Results 131 to 140 of about 3,261 (239)

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

Advanced Science, Volume 13, Issue 45, 13 August 2026.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan, Yixuan Li, Shanan Chen, Pengcheng Du, Kaiwen Wu, Hui Zhang, Kasper Hettinga, Lina Zhang, Gergely Toldi, Fazheng Ren, Yuan Li   +10 more
wiley   +1 more source

Transcriptomic profiling of a commensal Escherichia coli lysogen in simulated intestinal fluid reveals broad changes in both core and accessory regions of the genome. [PDF]

BMC Genomics
Pick K, Raivio TL.
europepmc   +1 more source

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, Volume 13, Issue 45, 13 August 2026.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

AhR activation inhibits DRP1-induced mitochondrial fission in airway smooth muscle during asthma. [PDF]

Am J Respir Cell Mol Biol
Reza MI, Tandberg C, Kumar A, Balraj P, Thompson MA, Prakash YS, Pabelick CM, Britt RD, Sathish V.   +8 more
europepmc   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, Volume 13, Issue 46, 17 August 2026.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Flower Delivery: The Emergence of FLOWER (FWE) as a Multifunctional Regulator of Endo‐Lysosome‐Related Organelle Trafficking Across Cell Types

BioEssays, Volume 48, Issue 8, August 2026.
FLOWER (FWE) is a small alternatively spliced transmembrane protein whose conserved four‐transmembrane topology enables interaction with trafficking machinery and membrane phospholipids. Initially characterized by synaptic vesicle endocytosis, FWE is now recognized as a critical mediator of endo‐lysosome related organelle trafficking across diverse ...
Justin C. Rudd, Laura A. Hansen
wiley   +1 more source

The Neuroprotective Potentials of Dual GIP/GLP1‐RA (Tirzepatide): From Preclinical Experiments to Clinical Trials: A Scoping Review

Brain and Behavior, Volume 16, Issue 8, August 2026.
The graphical abstract summarizes the current evidence on the potential neuroprotective effects of tirzepatide (TZP), a dual GIP/GLP‐1 receptor agonist, across mechanistic, preclinical, and clinical domains. Mechanistically, TZP is proposed to exert direct neural effects, preserve mitochondrial function, reduce apoptosis, oxidative stress, and ...
Yousef Hawas, Mohamed Abouzid, Ahmed Farid Gadelmawla, Dalia Kamal Ewis, Abdallah Khatatbeh, Yasmin Negida, Ahmed Negida   +6 more
wiley   +1 more source

Dynamin-like Proteins Combine Mechano-constriction and Membrane Remodeling to Enable Two-Step Mitochondrial Fission via a "Snap-through" Instability. [PDF]

J Am Chem Soc
Alimohamadi H, Luo EW, Liu X, Iqbal W, Yang R, Gupta S, Nolden KA, Mandal T, Hill RB, Duan L, Wong GCL.   +10 more
europepmc   +1 more source

The Zuo Jin Wan Formula Reverses Cisplatin Resistance in Gastric Cancer by Inhibiting the Mitochondrial Translocation of Dynamin‐Related Protein 1 and Its Mediated Mitochondrial Fission and Mitophagy

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Background Gastric cancer is a major global health concern characterized by high incidence and mortality rates. One of the key challenges in treating gastric cancer is the development of resistance to chemotherapy drugs like cisplatin (DDP). This study aimed to investigate the efficacy of Zuo Jin Wan (ZJW), a traditional Chinese medicine, in ...
Zhuo Zhao, Meijie Yuan, Xiao Yang, Qing Ji, Guobin Liu, Qingfeng Tang, Jian Sun   +6 more
wiley   +1 more source

Ginseng as a Functional Food Intervention for Interstitial Lung Disease: A Review of the Benefits and Molecular Mechanisms

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
From the perspectives of food science and nutrition, this article reviews the regulatory mechanisms through which ginseng and its major components influence ILD‐related pathological processes and discusses its potential as a functional food and future research directions. ABSTRACT Interstitial lung disease (ILD) encompasses a complex group of disorders
Jiahui Li, Guixin Di, Haijiao Wang, Mengzhu Chen, Keju Wang, Ziyuan Wang, Yanxin Li, Tan Wang   +7 more
wiley   +1 more source