Results 41 to 50 of about 3,339 (149)

Anti-oncogenic effects of dutasteride, a dual 5-alpha reductase inhibitor and a drug for benign prostate hyperplasia, in bladder cancer

open access: yesJournal of Translational Medicine, 2023
Background The incidence of bladder cancer (BCa) is approximately four times higher in men than in women. To develop effective BCa treatments, there is an urgent need to understand the differences in the BCa control mechanisms based on gender. Our recent
Jaekwon Seok   +6 more
doaj   +1 more source

An exploratory analysis of 5‐alpha reductase inhibitors and risk of opioid use disorder among male Medicare beneficiaries receiving prescription opioid medications

open access: yesThe American Journal on Addictions, Volume 35, Issue 1, Page 46-52, January 2026.
Abstract Background Opioid use disorder (OUD) imposes a significant socioeconomic burden, highlighting the need for new interventions. Objective This study investigated whether exposure to 5‐alpha reductase inhibitors (5αRIs) is associated with a lower risk of developing OUD.
Abdelrahman G. Tawfik   +5 more
wiley   +1 more source

Major revision version 13.0 of the European AIDS Clinical Society guidelines 2025

open access: yesHIV Medicine, Volume 27, Issue 1, Page 18-32, January 2026.
Abstract Background The European AIDS Clinical Society (EACS) guidelines were revised for the 21st time in 2025, with updates covering all aspects of HIV care. Key Points of the Guidelines Update The structure of the guidelines has been reorganized into two parts: Part I focuses on the management and prevention of HIV and related infections, and Part ...
Juan Ambrosioni   +19 more
wiley   +1 more source

The role of dutasteride in reducing complications of transurethral resection of prostate [PDF]

open access: yesAl Ameen Journal of Medical Sciences
Purpose: To evaluate the superiority of dutasteride over a placebo in patients having their prostate removed during transurethral resection for benign prostate hyperplasia. Material and Methods: The study included a total of 30 patients, with 15 patients
Shyamal Shah, P. Periasamy
doaj  

Efficacy, safety, and adverse effects of finasteride and dutasteride in treating benign prostatic hyperplasia: A retrospective cohort study

open access: yesZanco Journal of Medical Sciences
Background and objective: Symptomatic benign prostatic hyperplasia (BPH) results in several symptoms including the lower urinary tract symptoms. Consequently, BPH may affect the bladder and finally the kidneys.
Wishyar Jamal Al-Bazzaz
doaj   +1 more source

Early dutasteride monotherapy in men with detectable serum prostate-specific antigen levels following radical prostatectomy: A prospective trial [PDF]

open access: yesInvestigative and Clinical Urology, 2017
Purpose: To investigate the effects of early administration of dutasteride in patients with detectable serum prostate-specific antigen (PSA) levels after radical prostatectomy (RP).
Yu Seob Shin   +4 more
doaj   +1 more source

Long‐Term Efficacy and Safety of Low‐Level Laser Therapy for Androgenetic Alopecia: A 12‐Month Prospective Trial

open access: yesDermatologic Therapy, Volume 2026, Issue 1, 2026.
Background Low‐level laser therapy (LLLT) has emerged as a nonpharmacologic intervention for androgenetic alopecia (AGA), but evidence on its long‐term efficacy remains limited. Objective To evaluate the 12‐month effectiveness and safety of a home‐use helmet‐type LLLT device in individuals with AGA.
Jung-Won Shin   +5 more
wiley   +1 more source

Molecular Insights Into Repurposed Drug Interactions With HDAC11 for Advancing Epigenetic Therapeutics in Cancer and Neurodegenerative Diseases

open access: yesJournal of Chemistry, Volume 2026, Issue 1, 2026.
Histone deacetylase 11 (HDAC11) is a member of the HDAC family that plays a crucial role in epigenetic regulation, influencing key cellular processes like transcription, differentiation, and proliferation. Abnormal expressions and functions of HDAC11 have been described in various diseases, including neurodegenerative diseases and cancer, highlighting ...
Yinsheng Yang   +5 more
wiley   +1 more source

Efficacy and Safety of a 5-Alpha Reductase Inhibitor, Dutasteride, Added to Bacillus Calmette-Guérin Immunotherapy for Prevention of Recurrence and Progression of Intermediate- and High-Risk Non- Muscle Invasive Bladder Cancer: A Single-Arm, Phase 2 Clinical Trial

open access: yesJournal of Urological Surgery, 2023
Objective:To assess the efficacy and safety of 5α-R inhibitor dutasteride added to standard Bacillus Calmette-Guérin (BCG) immunotherapy for preventing recurrence and progression in intermediate- and high-risk non-muscle invasive bladder cancer (NMIBC ...
Müslim Doğan Değer   +9 more
doaj   +1 more source

Synthesis of the Abiraterone Derivatives 5α‐ and 5β‐Δ1‐Abiraterone and Structural Determination of an Unknown Metabolite in Human Serum Derived from Oral Abiraterone Acetate

open access: yesChemBioChem, Volume 26, Issue 24, December 11, 2025.
Abiraterone (Abi) acetate, a prostate cancer treatment, is orally administered and hydrolyzed, and multiple metabolites are produced in serum by various enzymes. Two novel Abi derivatives, 5α‐ and 5β‐Δ1‐abiraterone, are synthesized. Then, an unknown metabolite in serum is identified to be 5β‐Δ1‐abiraterone based on its extracted ion chromatogram ...
Noboru Hayama   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy