Results 71 to 80 of about 11,182 (207)

Opioid Antagonists for Hedonic Liberation—Not All Is Over

Future Pharmacology
Recent Phase 3 clinical trials of selective kappa-opioid (KOP) receptor antagonists aticaprant and navacaprant failed to demonstrate sufficient clinical efficacy in treatment-resistant depression (TRD).
Farid Shagiakhmetov, Inna Shamakina, Viktor Kokhan, Evgeny Krupitsky   +3 more
doaj   +1 more source

Rare but relevant: Ibogaine and cardiovascular complications—prolonged QT interval and ventricular arrhythmias

Addiction, Volume 121, Issue 6, Page 1616-1621, June 2026.
Abstract Revived interest in psychedelic‐assisted therapies has also renewed focus on ibogaine, a psychoactive alkaloid, for its notable anti‐addictive potential. Evidence from observational, open‐label, and limited randomized placebo‐controlled trials indicates that ibogaine and its metabolite noribogaine reduce craving and withdrawal symptoms in ...
Tibor Markus Brunt
wiley   +1 more source

KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone‐independent manner

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.
Nimisha Nandankar, Ariel L. Negrón, Harshini Ganesh, Natalia Youssef, Saad Farooq, Sarmed Al‐Samerria, Jon E. Levine, Sally Radovick   +7 more
wiley   +1 more source

Bulleyaconitine A Inhibits Visceral Nociception and Spinal Synaptic Plasticity through Stimulation of Microglial Release of Dynorphin A

Neural Plasticity, 2020
Background. Visceral pain is one of the most common types of pain and particularly in the abdomen is associated with gastrointestinal diseases. Bulleyaconitine A (BAA), isolated from Aconitum bulleyanum, is prescribed in China to treat chronic pain.
Sheng-Nan Huang, Jinbao Wei, Lan-Ting Huang, Pei-Jun Ju, Jinghong Chen, Yong-Xiang Wang   +5 more
doaj   +1 more source

Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats [PDF]

, 2014
Despite many advances, our understanding of the involvement of prodynorphin systems in the development of neuropathic pain is not fully understood. Recent studies suggest an important role of neuro–glial interactions in the dynorphin effects associated ...
Przewlocka, Barbara, Makuch, Wioletta, Mika, Joanna, Rojewska, Ewelina   +3 more
core   +1 more source

Role of movement in long-term basal ganglia changes: implications for abnormal motor responses

Frontiers in Computational Neuroscience, 2013
Abnormal involuntary movements and dyskinesias elicited by drugs that stimulate dopamine receptors in the basal ganglia are a major issue in the management of Parkinson’s disease (PD).
Nicola eSimola, Micaela eMorelli, Micaela eMorelli, Micaela eMorelli, Giuseppe eFrazzitta, Giuseppe eFrazzitta, Lucia eFrau   +6 more
doaj   +1 more source

Modulatory effects of orexin and dynorphin on stress-related alcohol seeking and relapse: pivotal role of the posterior paraventricular nucleus of the thalamus

Frontiers in Pharmacology
Alcohol use disorder (AUD) remains a significant problem in the United States, resulting in over 178,000 alcohol-related deaths annually. A central problem in treating AUD is the high rate of relapse to alcohol use even after protracted periods of ...
Gabriel Holguin, Rémi Martin-Fardon
doaj   +1 more source

Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit

Cell Reports, 2016
Kappa opioid receptors (KORs) are involved in a variety of aversive behavioral states, including anxiety. To date, a circuit-based mechanism for KOR-driven anxiety has not been described.
Nicole A. Crowley, Daniel W. Bloodgood, J. Andrew Hardaway, Alexis M. Kendra, Jordan G. McCall, Ream Al-Hasani, Nora M. McCall, Waylin Yu, Zachary L. Schools, Michael J. Krashes, Bradford B. Lowell, Jennifer L. Whistler, Michael R. Bruchas, Thomas L. Kash   +13 more
doaj   +1 more source

A Bicyclic Analog of the Linear Peptide Arodyn Is a Potent and Selective Kappa Opioid Receptor Antagonist

Molecules
Kappa opioid receptor (KOR) antagonists have potential therapeutic applications in the treatment of stress-induced relapse to substance abuse and mood disorders.
Solomon A. Gisemba, Michael J. Ferracane, Thomas F. Murray, Jane V. Aldrich   +3 more
doaj   +1 more source

The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective. [PDF]

, 2016
Notable findings point to the significance of the dynorphin peptide neurotransmitter in chronic pain. Spinal dynorphin neuropeptide levels are elevated during development of chronic pain and sustained during persistent chronic pain. Importantly, knockout
Hook, Vivian, Yaksh, Tony, Podvin, Sonia
core   +1 more source