Results 1 to 10 of about 3,339 (149)

Combined therapy with dutasteride and tadalafil vs dutasteride or tadalafil monotherapy in benign prostatic hyperplasia: a randomised phase III trial. [PDF]

BJU Int
Objectives To evaluate the efficacy and safety of a fixed‐dose combination (FDC) of dutasteride and tadalafil vs monotherapy in patients with benign prostatic hyperplasia (BPH). Patients and Methods This phase III trial enrolled 667 patients. After screening and washout, eligible patients were stratified by the baseline International Prostate Symptom ...
Lee SW, Lee SH, Kim JH, Noh JH, Lee JH, Ha US, Oh CY, Kang TW, Lee G, Lee S, Han DH, Han JH, Song SH, Park HJ, Chung BH, Min GE, Jeong IG, Moon KH, Kim WT, Lee JY, Kim CS.   +20 more
europepmc   +2 more sources

The effects of dutasteride and tamsulosin, alone or in association, in the kidney morphology: experimental study in rats [PDF]

Acta Cirúrgica Brasileira
Purpose: To evaluate the renal morphology after isolated and combined administration of dutasteride and tamsulosin in rats. Methods: Forty male rats were divided in groups: control group; D, receiving 0.5 mg/kg/day of dutasteride; T, receiving 0.4 mg/kg/
Marcello Henrique Araujo da Silva, Simone Gomes Ferreira, Bianca Martins Gregório, Francisco José Sampaio, Diogo Benchimol de Souza   +4 more
doaj   +3 more sources

Effects of dutasteride with Bacillus Calmette-Guérin therapy on recurrence, progression, metastasis, and survival in non-muscle invasive bladder cancer: a retrospective single-center study [PDF]

BMC Urology
Background To evaluate the impact of dutasteride, a 5-alpha reductase inhibitor, used alongside intravesical Bacillus Calmette-Guérin therapy on recurrence, progression, metastasis, and disease-free survival in non-muscle invasive bladder cancer patients.
Ali Nebioğlu, Mert Başaranoğlu, Murat Bozlu, Mesut Tek, Erdem Akbay   +4 more
doaj   +2 more sources

Interventions for patients with prostate cancer on active surveillance: a narrative review. [PDF]

BJU Int
Objective To examine contemporary evidence supporting non‐surgical interventions for patients with early prostate cancer (PCa) on active surveillance (AS). Methods A literature search was conducted using the databases PubMed, Medline, and Embase in January 2024 to identify relevant articles published from 2011 onwards.
Gill S, Chen R, Lamb BW, Moore CM, Catto JWF, Cuzick J, Sasieni PD, Rajan P.   +7 more
europepmc   +2 more sources

Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From the United States Food and Drug Administration Adverse Event Reporting System. [PDF]

Int J Dermatol
ABSTRACT Background The United States Food and Drug Administration (FDA) approved oral finasteride for androgenetic alopecia. In 2022, approximately 2.6 million U.S. men used it for hair loss and prostate conditions. Post‐finasteride syndrome (PFS), proposed in 2012, involves persistent sexual and neuropsychiatric adverse events (AEs) after cessation ...
Gupta AK, Talukder M, Keene SA, Bamimore MA.   +3 more
europepmc   +2 more sources

The role of 5-alpha reductase inhibitors in transurethral resection of the prostate: a meta-analysis of randomised controlled trials. [PDF]

BJU Int
Objective To critically evaluate the existing evidence base surrounding the efficacy of preoperative 5‐alpha reductase inhibitor (5ARI) administration in the reduction of perioperative complication rates in transurethral resection of prostate (TURP). Methods In April 2025, a systematic search of on‐line databases was conducted to identify randomised ...
Hehir CM, Calpin GG, Cullivan O, Daly GR, Dowling GP, Davis NF.   +5 more
europepmc   +2 more sources

Prostate zonal impact of 5α-reductase inhibitors on multiparametric MRI characteristics and detection of prostate cancer. [PDF]

BJU Int
Objectives To assess the impact of 5α‐reductase inhibitors (5‐ARIs) on multiparametric magnetic resonance imaging (mpMRI) features of Prostate Imaging‐Reporting and Data System (PI‐RADS) lesions and their influence on the detection of clinically significant prostate cancer (csPCa), with a focus on differences between prostate zones.
Das A, Bigarella M, Brackman K, Allen GO, Rais-Bahrami S, Bahr K, Schmitt E, Fang AM, Boudreau H, Filson CP, Pectasides M, Toia GV, Jarrard DF.   +12 more
europepmc   +2 more sources

Dehydroepiandrosterone Decline in Aging Males as a Predictor of Erectile Dysfunction and Mood Disorders in Patients With Benign Prostate Hyperplasia Undergoing Dutasteride Treatment [PDF]

American Journal of Men's Health
Age-related decline in dehydroepiandrosterone (DHEA) and its sulfate metabolite, dehydroepiandrosterone-sulfate (DHEAS), affects steroid synthesis in men.
Maja Sofronievska Glavinov, Senol Tahir, Stefan Arsov   +2 more
doaj   +2 more sources

Ameliorative potentials of Aju Mbaise extract (AME) on Dutasteride induced oxidative stress and hepatic injury in rats

Journal of Herbal Drugs, 2023
Background & Aim: Aju Mbaise is a polyherbal extract with nutraceutical properties that helps to replenish the volume of blood lost during childbirth and improves breast milk secretion and the general wellbeing of the mother.
Robert Ikechukwu Uroko, Elisha Uko Ogwo , Paul Nweje-Anyalowu , Ikenna Obiwuru, Chinomso Friday Aaron, Obinna Joseph Mba   +5 more
doaj   +1 more source

Peripheral Neuroprotective and Immunomodulatory Effects of 5α-Reductase Inhibitors in Parkinson’s Disease Models

Frontiers in Pharmacology, 2022
Gastrointestinal disorders in Parkinson’s disease (PD) have been associated with neuronal alteration in the plexus of the gut. We previously demonstrated the immunomodulatory effect of female hormones to treat enteric neurodegeneration in the 1-methyl-4 ...
Andrée-Anne Poirier, Andrée-Anne Poirier, Mélissa Côté, Hend Jarras, Hend Jarras, Nadhir Litim, Nadhir Litim, Jérôme Lamontagne-Proulx, Jérôme Lamontagne-Proulx, Sara Al-Sweidi, Sara Al-Sweidi, Marc Morissette, Asmaa Lachhab, Asmaa Lachhab, Martin Pelletier, Martin Pelletier, Thérèse Di Paolo, Thérèse Di Paolo, Denis Soulet, Denis Soulet, Denis Soulet   +20 more
doaj   +1 more source