Results 131 to 140 of about 3,215 (217)

Transcriptomic profiling of a commensal Escherichia coli lysogen in simulated intestinal fluid reveals broad changes in both core and accessory regions of the genome. [PDF]

BMC Genomics
Pick K, Raivio TL.
europepmc   +1 more source

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source

The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3. [PDF]

J Neurosci
Hanke-Gogokhia C, Zapadka TE, Finkelstein S, Klingeborn M, Maugel TK, Singer JH, Arshavsky VY, Demb JB.   +7 more
europepmc   +1 more source

The Antidepressant Drug Clomipramine Inhibits the ABC Transporter BmrA

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Drug uptake is constrained by epithelial barriers, such as the intestine and the blood–brain barrier, which express efflux pumps such as the ABC‐transporter ABCB1. Therefore, drugs targeting the central nervous system frequently require co‐administration of efflux inhibitors to facilitate sufficient target engagement. Conversely, certain drugs designed
Nadja Hellmann, Christian Kersten, Thomas Efferth, Dirk Schneider   +3 more
wiley   +1 more source

Dynamin-like Proteins Combine Mechano-constriction and Membrane Remodeling to Enable Two-Step Mitochondrial Fission via a "Snap-through" Instability. [PDF]

J Am Chem Soc
Alimohamadi H, Luo EW, Liu X, Iqbal W, Yang R, Gupta S, Nolden KA, Mandal T, Hill RB, Duan L, Wong GCL.   +10 more
europepmc   +1 more source

Drp1-Dependent Mitochondrial Fission in the Hippocampus Drives Chronic Stress-Induced Depressive-like Behaviors in Mice. [PDF]

Int J Mol Sci
Peng Q, Ai L, Chen C, Zhang J, Sun Q, Gao T, Zhao M, Zhang J.   +7 more
europepmc   +1 more source

Dynamin independent endocytosis is an alternative cell entry mechanism for multiple animal viruses. [PDF]

PLoS Pathog
Ojha R, Jiang A, Mäntylä E, Quirin T, Modhira N, Witte R, Gaudin A, De Zanetti L, Gormal RS, Vihinen-Ranta M, Mercer J, Suomalainen M, Greber UF, Yamauchi Y, Lozach PY, Helenius A, Vapalahti O, Young P, Watterson D, Meunier FA, Joensuu M, Balistreri G.   +21 more
europepmc   +1 more source

DNM2 lipid binding drives centronuclear myopathy and represents a potential therapeutic target. [PDF]

JCI Insight
Gómez-Oca R, Massana-Muñoz X, Reiss D, De Carvalho Neves J, Diedhiou N, Silva-Rojas R, Cowling BS, Goret M, Laporte J.   +8 more
europepmc   +1 more source

DL-3-n-Butylphthalide Protects Against PrP¹⁰⁶ ^-126-Induced Neurotoxicity Through NRF2 Signaling and OPA1/DRP1-Mediated Mitochondrial Dynamics. [PDF]

CNS Neurosci Ther
Wu W, Zhang X, Jiang M, Ma N.
europepmc   +1 more source

Effect of (-)-Epicatechin on Mitochondrial Homeostasis in Skeletal Muscle of Female Obese Rats. [PDF]

Molecules
Herrera-Cogco EC, Herrera-Meza S, Martínez-Meza Y, Pérez-Durán J, Ceballos G, Méndez-Bolaina E, Nájera N.   +6 more
europepmc   +1 more source