Results 211 to 220 of about 9,978 (230)
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Nature Cell Biology, 2008
Individual neurons form specific elaborate dendritic structures that receive presynaptic information. The pattern of dendritic branching is regulated by the microtubule-associated motor protein dynein, which is responsible for the transport of essential endosomes and other organelles into the dendrites.
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Individual neurons form specific elaborate dendritic structures that receive presynaptic information. The pattern of dendritic branching is regulated by the microtubule-associated motor protein dynein, which is responsible for the transport of essential endosomes and other organelles into the dendrites.
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Trends in Cell Biology, 1998
Three classes of cytoskeletal motor protein have been identified--myosins, kinesins and dyneins. Together, these proteins are now thought to be responsible for the remarkable variety of movements that occur in eukaryotic cells and that are essential for reproduction and survival.
R B, Vallee, M A, Gee
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Three classes of cytoskeletal motor protein have been identified--myosins, kinesins and dyneins. Together, these proteins are now thought to be responsible for the remarkable variety of movements that occur in eukaryotic cells and that are essential for reproduction and survival.
R B, Vallee, M A, Gee
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Journal of Cell Science, 2023
ABSTRACT The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as long-range organelle transport in neuronal axons and spindle assembly in dividing cells.
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ABSTRACT The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as long-range organelle transport in neuronal axons and spindle assembly in dividing cells.
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Nature Structural & Molecular Biology, 2011
The mechanisms of dynein activity have remained a mystery because of dynein's size and complexity, but two papers now shed light on how dynein functions at the molecular level.
Neil, Billington, James R, Sellers
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The mechanisms of dynein activity have remained a mystery because of dynein's size and complexity, but two papers now shed light on how dynein functions at the molecular level.
Neil, Billington, James R, Sellers
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Current Opinion in Cell Biology, 2002
Cytoplasmic dynein is a minus end directed microtubule motor protein with numerous functions during interphase and mitosis. Recent evidence has identified several roles mediated by a fraction of cytoplasmic dynein associated with the cell cortex. So far, these include nuclear migration, mitotic spindle orientation, and cytoskeletal reorientation during
Denis L, Dujardin, Richard B, Vallee
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Cytoplasmic dynein is a minus end directed microtubule motor protein with numerous functions during interphase and mitosis. Recent evidence has identified several roles mediated by a fraction of cytoplasmic dynein associated with the cell cortex. So far, these include nuclear migration, mitotic spindle orientation, and cytoskeletal reorientation during
Denis L, Dujardin, Richard B, Vallee
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Nature Cell Biology, 2020
Active transport along microtubules by molecular motors is a crucial cellular process that is disrupted in human diseases. Single-molecule studies from three independent groups reveal a new molecular mechanism for how cells control the activity of the complex microtubule motor cytoplasmic dynein via the neurodevelopmental protein LIS1.
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Active transport along microtubules by molecular motors is a crucial cellular process that is disrupted in human diseases. Single-molecule studies from three independent groups reveal a new molecular mechanism for how cells control the activity of the complex microtubule motor cytoplasmic dynein via the neurodevelopmental protein LIS1.
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1999
Abstract Cytoplasmic dynein is a large, two-headed ATPase which produces force along microtubules in the retrograde direction (toward the microtubufe minus end). It is involved in a wide range of functions, including retrograde axonal transport and mitosis, and it associates with numerous subcellular structures, including kinetochores ...
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Abstract Cytoplasmic dynein is a large, two-headed ATPase which produces force along microtubules in the retrograde direction (toward the microtubufe minus end). It is involved in a wide range of functions, including retrograde axonal transport and mitosis, and it associates with numerous subcellular structures, including kinetochores ...
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1999
Abstract Axonemal dynein forms a double row of projections, the outer and inner arms, that are attached to the A tubule of each axonemal doublet and extend toward the B tubule of the adjacent doublet.10 The outer dynein arms are distributed along the length of the A tubule, with a constant spacing of 24 nm.
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Abstract Axonemal dynein forms a double row of projections, the outer and inner arms, that are attached to the A tubule of each axonemal doublet and extend toward the B tubule of the adjacent doublet.10 The outer dynein arms are distributed along the length of the A tubule, with a constant spacing of 24 nm.
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Purification of Axonemal Dyneins and Dynein-Associated Components from Chlamydomonas
2009Axonemal dyneins are responsible for generating the force required to power ciliary and flagellar motility. These highly complex enzymes form the inner and outer arms associated with the outer doublet microtubules. They are built around one or more ~520kD heavy chains that exhibit motor activity and also include additional components that are required ...
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