Results 71 to 80 of about 1,767,706 (293)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Guiding locomotion in complex, dynamic environments [PDF]

Frontiers in Behavioral Neuroscience, 2013
Locomotion in complex, dynamic environments is an integral part of many daily activities, including walking in crowded spaces, driving on busy roadways, and playing sports. Many of the tasks that humans perform in such environments involve interactions with moving objects-that is, they require people to coordinate their own movement with the movements ...
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Non-stationary problem optimization using the primal-dual genetic algorithm [PDF]

This article is posted here with permission from IEEE - Copyright @ 2003 IEEEGenetic algorithms (GAs) have been widely used for stationary optimization problems where the fitness landscape does not change during the computation. However, the environments
Yang, S
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Real-Time Adaptive Target Tracking via Inverse Kinematics Optimization in Stabilized Systems

IEEE Access
To keep a target item inside their field of view, two-axis gimbal systems are designed to dynamically compensate for any movements that may occur, whether such movements originate from the target itself or from the platform on which the device is mounted.
Abderahman Kriouile, Soufiane Hamida, Oussama El Gannour, Abdoul Latif Abdou Moussa   +3 more
doaj   +1 more source

Intelligent Path Planning for AUVs in Dynamic Environments: An EDA-Based Learning Fixed Height Histogram Approach

IEEE Access, 2019
Autonomous underwater vehicles (AUVs) are robots that require path planning to complete missions in different kinds of underwater environments. The goal of path planning is to find a feasible path from the start-point to the target-point in a given ...
Run-Dong Liu, Zong-Gan Chen, Zi-Jia Wang, Zhi-Hui Zhan   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Indoor Positioning Systems as Critical Infrastructure: An Assessment for Enhanced Location-Based Services

Sensors
As the demand for context-aware services in smart environments continues to rise, Indoor Positioning Systems (IPSs) have evolved from auxiliary technologies into indispensable components of mission-critical infrastructure.
Tesfay Gidey Hailu, Xiansheng Guo, Haonan Si   +2 more
doaj   +1 more source