Results 261 to 270 of about 133,554 (285)
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Experimental Cell Research, 2005
Hypoxia-inducible factor 1 (HIF-1) plays a critical role in controlling oxygen delivery and metabolic adaptation to hypoxic conditions in hypoxic tumor cells. HIF-1 activation is initiated by several factors including mitogen-activated protein kinase (MAPK) superfamily. We have previously reported that mitogen-activated protein kinase phosphatase DUSP1
Changjiang, Liu +8 more
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Hypoxia-inducible factor 1 (HIF-1) plays a critical role in controlling oxygen delivery and metabolic adaptation to hypoxic conditions in hypoxic tumor cells. HIF-1 activation is initiated by several factors including mitogen-activated protein kinase (MAPK) superfamily. We have previously reported that mitogen-activated protein kinase phosphatase DUSP1
Changjiang, Liu +8 more
openaire +2 more sources
Biochemical and Biophysical Research Communications, 2003
Hypoxia-inducible factor 1 (HIF-1) is a phosphorylated protein and its phosphorylation is involved in HIF-1alpha subunit stabilization as well as in the regulation of HIF-1 transcriptional activity. In a variety of cell lines, the phosphorylation of HIF-1alpha is dependent on ERK or p38, two members of the mitogen-activated protein kinase (MAPK ...
Changjiang, Liu +9 more
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Hypoxia-inducible factor 1 (HIF-1) is a phosphorylated protein and its phosphorylation is involved in HIF-1alpha subunit stabilization as well as in the regulation of HIF-1 transcriptional activity. In a variety of cell lines, the phosphorylation of HIF-1alpha is dependent on ERK or p38, two members of the mitogen-activated protein kinase (MAPK ...
Changjiang, Liu +9 more
openaire +2 more sources
Fish & Shellfish Immunology
The dual-specificity phosphatase (DUSP) family plays key roles in the maintenance of cellular homeostasis and apoptosis etc. In this study, the DUSP member DUSP1 of Epinephelus coioides was characterized: the length was 2371 bp including 281 bp 5' UTR, 911 bp 3' UTR, and a 1125 bp open reading frame encoding 374 amino acids. E.
Jia-Yang, He +9 more
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The dual-specificity phosphatase (DUSP) family plays key roles in the maintenance of cellular homeostasis and apoptosis etc. In this study, the DUSP member DUSP1 of Epinephelus coioides was characterized: the length was 2371 bp including 281 bp 5' UTR, 911 bp 3' UTR, and a 1125 bp open reading frame encoding 374 amino acids. E.
Jia-Yang, He +9 more
openaire +2 more sources
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2022
Objective To investigate the effect of dual-specificity phosphatase 1/optical atrophy 1 (DUSP1/OPA1) signaling pathway on vascular smooth muscle cell (VSMC) calcification.Methods An in vitro model of VSMC calcification was induced by exposure to β-glycerophosphate and calcium chloride.VSMC calcification was assessed by Alizarin Red S staining and ...
Wei-Ren, Chen +7 more
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Objective To investigate the effect of dual-specificity phosphatase 1/optical atrophy 1 (DUSP1/OPA1) signaling pathway on vascular smooth muscle cell (VSMC) calcification.Methods An in vitro model of VSMC calcification was induced by exposure to β-glycerophosphate and calcium chloride.VSMC calcification was assessed by Alizarin Red S staining and ...
Wei-Ren, Chen +7 more
openaire +1 more source
Dual-specificity protein phosphatase-1 positively regulates the anti-mycobacterial responses
2011Tuberculosis is still prevalent around world. It is caused by Mycobacterium tuberculosis (Mtb). This microbe stimulates monocytes/macrophages leading to the production of specific cytokines for initiating immune responses. Of these cytokines, tumour necrosis factor-alpha (TNF-α) is crucial for inducing the granuloma formation for restricting Mtb ...
Yim, HCH, Li, JCB, Lau, ASY
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The expression of dual-specificity phosphatase 1 mRNA is downregulated in lesional psoriatic skin.
The British journal of dermatology, 2012The p38 mitogen-activated protein kinase (MAPK) plays an important role in inflammatory processes and displays increased activity in psoriasis. Dual-specificity phosphatase 1 (DUSP1) is an important negative regulator of p38 MAPK activity.To study mRNA expression of DUSP1 in normal human epidermal keratinocytes (NHEKs) stimulated with proinflammatory ...
Kjellerup, R B +3 more
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British Journal of Dermatology
Abstract Background Dual specificity phosphatase 1 (DUSP1) has recently been shown to regulate keratinocyte (KC) proliferation through extracellular regulated kinase (ERK) signalling. Objectives To delineate the genetic basis ...
Kiril Malovitski +14 more
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Abstract Background Dual specificity phosphatase 1 (DUSP1) has recently been shown to regulate keratinocyte (KC) proliferation through extracellular regulated kinase (ERK) signalling. Objectives To delineate the genetic basis ...
Kiril Malovitski +14 more
openaire +2 more sources
DUSP9, a Dual-Specificity Phosphatase with a Key Role in Cell Biology and Human Diseases
International Journal of Molecular Sciences, 2021Fatma Zohra Khoubai +1 more
exaly