Microiontophoretic Application of Dynorphin in Dental Pain: Excitatory or Inhibitory Effects [PDF]
Journal of Pain ResearchSeung-Ho Choi,* Yu-Mi Kim,* Jo-Young Son, Dong-Kuk Ahn Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea*These authors contributed equally to this workCorrespondence: Dong-Kuk Ahn, Department of ...
Choi SH, Kim YM, Son JY, Ahn DK
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eLife, 2021 Many signal transduction systems have an apparent redundancy built into them, where multiple physiological agonists activate the same receptors. Whether this is true redundancy, or whether this provides an as-yet unrecognized specificity in downstream ...
Jennifer M Kunselman +4 more
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Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor [PDF]
Nature CommunicationsThe endogenous opioid system provides powerful control over emotions, nociception, and motivation among many other fundamental nervous system functions.
Xiaona Li +10 more
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Enhanced dynorphin expression and secretion in pancreatic beta-cells under hyperglycemic conditions [PDF]
Molecular MetabolismObjective: Dynorphin, an endogenous opioid peptide predominantly expressed in the central nervous system and involved in stress response, pain, and addiction, has intrigued researchers due to its expression in pancreatic β-cells.
Miranda Movahed +2 more
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PLoS ONE, 2009 Stress is a complex human experience and having both rewarding and aversive motivational properties. The adverse effects of stress are well documented, yet many of underlying mechanisms remain unclear and controversial. Here we report that the anxiogenic
Michael R Bruchas +3 more
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Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor [PDF]
Journal of Neuroinflammation, 2018 Background We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials.
Duy-Khanh Dang +12 more
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Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators [PDF]
Nature CommunicationsG-protein coupled receptors help regulate cellular function and communication, and are targets of small molecule drug discovery efforts. Conventional techniques to probe these interactions require labels and large amounts of receptor to achieve ...
Adley Gin +6 more
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A Bicyclic Analog of the Linear Peptide Arodyn Is a Potent and Selective Kappa Opioid Receptor Antagonist [PDF]
MoleculesKappa opioid receptor (KOR) antagonists have potential therapeutic applications in the treatment of stress-induced relapse to substance abuse and mood disorders.
Solomon A. Gisemba +3 more
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Role of movement in long-term basal ganglia changes: implications for abnormal motor responses [PDF]
Frontiers in Computational Neuroscience, 2013 Abnormal involuntary movements and dyskinesias elicited by drugs that stimulate dopamine receptors in the basal ganglia are a major issue in the management of Parkinson’s disease (PD).
Nicola eSimola +6 more
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Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2012 Melinda A. Mittelman-Smith +4 more
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