Results 1 to 10 of about 18,642 (255)

Microiontophoretic Application of Dynorphin in Dental Pain: Excitatory or Inhibitory Effects [PDF]

Journal of Pain Research
Seung-Ho Choi,* Yu-Mi Kim,* Jo-Young Son, Dong-Kuk Ahn Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea*These authors contributed equally to this workCorrespondence: Dong-Kuk Ahn, Department of ...
Choi SH, Kim YM, Son JY, Ahn DK
doaj   +2 more sources

Enhanced dynorphin expression and secretion in pancreatic beta-cells under hyperglycemic conditions [PDF]

Molecular Metabolism
Objective: Dynorphin, an endogenous opioid peptide predominantly expressed in the central nervous system and involved in stress response, pain, and addiction, has intrigued researchers due to its expression in pancreatic β-cells.
Miranda Movahed, Ruy A. Louzada, Manuel Blandino-Rosano   +2 more
doaj   +2 more sources

Shifted Balance Between Ventral Striatal Prodynorphin and Proenkephalin Biases Development of Cocaine Place Avoidance. [PDF]

Addict Biol
We examined the optimum parameters for producing conditioned place avoidance (CPA) to the acutely aversive effects of cocaine treatment. We discovered that individual differences, rather than cocaine dose, apparatus type, stimulus modality or conditioning time, were important for expression of cocaine CPA.
Nicot A, Yecham P, Serin I, Barker DJ, Dobbs LK.   +4 more
europepmc   +2 more sources

Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor [PDF]

Journal of Neuroinflammation, 2018
Background We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials.
Duy-Khanh Dang, Eun-Joo Shin, Dae-Joong Kim, Hai-Quyen Tran, Ji Hoon Jeong, Choon-Gon Jang, Seung-Yeol Nah, Jung Hwan Jeong, Jae Kyung Byun, Sung Kwon Ko, Guoying Bing, Jau-Shyong Hong, Hyoung-Chun Kim   +12 more
doaj   +4 more sources

Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators [PDF]

Nature Communications
G-protein coupled receptors help regulate cellular function and communication, and are targets of small molecule drug discovery efforts. Conventional techniques to probe these interactions require labels and large amounts of receptor to achieve ...
Adley Gin, Phuong-Diem Nguyen, Jeffrey E. Melzer, Cheng Li, Hannah Strzelinski, Stephen B. Liggett, Judith Su   +6 more
doaj   +2 more sources

A Bicyclic Analog of the Linear Peptide Arodyn Is a Potent and Selective Kappa Opioid Receptor Antagonist [PDF]

Molecules
Kappa opioid receptor (KOR) antagonists have potential therapeutic applications in the treatment of stress-induced relapse to substance abuse and mood disorders.
Solomon A. Gisemba, Michael J. Ferracane, Thomas F. Murray, Jane V. Aldrich   +3 more
doaj   +2 more sources

Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis [PDF]

Scientific Reports
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 5–20% of reproductive-age women. However, the treatment of PCOS is mainly based on symptoms and not on its pathophysiology.
Gita Pratama, Budi Wiweko, Asmarinah, Indah S. Widyahening, Trinovita Andraini, Hartanto Bayuaji, Andon Hestiantoro   +6 more
doaj   +2 more sources

Altered expression of kisspeptin, dynorphin, and related neuropeptides in polycystic ovary syndrome: A cross-sectional study [PDF]

International Journal of Reproductive BioMedicine
Background: Since kisspeptin (KISS1) in the hypothalamus is affected by the inhibitory effect of dynorphin, it raises questions about the controlled balance of these 2 neuropeptides in women with and without polycystic ovary syndrome (PCOS).
Andon Hestiantoro, Rachellina Noor Al Maghfira, Ratna Fathmasari, Ririn Rahmala Febri, Ericko Ongko Joyo, Raden Muharam, Gita Pratama, Anom Bowolaksono   +7 more
doaj   +2 more sources

Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides

eLife, 2021
Many signal transduction systems have an apparent redundancy built into them, where multiple physiological agonists activate the same receptors. Whether this is true redundancy, or whether this provides an as-yet unrecognized specificity in downstream ...
Jennifer M Kunselman, Achla Gupta, Ivone Gomes, Lakshmi A Devi, Manojkumar A Puthenveedu   +4 more
doaj   +1 more source

SEQUENCE ANALYSIS SUGGESTS POSITIVE SELECTION ON THE BOVINE PRODYNORPHIN GENE [PDF]

BAG. Journal of Basic and Applied Genetics, 2020
Dynorphin A is an endogenous opioid peptide that is part of the KNDy system in the hypothalamus of mammals. This peptide acts as an inhibitor of the GnRH pulse generation, thus regulating the onset of puberty and reproductive cycles.
Suqueli García M.F., Castellote M.A., Corva P.M.   +2 more
doaj   +1 more source