Results 51 to 60 of about 23,034 (262)

On the G-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation [PDF]

, 2013
The modulatory role of allosteric receptor-receptor interactions in the pain pathways of the Central Nervous System and the peripheral nociceptors has become of increasing interest.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Fuxe, Kjell, Rivera, Alicia, Romero-Fernandez, Wilber, Tarakanov, Alexander O, Van Craenenbroeck, Kathleen   +6 more
core   +3 more sources

High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons

eLife, 2016
Kisspeptin (Kiss1) and neurokinin B (NKB) neurocircuits are essential for pubertal development and fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus (Kiss1ARH) co-express Kiss1, NKB, dynorphin and glutamate and are postulated to provide ...
Jian Qiu, Casey C Nestor, Chunguang Zhang, Stephanie L Padilla, Richard D Palmiter, Martin J Kelly, Oline K Rønnekleiv   +6 more
doaj   +1 more source

Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides

Biomedicines, 2021
Mutations in the prodynorphin gene (PDYN) are associated with the development of spinocerebellar ataxia type 23 (SCA23). Pathogenic missense mutations are localized predominantly in the PDYN region coding for the dynorphin A (DynA) neuropeptide and lead ...
Andreas Lieb, Germana Thaler, Barbara Fogli, Olga Trovato, Mitja Amon Posch, Teresa Kaserer, Luca Zangrandi   +6 more
doaj   +1 more source

Orexin (Hypocretin) Neurons Contain Dynorphin [PDF]

The Journal of Neuroscience, 2001
Orexins (also called hypocretins) are peptide neurotransmitters expressed in neurons of the lateral hypothalamic area (LHA). Mice lacking the orexin peptides develop narcolepsy-like symptoms, whereas mice with a selective loss of the orexin neurons develop hypophagia and severe obesity in addition to the narcolepsy phenotype. These different phenotypes
T C, Chou, C E, Lee, J, Lu, J K, Elmquist, J, Hara, J T, Willie, C T, Beuckmann, R M, Chemelli, T, Sakurai, M, Yanagisawa, C B, Saper, T E, Scammell   +11 more
openaire   +2 more sources

Cocaine Dysregulates Dynorphin Modulation of Inhibitory Neurotransmission in the Ventral Pallidum in a Cell-Type-Specific Manner

Journal of Neuroscience, 2019
Cocaine-driven changes in the modulation of neurotransmission by neuromodulators are poorly understood. The ventral pallidum (VP) is a key structure in the reward system, in which GABA neurotransmission is regulated by opioid neuropeptides, including ...
Kineret Inbar, Liran A Levi, Nimrod Bernat, Tal Odesser, D. Inbar, Y. Kupchik   +5 more
semanticscholar   +1 more source

Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects

Frontiers in Pharmacology, 2021
Addiction to cocaine is associated with dysfunction of the dopamine mesocortical system including impaired dopamine-2 receptor (D2r) signaling. However, the effects of chronic cocaine on neuronal adaptations in this system have not been systematically ...
Kevin Clare, Chelsea Pan, Gloria Kim, Kicheon Park, Juan Zhao, Nora D. Volkow, Zhicheng Lin, Congwu Du   +7 more
doaj   +1 more source

Increased bradykinesia in Parkinson’s disease with increased movement complexity: elbow flexion-extension movements [PDF]

, 2008
The present research investigates factors contributing to bradykinesia in the control of simple and complex voluntary limb movement in Parkinson’s disease (PD) patients.
Geelen, J.A.G., Heida, Tjitske, Moroney, Rachel, Rinzel, J.   +3 more
core   +4 more sources

Dynorphin activation of kappa opioid receptor protects against epilepsy and seizure-induced brain injury via PI3K/Akt/Nrf2/HO-1 pathway

Cell Cycle, 2018
Dynorphins act as endogenous anticonvulsants via activation of kappa opioid receptor (KOR). However, the mechanism underlying the anticonvulsant role remains elusive.
H. Dai, Peipei Wang, Huafang Mao, Xiao Mao, Shan Tan, Zhiheng Chen   +5 more
semanticscholar   +1 more source

The role of BDNF/TrkB signaling in acute amphetamine-induced locomotor activity and opioid peptide gene expression in the rat dorsal striatum

Frontiers in Systems Neuroscience, 2011
Exposure to psychostimulants increases brain-derived neurotrophic factor (BDNF) mRNA and protein levels in the cerebral cortex and subcortical structures.
Jacqueline F McGinty, Alexandra J Bache, Nortorious T Coleman, Wei-Lun eSun   +3 more
doaj   +1 more source

Avian opioid peptides: evolutionary considerations, functional roles and a challenge to address critical questions

Frontiers in Physiology, 2023
The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec, Colin G. Scanes   +1 more
doaj   +1 more source