Results 121 to 130 of about 3,215 (217)
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby +3 more
wiley +1 more source
Hypoxia results in fragmented mitochondria. Whether this fragmentation promotes or prevents cell death is unresolved. Caenorhabditis elegans mutants defective in mitochondrial fission and fusion coupled with a hypoxia resistant Raptor mutant demonstrated that hypoxia‐induced mitochondrial fragmentation occurs without an intact fission machinery and ...
Julien Goldstick +4 more
wiley +1 more source
Mfi2: an outer mitochondrial membrane mitofissin required for mitophagy. [PDF]
Furukawa K +4 more
europepmc +1 more source
Exploring the Shared Genetic Basis of Age at Menopause and Osteoarthritis
Objective The relationship between age at menopause and osteoarthritis (OA) remains unclear. Methods The genetic commonalities between age at menopause and OA were investigated using data from publicly accessible genome‐wide association studies. A variety of methods were employed in this exploration, such as linkage disequilibrium score regression ...
Bingru Luo +3 more
wiley +1 more source
Dynamin independent mechanism of exo-endocytosis coupling. [PDF]
Bandura J, Feng ZP.
europepmc +1 more source
ABSTRACT Small extracellular vesicles (EVs) from bovine milk and whey are emerging as biologically active carriers of microRNA (miRNA), yet their composition and variability among different dairy sources remain incompletely understood. We conducted an integrated characterisation of EV‐associated miRNAs isolated from milk and whey collected from three ...
Caterina Trevisan +3 more
wiley +1 more source
Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An +4 more
wiley +1 more source
Binding of Bacillus subtilis dynamin-like protein DynA to the bacterial membrane is essential for effective phage defense. [PDF]
Shafqat S, Repnik U, Bramkamp M.
europepmc +1 more source
Formulation of Peptide‐Based Nanoparticles Using a Microfluidic Device
A case study using the TAMARA microfluidic device (Inside Therapeutics) was performed for peptide‐based nanoparticles under different operational parameters such as mixing channel geometry, total flow rate, and flow rate ratio. In this context, WRAP5 cell‐penetrating peptide‐based nanoparticles for siRNA or pDNA delivery demonstrated enhanced ...
Thania Hammoum +6 more
wiley +1 more source
ABSTRACT Background Changes in the transcriptome of immune cells are predictive of clinical outcomes. These effects may be surgery‐specific and possibly modulated by glucocorticoids. We investigated the immune response and the impact of dexamethasone on the response in patients undergoing total knee arthroplasty (TKA). Methods The transcript levels (n =
Asger Krog Mølgaard +9 more
wiley +1 more source

