Results 41 to 50 of about 4,214 (243)

Defective axonal transport in motor neuron disease [PDF]

, 2007
Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas, Blair, Boillee, Bommel, Borchelt, Bowling, Brown, Bruijn, Burger, Cao, Cleveland, Cleveland, Duchen, Escurat, Evans, Fichera, Fliegner, Gaudette, Goldstein, Hadano, Hafezparast, Hazan, Hirokawa, Hirokawa, Hirokawa, Jablonka, Joshi, Kanai, Kaplan, Kieran, King, Kong, LaMonte, Levy, Ligon, Liu, Lo Giudice, Lu, Martin, Miki, Miki, Mitsumoto, Mitsumoto, Muglia, Munch, Nicholson, Nishimura, Okabe, Otomo, Parkinson, Parysek, Pasinelli, Patel, Proukakis, Puls, Puls, Quenneville, Rao, Reid, Reid, Reid, Rosen, Ross, Rowland, Sanderson, Schmitt-John, Shaw, Shibata, Siegel, Song, Teuchert, Troy, Vallee, Weber, Williamson, Wood, Xia, Zhao   +77 more
core   +1 more source

Dynamins at a glance [PDF]

Journal of Cell Science, 2009
The superfamily of dynamins includes classical dynamins and dynamin-related proteins. Classical dynamins are proteins that share sequence similarity with the first described dynamin, which is a large GTPase with five characteristic domains.
Jürgen A W, Heymann, Jenny E, Hinshaw
openaire   +2 more sources

F-actin Bundle Sedimentation Assay

Bio-Protocol, 2019
Understanding the molecular mechanism governing the higher-order regulation of actin dynamics requires chemically-defined and quantitative assays. Recently, the membrane remodeling large GTPase, dynamin, has been identified as a new actin cross-linking ...
Shan-Shan Lin, Mei-Chun Chuang, Ya-Wen Liu   +2 more
doaj   +1 more source

Recruitment of clathrin to intracellular membranes is sufficient for vesicle formation

eLife, 2022
The formation of a clathrin-coated vesicle (CCV) is a major membrane remodeling process that is crucial for membrane traffic in cells. Besides clathrin, these vesicles contain at least 100 different proteins although it is unclear how many are essential ...
Cansu Küey, Méghane Sittewelle, Gabrielle Larocque, Miguel Hernández-González, Stephen J Royle   +4 more
doaj   +1 more source

The 2018 biomembrane curvature and remodeling roadmap [PDF]

, 2018
The importance of curvature as a structural feature of biological membranes has been recognized for many years and has fascinated scientists from a wide range of different backgrounds.
Bashkirov, Pavel V., Bassereau, Patricia, Baumgart, Tobias, Breuer, Artù, Deserno, Markus, Dimova, Rumiana, Frolov, Vadim, Grubmüller, Helmut, Jahn, Reinhard, Jin, Rui, Johannes, Ludger, Kozlov, Michael M., Lauritsen, Line, Lipowsky, Reinhard, Pucadyil, Thomas J., Risselada, H. Jelger, Simon, Camille, Stachowiak, Jeanne C., Stamou, Dimitrios, Sykes, Cécile, Voth, Gregory A., Weikl, Thomas R., Zeno, Wade F.   +22 more
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Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2 [PDF]

, 2017
Gab2 is a large disordered protein that regulates several cellular signalling pathways and is overexpressed in different forms of cancer. Because of its disordered nature, a detailed characterization of the mechanisms of recognition between Gab2 and ...
Bonetti, Daniela, De Simone, Alfonso, Gianni, Stefano, Toto, Angelo   +3 more
core   +3 more sources

Dynamin-like proteins in Trypanosoma brucei: A division of labour between two paralogs? [PDF]

PLoS ONE, 2017
Dynamins and dynamin-like proteins (DLPs) belong to a family of large GTPases involved in membrane remodelling events. These include both fusion and fission processes with different dynamin proteins often having a specialised function within the same ...
Corinna Benz, Eva Stříbrná, Hassan Hashimi, Julius Lukeš   +3 more
doaj   +1 more source

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]

, 2013
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska, AE Topolska, B Lige, B Shen, BF Kafsack, BJ Luft, C Lord, CA Hunter, Chetan E. Chitnis, Christian Slomianny, CY He, D Richard, DL Alexander, F Parussini, H El Hajj, HC Hoppe, HC Hoppe, I Mellman, J Schrevel, JB Dacks, JC Boothroyd, JE Rothman, JF Dubremetz, JM Harper, K Kremer, K Miranda, KA Joiner, KA Joiner, KM Hager, L Pelletier, L Sheiner, LH Bannister, LH Bannister, LM Kats, M Elias, M Tufet-Bayona, M Yang, Markus Meissner, ME Francia, MH Ngo, MH Ngo, MK Shaw, MS Breinich, MS Marks, NA Counihan, PJ Bradley, PJ Sloves, S Mogelsvang, SD Brydges, Stanislas Tomavo, VB Carruthers, Vern B. Carruthers, WM Henne, X Que, Z Dou   +54 more
core   +2 more sources

Platelet granule exocytosis: A comparison with chromaffin cells

Frontiers in Endocrinology, 2013
The rapid secretion of bioactive amines from chromaffin cells constitutes an important component of the fight or flight response of mammals to stress.
Jennifer eFitch-Tewfik, Robert eFlaumenhaft   +1 more
doaj   +1 more source

Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1. [PDF]

, 2020
The fusion of inner mitochondrial membranes requires dynamin-like GTPases, Mgm1 in yeast and OPA1 in mammals, but how they mediate membrane fusion is poorly understood.
Hu, Junjie, Li, Lei, Lou, Zhiyong, Nunnari, Jodi, Qi, Yuanbo, Rao, Zihe, Ricketson, Derek, Sarsam, Reta, Subramanian, Kelly, Wong, Melissa, Wu, Lijie, Yan, Liming, Yu, Caiting, Zhao, Jinghua   +13 more
core