Drug-Related Engrams and Their Role in the Persistence and Recurrence of Drug-Related Behaviors. [PDF]
HippocampusABSTRACT Memory is a cornerstone of human behavior, and addiction offers a compelling model of its persistence and plasticity. The scope of engram research has rapidly expanded to include addiction‐related phenomena. Addiction‐related memories, like strong aversive memories, are often highly resistant to extinction and can continue to drive relapse ...
Cutler M, Thati A, Grella SL.
europepmc +2 more sources
eLife, 2021 Many signal transduction systems have an apparent redundancy built into them, where multiple physiological agonists activate the same receptors. Whether this is true redundancy, or whether this provides an as-yet unrecognized specificity in downstream ...
Jennifer M Kunselman +4 more
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Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep
Biology, 2021 The neural mechanisms underlying increases in gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion that drive puberty onset are unknown.
Eliana G. Aerts +6 more
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SEQUENCE ANALYSIS SUGGESTS POSITIVE SELECTION ON THE BOVINE PRODYNORPHIN GENE [PDF]
BAG. Journal of Basic and Applied Genetics, 2020 Dynorphin A is an endogenous opioid peptide that is part of the KNDy system in the hypothalamus of mammals. This peptide acts as an inhibitor of the GnRH pulse generation, thus regulating the onset of puberty and reproductive cycles.
Suqueli García M.F. +2 more
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Dynorphin, stress, and depression [PDF]
Brain Research, 2010 Stress is most often associated with aversive states. It rapidly induces the release of hormones and neuropeptides including dynorphin, which activates kappa opioid receptors (KORs) in the central and peripheral nervous systems. In animal models, many aversive effects of stress are mimicked or exacerbated by stimulation of KORs in limbic brain regions.
Allison T. Knoll, William A. Carlezon
openaire +3 more sources
Cell & Bioscience, 2020 Background Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for mitigating ...
Lin Liu +5 more
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Distribution and regulation of gonadotropin-releasing hormone, kisspeptin, RF-amide related peptide-3, and dynorphin in the bovine hypothalamus [PDF]
PeerJ, 2016 Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the arcuate nucleus (ARC) play a key role in gonadotropin-releasing hormone (GnRH) pulse generation and gonadal steroid feedback, with kisspeptin driving GnRH ...
Valeria M. Tanco +5 more
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Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line [PDF]
, 2013 Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated
A Breit +73 more
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Neurobiology of Disease, 2006 Up to 89% of patients with herpes simplex virus type-1 (HSV-1) encephalitis can have seizures. Possibly, viruses are environmental triggers for seizures in genetically vulnerable individuals. Inherited dynorphin promoter polymorphisms are associated with
Marylou V. Solbrig +3 more
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A quantitative study of neurochemically-defined populations of inhibitory interneurons in the superficial dorsal horn of the mouse spinal cord [PDF]
, 2017 Around a quarter of neurons in laminae I-II of the dorsal horn are inhibitory interneurons. These play an important role in modulating somatosensory information, including that perceived as pain or itch.
Boyle, Kieran A. +7 more
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