Results 181 to 190 of about 8,973 (210)
EMBO Journal, 2001 Genetic analysis in Drosophila suggests that Bicaudal-D functions in an essential microtubule-based transport pathway, together with cytoplasmic dynein and dynactin.
Casper C Hoogenraad +2 more
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The structure of the dynactin complex and its interaction with dynein [PDF]
Science, 2015 Making a molecular motor fit for purpose Dynactin is an essential cofactor of the microtubule motor, cytoplasmic dynein. Dynactin contains 23 subunits built around a short filament of an actin-related protein (Arp1).
Linas Urnavicius +2 more
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Dynactin is involved in Lewy body pathology
Neuropathology, 2018Dynactin forms a protein complex with dynein that retrogradely transports cargo along microtubules. Dysfunction of this dynein‐dynactin complex causes several neurodegenerative diseases such as Perry syndrome, motor neuron diseases and progressive supranuclear palsy.
Hiroyuki Honda +2 more
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Annual Review of Cell and Developmental Biology, 2004
▪ Abstract Dynactin is a multisubunit protein complex that is required for most, if not all, types of cytoplasmic dynein activity in eukaryotes. Dynactin binds dynein directly and allows the motor to traverse the microtubule lattice over long distances.
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▪ Abstract Dynactin is a multisubunit protein complex that is required for most, if not all, types of cytoplasmic dynein activity in eukaryotes. Dynactin binds dynein directly and allows the motor to traverse the microtubule lattice over long distances.
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Cytoplasmic dynein/dynactin mediates the assembly of aggresomes
Cell Motility, 2002AbstractAggresomes are pericentrosomal cytoplasmic structures into which aggregated, ubiquitinated, misfolded proteins are sequestered. Misfolded proteins accumulate in aggresomes when the capacity of the intracellular protein degradation machinery is exceeded.
Jennifer A, Johnston +2 more
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Dynactin mutations and promises for neurodegenerative pathology
Clinical Genetics, 2009DCTN1 mutations in Perry syndromeFarrer et al.
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1999
Abstract The dynactin molecule as a unit appears to be unique, though it is structurally similar to the short actin filaments that comprise the erythrocyte membrane cytoskeleton. This has led to speculation that the dynactin Arp1 filament might bind membranes via a spectrin network.
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Abstract The dynactin molecule as a unit appears to be unique, though it is structurally similar to the short actin filaments that comprise the erythrocyte membrane cytoskeleton. This has led to speculation that the dynactin Arp1 filament might bind membranes via a spectrin network.
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Dynein and dynactin as organizers of the system of cell microtubules
Russian Journal of Developmental Biology, 2006A review of the role of the microtubule motor dynein and its cofactor dynactin in the formation of a radial system of microtubules in the interphase cells and of mitotic spindle. Deciphering of the structure, functions, and regulation of activity of dynein and dynactin promoted the understanding of mechanisms of cell and tissue morphogenesis, since it ...
A V, Burakov, E S, Nadezhdina
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Dynactin increases the processivity of the cytoplasmic dynein motor
Nature Cell Biology, 1999Cytoplasmic dynein supports long-range intracellular movements of cargo in vivo but does not appear to be a processive motor protein by itself. We show here that the dynein activator, dynactin, binds microtubules and increases the average length of cytoplasmic-dynein-driven movements without affecting the velocity or microtubule-stimulated ATPase ...
S J, King, T A, Schroer
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Organelle Movement: Dynactin: portrait of a dynein regulator
Current Biology, 1994Recent studies of dynactin, a protein complex implicated in regulating the cytoplasmic motor protein dynein, reveal that the complex contains a specialized actin filament and may also interact with microtubules.
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