Results 51 to 60 of about 18,529 (254)

Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bonds

eLife, 2016
Prairie vole breeder pairs form monogamous pair bonds, which are maintained through the expression of selective aggression toward novel conspecifics.
Shanna L Resendez, Piper C Keyes, Jeremy J Day, Caely Hambro, Curtis J Austin, Francis K Maina, Lori N Eidson, Kirsten A Porter-Stransky, Natalie Nevárez, J William McLean, Morgan A Kuhnmuench, Anne Z Murphy, Tiffany A Mathews, Brandon J Aragona   +13 more
doaj   +1 more source

Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction

Frontiers in Endocrinology, 2021
Increasing evidence accumulated during the past two decades has demonstrated that the then-novel kisspeptin, which was discovered in 2001, the known neuropeptides neurokinin B and dynorphin A, which were discovered in 1983 and 1979, respectively, and ...
Yoshihisa Uenoyama, Mayuko Nagae, Hitomi Tsuchida, Naoko Inoue, Hiroko Tsukamura   +4 more
doaj   +1 more source

Oligodendrogenesis in Evolution, Development and Adulthood

Glia, EarlyView.
Oligodendrocytes and myelin took shape in jawed vertebrates. During development, OPCs are originated from NSCs and then undergo differentiation into mature oligodendrocytes that supply myelin. OPCs persist in the adult CNS and continue to produce oligodendrocytes and myelin. Adaptive myelination, which fine‐tunes neural circuits in response to neuronal
Hao Hu, Tianhao Gao, Jingwei Zhao, Huiliang Li   +3 more
wiley   +1 more source

Isolation and amino acid sequence analysis of a 4,000-dalton dynorphin from porcine pituitary [PDF]

, 1982
A 4,000-dalton dynorphin was isolated from porcine pituitary. It has 32 amino acids (Mr = 3,986), with the previously described heptadecapeptide (now called dynorphin A) at its amino terminus and a related tridecapeptide, dynorphin B, at its carboxyl ...
Fischli, Walter, Goldstein, Avram, Hood, Leroy E., Hunkapiller, Michael W.   +3 more
core  

Functional differences between neurochemically defined populations of inhibitory interneurons in the rat spinal dorsal horn [PDF]

, 2013
In order to understand how nociceptive information is processed in the spinal dorsal horn we need to unravel the complex synaptic circuits involving interneurons, which constitute the vast majority of the neurons in laminae I–III. The main limitation has
Locke, S., Polgár, Erika, Sardella, T.C.P., Tiong, S.Y.X., Todd, A.J., Watanabe, M.   +5 more
core   +1 more source

Mechanism and site of action of big dynorphin on ASIC1a [PDF]

Proceedings of the National Academy of Sciences, 2019
Acid-sensing ion channels (ASICs) are proton-gated cation channels that contribute to neurotransmission, as well as initiation of pain and neuronal death following ischemic stroke. As such, there is a great interest in understanding the in vivo regulation of ASICs, especially by endogenous neuropeptides that potently modulate ASICs.
Borg, Christian B., Braun, Nina, Heusser, Stephanie A., Bay, Yasmin, Weis, Daniel, Galleano, Iacopo, Lund, Camilla, Tian, Weihua, Haugaard-Kedström, Linda M., Bennett, Eric P., Lynagh, Timothy, Strømgaard, Kristian, Andersen, Jacob, Pless, Stephan A.   +13 more
openaire   +7 more sources

Physiologically Based Pharmacokinetic (PBPK) Model to Predict the Magnitude of Drug–Drug Interaction Between Fezolinetant and CYP1A2 Inhibitors

The Journal of Clinical Pharmacology, EarlyView.
Abstract Fezolinetant is a non‐hormonal, selective neurokinin 3 receptor antagonist approved in multiple countries including the United States, in Europe, and in Asia for the treatment of moderate to severe vasomotor symptoms in menopausal women. Fezolinetant is primarily metabolized by CYP1A2 and was found to be a sensitive substrate for CYP1A2 ...
Mary P. Choules, Yukio Otsuka, Jace C. Nielsen, Megumi Iwai, Peter L. Bonate   +4 more
wiley   +1 more source

Increased bradykinesia in Parkinson’s disease with increased movement complexity: elbow flexion-extension movements [PDF]

, 2008
The present research investigates factors contributing to bradykinesia in the control of simple and complex voluntary limb movement in Parkinson’s disease (PD) patients.
Geelen, J.A.G., Heida, Tjitske, Moroney, Rachel, Rinzel, J.   +3 more
core   +4 more sources

Effects of Aging on Levo-Dihydroxyphenylalanine- Induced Dyskinesia in a Rat Model of Parkinson’s Disease

Frontiers in Aging Neuroscience, 2021
BackgroundIt remains unclear why patients with young-onset Parkinson’s disease more often develop levo-dihydroxyphenylalanine (L-dopa)-induced dyskinesia (LID) and have a more severe form than patients with old-onset Parkinson’s disease. Previous studies
Haruo Nishijima, Tamaki Kimura, Fumiaki Mori, Koichi Wakabayashi, Iku Kinoshita, Takashi Nakamura, Tomoya Kon, Chieko Suzuki, Masahiko Tomiyama   +8 more
doaj   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source