Results 61 to 70 of about 11,182 (207)

Addiction is a reward deficit and stress surfeit disorder

Frontiers in Psychiatry, 2013
Drug addiction can be defined by a three-stage cycle—binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation—that involves allostatic changes in the brain reward and stress systems.
George F Koob
doaj   +1 more source

Role of PBN‐CeA Circuit in Paclitaxel‐Induced Neuropathic Pain and Negative Emotions

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Paclitaxel‐induced neuropathy recruits the PBN–CeA pathway and increases CeA PDYN expression, contributing to pain hypersensitivity and negative emotional behaviors. Suppressing PBN inputs to the CeA or blocking KOR with Navacaprant mitigates both sensory hypersensitivity and negative emotional symptoms.
Huiqin Chen, Liang Chen, Yu Chen, Yin Huang, Fei Fan, YiQian Liu, Qianli Zhang, Ying Tang, Aiqin Chen, Chun Lin   +9 more
wiley   +1 more source

The efficacy of Dynorphin fragments at the kappa, mu and delta opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation

, 2017
Background Dynorphin 1–17 is an endogenous peptide that is released at sites of inflammation by leukocytes, binding preferentially to κ-opioid receptors (KOP) to mediate nociception.
Benhabib, F, Hewavitharana, AK, Heffernan, A, Cabot, PJ, Shaw, PN, Morgan, M, Wagner, S   +6 more
core   +1 more source

Membrane leakage induced by dynorphins

FEBS Letters, 2006
Dynorphins, endogeneous opioid peptides, function as ligands to the opioid kappa receptors and induce non‐opioid excitotoxic effects. Here we show that big dynorphin and dynorphin A, but not dynorphin B, cause leakage effects in large unilamellar phospholipid vesicles (LUVs).
Hugonin, Loïc, Vukojević, Vladana, Bakalkin, Georgy, Gräslund, Astrid   +3 more
openaire   +2 more sources

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, Volume 40, Issue 8, Page 4880-4897, August 2026.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Effects of a kappa opioid receptor antagonist on delayed postoperative pain recovery in a novel mouse sleep disorder model

Frontiers in Pain Research
IntroductionSleep disturbances have been shown to exacerbate pain sensitivity and prolong recovery from pain. However, conventional animal models of sleep disturbance, which involve physical disruptions, such as water or forced movement, might not fully ...
Hisakatsu Ito, Hisakatsu Ito, Masaaki Kawakami, Masashi Yoshida, Sadamu Sugimoto, Tomonori Takazawa   +5 more
doaj   +1 more source

The dopamine D1-D2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in basal ganglia

Frontiers in Neuroanatomy, 2011
Dopaminergic signaling within the basal ganglia has classically been thought to occur within two distinct neuronal pathways; the direct striatonigral pathway which contains the dopamine D1 receptor and the neuropeptides dynorphin and substance P, and the
Melissa L. Perreault, Melissa L. Perreault, Ahmed eHasbi, Ahmed eHasbi, Brian F. O'Dowd, Brian F. O'Dowd, Susan R. George, Susan R. George   +7 more
doaj   +1 more source

Therapeutic potential of spexin in diabetic neuropathy: Insights from in vitro and in vivo models

Experimental Physiology, Volume 111, Issue 8, Page 3800-3817, 1 August 2026.
Abstract The present study investigated the therapeutic potential of spexin (SPX) on both in vitro and in vivo models of diabetic neuropathy (DN). A total of 40 male BALB/c mice were randomly allocated into four experimental groups (n = 10 per group): a normoglycaemic control, an untreated DN group and two SPX treatment groups (DN+SPX‐12.5 and DN+SPX ...
Mehmet Refik Bahar, Seval Ulku Orhan, Cigdem Tekin, Asli Taslidere, Mete Ozcan, Suat Tekin   +5 more
wiley   +1 more source

Passive Oscillatory Body Motion Attenuates Pain‐Related Behaviors and Increases β‐Endorphin Immunoreactivity in a Murine Fracture Model: A Preliminary Study

Brain and Behavior, Volume 16, Issue 7, July 2026.
ABSTRACT Objective This preliminary study aimed to investigate whether passive oscillatory body motion (PBM), a mechanical stimulus that reproduces vertical accelerations comparable to those generated during treadmill running, could activate the β‐endorphin (β‐END)–related hypothalamus–periaqueductal gray (PAG) pathway and alleviate fracture‐induced ...
Ryoma Kato, Kazuhiro Hayashi, Yuri Okada, Rina Okura, Fuyu Niida, Jun Miyata, Naoyoshi Sakitani, Yasuhiro Sawada, Akira Ito   +8 more
wiley   +1 more source

of induction of persistent nociception by dynorphin [PDF]

, 1996
The opioid peptide dynorphin has been demonstrated to be both nociceptive and antinociceptive. This article will review the potential mechanisms through which dynorphin contributes to spinally mediated nociception.
George L Wilcox, Alice A Larson, Tinna M Laughlin   +2 more
core