Results 111 to 120 of about 4,209 (249)
Amphiphysin I and regulation of synaptic vesicle endocytosis [PDF]
, 2009 Amphiphysin I, known as a major dynamin-binding partner localized on the collars of nascent vesicles, plays a key role in clathrin-mediated endocytosis (CME) of synaptic vesicles.
Matsui, Hideki +2 more
core +1 more source
Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration [PDF]
, 2018 Research efforts during the last decade have deciphered the basic molecular mechanisms governing mitochondrial fusion and fission. We now know that in mammalian cells mitochondrial fission is mediated by the large GTPase dynamin-related protein 1 (Drp1 ...
Frank, Stephan +3 more
core
Detergent-resistant plasma membrane proteome to elucidate microdomain functions in plant cells [PDF]
, 2013 Although proteins and lipids have been assumed to be distributed homogeneously in the plasma membrane (PM), recent studies suggest that the PM is in fact non-uniform structure that includes a number of lateral domains enriched in specific components (i.e.
Daisuke Takahashi +2 more
core +1 more source
Animal Research and One Health, EarlyView.Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang +8 more
wiley +1 more source
A unique dynamin-related protein is essential for mitochondrial fission in Toxoplasma gondii.
PLoS Pathogens, 2019 The single mitochondrion of apicomplexan protozoa is thought to be critical for all stages of the life cycle, and is a validated drug target against these important human and veterinary parasites.
Carmen Melatti +5 more
doaj +1 more source
Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily [PDF]
, 2017 Mutations in LRRK2 cause autosomal dominant Parkinson's disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase domains, and putative protein-protein interaction domains.
Bandopadhyay, Rina +11 more
core
Biomaterial design strategies for enhancing mitochondrial transplantation therapy
BMEMat, EarlyView.Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang +12 more
wiley +1 more source
PLoS ONE, 2013 BackgroundMature-fruit abscission (MFA) in fleshy-fruit is a genetically controlled process with mechanisms that, contrary to immature-fruit abscission, has not been fully characterized.
Jorge Corbacho +4 more
doaj +1 more source
Dynasore - not just a dynamin inhibitor [PDF]
, 2015 Dynamin is a GTPase protein that is essential for membrane fission during clathrin-mediated endocytosis in eukaryotic cells. Dynasore is a GTPase inhibitor that rapidly and reversibly inhibits dynamin activity, which prevents endocytosis.
James Cronin, Martin Sheldon
core +1 more source
Force stimulation promotes nerve regeneration by restoring cellular energy
BMEMat, EarlyView.Mechanical stimulation can help nerves regenerate in various ways. We developed two devices (a piezo‐motor‐driven stretching device and a SAW‐based actuator) to apply mechanical stimulation to sciatic nerve and DRG neurons. Our study shows that appropriate mechanical force stimulation can promote regeneration by restoring the energy supply to the ...
Zhe Wang +10 more
wiley +1 more source