Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit
Cell Reports, 2016 Kappa opioid receptors (KORs) are involved in a variety of aversive behavioral states, including anxiety. To date, a circuit-based mechanism for KOR-driven anxiety has not been described.
Nicole A. Crowley +13 more
doaj +2 more sources
Modulatory effects of orexin and dynorphin on stress-related alcohol seeking and relapse: pivotal role of the posterior paraventricular nucleus of the thalamus [PDF]
Frontiers in PharmacologyAlcohol use disorder (AUD) remains a significant problem in the United States, resulting in over 178,000 alcohol-related deaths annually. A central problem in treating AUD is the high rate of relapse to alcohol use even after protracted periods of ...
Gabriel Holguin, Rémi Martin-Fardon
doaj +2 more sources
Co‐Expression of Tardive Dyskinesia and Drug‐Induced Parkinsonism in Rats Chronically Treated With Haloperidol [PDF]
Neuropsychopharmacology ReportsAim We aimed to create a rat model of drug‐induced parkinsonism and tardive dyskinesia by chronic administration of haloperidol and examine the expression of direct and indirect pathway markers in the striatum of the model rats.
Iku Kinoshita +7 more
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A Bicyclic Analog of the Linear Peptide Arodyn Is a Potent and Selective Kappa Opioid Receptor Antagonist [PDF]
MoleculesKappa opioid receptor (KOR) antagonists have potential therapeutic applications in the treatment of stress-induced relapse to substance abuse and mood disorders.
Solomon A. Gisemba +3 more
doaj +2 more sources
The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective
Annual Review of Pharmacology and Toxicology, 2016 Tony L Yaksh, Vivian Hook
exaly +2 more sources
Dysregulated Plasticity in Serotonin, Galanin, and Opioid Systems Contributes to Limbic Seizure Recruitment in Wistar Audiogenic Rat. [PDF]
J NeurochemTo find molecular reasons why a genetic rat model (Wistar Audiogenic Rat, WAR) moves from sound‐triggered brainstem seizures to longer‐lasting limbic (temporal‐lobe) epilepsy after repeated loud‐noise exposure. WAR and normal Wistar rats received a 10‐day audiogenic kindling (twice‐daily loud noise).
Camilo TA +6 more
europepmc +2 more sources
Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward
Neuron, 2015 Ream Al-Hasani +2 more
exaly +2 more sources
Neuropsychopharmacology, 2021 Reward and reinforcement processes are critical for survival and propagation of genes. While numerous brain systems underlie these processes, a cardinal role is ascribed to mesolimbic dopamine.
Catherine S. Thomas +5 more
semanticscholar +1 more source
Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep
Biology, 2021 The neural mechanisms underlying increases in gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion that drive puberty onset are unknown.
Eliana G. Aerts +6 more
doaj +1 more source
SEQUENCE ANALYSIS SUGGESTS POSITIVE SELECTION ON THE BOVINE PRODYNORPHIN GENE [PDF]
BAG. Journal of Basic and Applied Genetics, 2020 Dynorphin A is an endogenous opioid peptide that is part of the KNDy system in the hypothalamus of mammals. This peptide acts as an inhibitor of the GnRH pulse generation, thus regulating the onset of puberty and reproductive cycles.
Suqueli García M.F. +2 more
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