Results 61 to 70 of about 16,897 (225)

Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bonds

eLife, 2016
Prairie vole breeder pairs form monogamous pair bonds, which are maintained through the expression of selective aggression toward novel conspecifics.
Shanna L Resendez, Piper C Keyes, Jeremy J Day, Caely Hambro, Curtis J Austin, Francis K Maina, Lori N Eidson, Kirsten A Porter-Stransky, Natalie Nevárez, J William McLean, Morgan A Kuhnmuench, Anne Z Murphy, Tiffany A Mathews, Brandon J Aragona   +13 more
doaj   +1 more source

Vascular health and exercise in females throughout the lifespan: Exploring puberty, pregnancy and menopause

Experimental Physiology, EarlyView.
Abstract This narrative review highlights the impact of exercise on vascular health in females over the lifespan with an emphasis on puberty, pregnancy and menopause. These events encompass substantial changes in sex hormone levels, particularly oestrogens and progesterone.
Kathleen B. Miller, M. Erin Moir, Brandon G. Fico   +2 more
wiley   +1 more source

Membership and behavior of ultra-low-diversity pathogen communities present in the gut of humans during prolonged critical illness. [PDF]

, 2014
UnlabelledWe analyzed the 16S rRNA amplicon composition in fecal samples of selected patients during their prolonged stay in an intensive care unit (ICU) and observed the emergence of ultra-low-diversity communities (1 to 4 bacterial taxa) in 30% of the ...
Alverdy, John C, Garfield, Kevin, Gilbert, Jack A, Kade, Matthew, Quensen, John, Shakhsheer, Baddr, Smith, Daniel, Tiedje, James, Tirrell, Matthew, Zaborin, Alexander, Zaborina, Olga   +10 more
core   +3 more sources

Pharmacology of Kappa Opioid Receptors: Novel Assays and Ligands

Frontiers in Pharmacology, 2022
The present study investigated the in vitro pharmacology of the human kappa opioid receptor using multiple assays, including calcium mobilization in cells expressing chimeric G proteins, the dynamic mass redistribution (DMR) label-free assay, and a ...
Chiara Sturaro, Davide Malfacini, Michela Argentieri, Francine M. Djeujo, Erika Marzola, Valentina Albanese, Chiara Ruzza, Chiara Ruzza, Remo Guerrini, Remo Guerrini, Girolamo Calo’, Paola Molinari   +11 more
doaj   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators

Nature Communications
G-protein coupled receptors help regulate cellular function and communication, and are targets of small molecule drug discovery efforts. Conventional techniques to probe these interactions require labels and large amounts of receptor to achieve ...
Adley Gin, Phuong-Diem Nguyen, Jeffrey E. Melzer, Cheng Li, Hannah Strzelinski, Stephen B. Liggett, Judith Su   +6 more
doaj   +1 more source

l-DOPA-Induced Dyskinesia in the Intrastriatal 6-Hydroxydopamine Model of Parkinson's Disease: Relation to Motor and Cellular Parameters of Nigrostriatal Function

Neurobiology of Disease, 2002
In order to assess the role of striatal dopamine (DA) afferents in l-DOPA-induced dyskinesia, we have studied a large series of rats sustaining 2, 3, or 4 unilateral injections of 6-hydroxydopamine (6-OHDA) in the lateral striatum.
Christian Winkler, Deniz Kirik, Anders Björklund, M.Angela Cenci   +3 more
doaj   +1 more source

Rare but relevant: Ibogaine and cardiovascular complications—prolonged QT interval and ventricular arrhythmias

Addiction, Volume 121, Issue 6, Page 1616-1621, June 2026.
Abstract Revived interest in psychedelic‐assisted therapies has also renewed focus on ibogaine, a psychoactive alkaloid, for its notable anti‐addictive potential. Evidence from observational, open‐label, and limited randomized placebo‐controlled trials indicates that ibogaine and its metabolite noribogaine reduce craving and withdrawal symptoms in ...
Tibor Markus Brunt
wiley   +1 more source

Membrane leakage induced by dynorphins

FEBS Letters, 2006
Dynorphins, endogeneous opioid peptides, function as ligands to the opioid kappa receptors and induce non‐opioid excitotoxic effects. Here we show that big dynorphin and dynorphin A, but not dynorphin B, cause leakage effects in large unilamellar phospholipid vesicles (LUVs).
Hugonin, Loïc, Vukojević, Vladana, Bakalkin, Georgy, Gräslund, Astrid   +3 more
openaire   +2 more sources

Oxytocin‐ und Vasopressin‐Photosonden zur Entschlüsselung der Neuropeptid‐Signalgebung mit hoher räumlicher und zeitlicher Präzision

Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.
Neue biokompatible Oxytocin‐ und Vasopressin‐Photosonden mit modernsten Photocages. Diese Photosonden sind inaktiv und können mit spezifischen Lichtwellen entschützt werden, was eine Rezeptoraktivierung mit hoher zeitlicher und räumlicher Kontrolle ermöglicht. Abbildung erstellt mit https://BioRender.com ZUSAMMENFASSUNG Das Oxytocin/Vasopressin (OT/VP)
Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler   +7 more
wiley   +1 more source