Results 81 to 90 of about 2,698,470 (299)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Practicality of Dynamic Assessment in Reading Comprehension Strategies and Reading Motivation: Mirroring ESP Students\' Attitudes [PDF]

Iranian Journal of Educational Research
Objective: This study investigated the effects of dynamic assessment (DA) on Iranian ESP university students' reading comprehension strategies and motivation. Furthermore, the views of Iranian ESP university students concerning DA were examined. Methods:
Fatemeh Sharifi, Mehrdad Sepehri, sajad Shafiee   +2 more
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Performance monitoring of MPC based on dynamic principal component analysis

, 2011
A unified framework based on the dynamic principal component analysis (PCA) is proposed for performance monitoring of constrained multi-variable model predictive control (MPC) systems.
Cao, Yuping, Chen, Gongquan, Chen, Sheng, Tian, Xuemin   +3 more
core   +1 more source

MRI in multiple myeloma : a pictorial review of diagnostic and post-treatment findings [PDF]

, 2016
Magnetic resonance imaging (MRI) is increasingly being used in the diagnostic work-up of patients with multiple myeloma. Since 2014, MRI findings are included in the new diagnostic criteria proposed by the International Myeloma Working Group.
A Baur, A Baur-Melnyk, A Stabler, AR Padhani, AR Padhani, AR Padhani, AR Padhani, B Turkbey, BC Vande Berg, C Hayes, C Jakob, C Lavini, C Lin, C Messiou, C Nanni, CM Zechmann, D Smith, DM Koh, E Mena, F Alyas, FE Lecouvet, G Pratt, GP Schmidt, HE Daldrup-Link, J Caers, J Hillengass, J Hillengass, J Hillengass, JC Dutoit, JC Dutoit, JC Dutoit, JR Silva Jr, KL Verstraete, KL Verstraete, LA Moulopoulos, LM Shah, M Fenchel, M Horger, M Merz, MA Dimopoulos, MM Khoo, P Bannas, R Garcia-Figueiras, RA Kyle, S Nosas-Garcia, SL Giles, SV Rajkumar, SV Rajkumar, T Derlin, T Derlin, TM Moehler, Y Zha   +51 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Examining validity in computerized dynamic assessment

ExELL (Explorations in English Language and Linguistics), 2017
Computerized dynamic assessment (CDA) posits itself as a new type of assessment that includes mediation in the assessment process. Proponents of dynamic assessment (DA) in general and CDA in particular argue that the goals of DA are in congruence with ...
Alonazi Zaha
doaj   +1 more source

Assessment for learning and for self-regulation [PDF]

, 2015
Drawing on a research study of formative assessment practices in Irish schools, this paper traces the design, development and pilot of the Assessment for Learning Audit instrument (AfLAi) - a research tool for measuring teachers’ understanding and ...
Lysaght, Zita
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Investigating the role of dynamic assessment on speaking accuracy and fluency of pre-intermediate EFL learners

Cogent Education, 2020
The current study set out to investigate the effect of dynamic assessment (DA) on the speaking accuracy and fluency of pre-intermediate English as a foreign language (EFL) learners. In contrast to static assessment, DA is conceptualized as an interactive
Maryam Safdari, Jalil Fathi
doaj   +1 more source