Results 141 to 150 of about 4,209 (249)
Analysis of the role of the p47 GTPase IIGP1 in Resistance against Intracellular Pathogens [PDF]
, 2005 IIGP1 is a member of the p47 GTPase family of IFNγ-induced proteins, which are among the most potent presently known mediators of cell-autonomous resistance against intracellular bacterial and protozoan pathogens in the mouse. From all studied members of
Parvanova, Iana Angelova
core
Andrology, EarlyView.Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos +4 more
wiley +1 more source
Mechanisms of action of NME metastasis suppressors - a family affair. [PDF]
Cancer Metastasis Rev, 2023 Prunier C, Chavrier P, Boissan M.
europepmc +1 more source
Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation
Cell Proliferation, EarlyView.Mechanical tension activates Drp1‐mediated mitochondrial fission in macrophages, facilitating the release of Mito‐EVs that are subsequently transferred to BMSCs. Additionally, the CD200R‐CD200 interaction enhances the uptake of these mechanically stimulated macrophage‐derived Mito‐EVs by BMSCs, ultimately promoting osteogenic differentiation.
Yingyi Li +8 more
wiley +1 more source
Vesicle trafficking during somatic cytokinesis [PDF]
, 2008 Van Damme, Daniël +2 more
core +2 more sources
Cell Proliferation, EarlyView.This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang +10 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims Growth differentiation factor 15 (GDF15) has emerged as a promising metabolic regulator with hepatoprotective properties in metabolic dysfunction‐associated steatotic liver disease (MASLD), yet its underlying mechanisms remain elusive.
Jia Li +9 more
wiley +1 more source
European Journal of Haematology, EarlyView.SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley +1 more source
The yeast dynamin-like GTPase Vps1 mediates Atg9 transport to the phagophore assembly site in <i>Saccharomyces cerevisiae</i>. [PDF]
Autophagy Rep, 2023 Hu Y, Reggiori F.
europepmc +1 more source
The FEBS Journal, EarlyView.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source