Results 81 to 90 of about 59,409 (263)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Confirmation of a measurement model for hospital supply chain resilience

Frontiers in Public Health
BackgroundThe hospital supply chain has revealed increasing vulnerabilities and disruptions in the wake of the COVID-19 pandemic, threatening the healthcare services and patient safety.
Baoyang Ding, Baoyang Ding, Xiaohan Yang, Xiaohan Yang, Tiantian Gao, Zheng Liu, Zheng Liu, Qiang Sun, Qiang Sun   +8 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Digital Transformation, Strategic Alignment Capability, and Sustainable Competitive Advantage: The Case of the UAE

Systems
Firms globally are transforming digitally to enhance performance through building differentiated organizational capabilities within their digital ecosystem to maximize value.
Madhad Ali Said Al Jabri, Abdelmounaim Lahrech   +1 more
doaj   +1 more source

ENHANCING INNOVATION CAPABILITY THROUGH PROACTIVE AND RESPONSIVE COMPETITOR ORIENTATION: A DYNAMIC CAPABILITY THEORY PERSPECTIVE

PubBis : Jurnal Pemikiran dan Penelitian Administrasi Publik dan Administrasi Bisnis
BUMDesa has an important role as a driver of the village economy and community empowerment by utilizing local potential and wisdom. However, many BUMDesa still face challenges in adapting to market dynamics and creating relevant innovations. This study aims to examine the effect of proactive and responsive competitor orientations on the innovation ...
null Rosmita, null Septian Wahyudi
openaire   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Navigating the digital transformation path: The role of digital leadership and technological capability through the dynamic capability model

Management şi Marketing
This article explored the impact of digital transformation on enterprise performance and considered how digital leadership can employ an enterprise’s technological capabilities to improve efficiency.
Takyi Kwabena Nsiah, Miloslava Chovancová, Bludo George Yaw, Aloysius Sabog   +3 more
doaj   +1 more source

The Impact of Accountability on Balanced Scorecard Performance of Village-Owned Enterprises: The Mediating Role of Business Model

Jurnal Ilmiah Akuntansi
This study investigates the effect of accountability on the performance of Village-Owned Enterprises (VOEs), with Business Model Innovation (BMI) positioned as a mediating dynamic capability.
Rudy Suryanto, Hafiez Sofyani, Rahmat Darmawan, Tiyas Puji Utami   +3 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source