced expression of mitogenic growth factors and their tyrosine kinase receptors, which have the capacity to activate mitogen-activated protein kinase (MAPK). In view of the important role of MAPK kinase phosphatase (MKP)-1 in the regulation of MAPK activation, the expression and ...
Quan, Liao, Junchao, Guo, Jörg, Kleeff, Arthur, Zimmermann, Markus W, Büchler, Murray, Korc, Helmut, Friess   +6 more
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