Results 171 to 180 of about 29,365 (193)
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Axonemal dynein from Tetrahymena
Journal of Cell Science, 1991ABSTRACT Axonemal dynein from Tetrahymena cilia can be separated on a sucrose gradient into two fractions, at least one of which appears to be polymorphic. We have been using immuno-electron microscopy in order to try and locate the different types of dynein molecules within the axonemal structure.
E M, Crossley, S C, Hyman, C, Wells
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Journal of Cell Science, 1986
ABSTRACT The structure of dynein isolated from several sources follows the pattern first observed with Tetrahymena 22 S dynein, which has three globular heads attached by three flexible strands to a root-like base. Recent biochemical data indicate that there is one ATPase site on each dynein head and that all three heads interact with ...
K A, Johnson +4 more
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ABSTRACT The structure of dynein isolated from several sources follows the pattern first observed with Tetrahymena 22 S dynein, which has three globular heads attached by three flexible strands to a root-like base. Recent biochemical data indicate that there is one ATPase site on each dynein head and that all three heads interact with ...
K A, Johnson +4 more
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Cytoplasmic dynein in neurodegeneration
Pharmacology & Therapeutics, 2011Cytoplasmic dynein 1 (later referred to as dynein) is the major molecular motor moving cargoes such as mitochondria, organelles and proteins towards the minus end of microtubules. Dynein is involved in multiple basic cellular functions, such as mitosis, autophagy and structure of endoplasmic reticulum and Golgi, but also in neuron specific functions in
Judith, Eschbach, Luc, Dupuis
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Nature Cell Biology, 2008
Individual neurons form specific elaborate dendritic structures that receive presynaptic information. The pattern of dendritic branching is regulated by the microtubule-associated motor protein dynein, which is responsible for the transport of essential endosomes and other organelles into the dendrites.
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Individual neurons form specific elaborate dendritic structures that receive presynaptic information. The pattern of dendritic branching is regulated by the microtubule-associated motor protein dynein, which is responsible for the transport of essential endosomes and other organelles into the dendrites.
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Trends in Cell Biology, 1998
Three classes of cytoskeletal motor protein have been identified--myosins, kinesins and dyneins. Together, these proteins are now thought to be responsible for the remarkable variety of movements that occur in eukaryotic cells and that are essential for reproduction and survival.
R B, Vallee, M A, Gee
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Three classes of cytoskeletal motor protein have been identified--myosins, kinesins and dyneins. Together, these proteins are now thought to be responsible for the remarkable variety of movements that occur in eukaryotic cells and that are essential for reproduction and survival.
R B, Vallee, M A, Gee
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Journal of Cell Science, 2023
ABSTRACT The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as long-range organelle transport in neuronal axons and spindle assembly in dividing cells.
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ABSTRACT The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as long-range organelle transport in neuronal axons and spindle assembly in dividing cells.
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Nature Structural & Molecular Biology, 2011
The mechanisms of dynein activity have remained a mystery because of dynein's size and complexity, but two papers now shed light on how dynein functions at the molecular level.
Neil, Billington, James R, Sellers
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The mechanisms of dynein activity have remained a mystery because of dynein's size and complexity, but two papers now shed light on how dynein functions at the molecular level.
Neil, Billington, James R, Sellers
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Current Opinion in Cell Biology, 2002
Cytoplasmic dynein is a minus end directed microtubule motor protein with numerous functions during interphase and mitosis. Recent evidence has identified several roles mediated by a fraction of cytoplasmic dynein associated with the cell cortex. So far, these include nuclear migration, mitotic spindle orientation, and cytoskeletal reorientation during
Denis L, Dujardin, Richard B, Vallee
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Cytoplasmic dynein is a minus end directed microtubule motor protein with numerous functions during interphase and mitosis. Recent evidence has identified several roles mediated by a fraction of cytoplasmic dynein associated with the cell cortex. So far, these include nuclear migration, mitotic spindle orientation, and cytoskeletal reorientation during
Denis L, Dujardin, Richard B, Vallee
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Nature Cell Biology, 2020
Active transport along microtubules by molecular motors is a crucial cellular process that is disrupted in human diseases. Single-molecule studies from three independent groups reveal a new molecular mechanism for how cells control the activity of the complex microtubule motor cytoplasmic dynein via the neurodevelopmental protein LIS1.
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Active transport along microtubules by molecular motors is a crucial cellular process that is disrupted in human diseases. Single-molecule studies from three independent groups reveal a new molecular mechanism for how cells control the activity of the complex microtubule motor cytoplasmic dynein via the neurodevelopmental protein LIS1.
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1999
Abstract Cytoplasmic dynein is a large, two-headed ATPase which produces force along microtubules in the retrograde direction (toward the microtubufe minus end). It is involved in a wide range of functions, including retrograde axonal transport and mitosis, and it associates with numerous subcellular structures, including kinetochores ...
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Abstract Cytoplasmic dynein is a large, two-headed ATPase which produces force along microtubules in the retrograde direction (toward the microtubufe minus end). It is involved in a wide range of functions, including retrograde axonal transport and mitosis, and it associates with numerous subcellular structures, including kinetochores ...
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