Results 111 to 120 of about 392 (150)
Some of the next articles are maybe not open access.
Dynorphin Convertases and their Functions in CNS
Current Pharmaceutical Design, 2012Neuropeptides play crucial, mediatory roles in many processes that occur in both CNS and PNS. The commonly accepted dogma for the release of bioactive peptides involves cleavage of inactive precursor by sequential action of proteinases recognizing dibasic stretches, followed by truncation of C-terminal Arg/Lys by the carboxypeptidase-like enzyme(s ...
Joanna, Ner, Jerzy, Silberring
openaire +2 more sources
Dynorphin receptor in the blood vessel
Neuropeptides, 1985Using (3H)etorphine, (3H)E, in binding studies, the KD and Bmax for rabbit mesentery and aorta membrane preparations were 0.61 nM and 0.17 fmol/mg tissue respectively, while it was 0.30 nM and 12 fmol/mg tissue in the brain. The IC50 of dynorphin (1-13) (D1-13) for displacing (3H)E binding in the blood vessel was 20 +/- 2.8 nM (S,E,M,), while PLO17, D ...
F Y, Sun, A Z, Zhang
openaire +2 more sources
Antinociceptive profile of dynorphin in the rat
Life Sciences, 1983Morphine, bremazocine, dynorphin(1-17) and two of its fragments (1-13) and (1-8) all increased nociceptive pressure thresholds in the rat after intracerebroventricular administration. Morphine also increased nociceptive heat thresholds in the hotplate test at similar dose-levels. In contrast, bremazocine and the dynorphins were totally inactive against
A G, Hayes, M, Skingle, M B, Tyers
openaire +2 more sources
Dynorphin(1–10)amide: A potent and selective analog of dynorphin(1–13)
Life Sciences, 1982Dynorphin(1-10)amide was more potent than Dynorphin(1-13) in inhibiting the twitch of the mouse vas deferens (IC50 of Dynorphin(1-10)amide = 0.3 nM and IC50 of Dynorphin (1-13) = 4.0 nM). Binding assays indicated that two opioid peptides had similar profiles in that they enhanced dihydromorphine (DHM) binding in picomolar concentrations but displaced ...
S, Woo +5 more
openaire +2 more sources
Neuropeptides, 1984
Multiple forms of Dynorphin A (Dyn A) are present in cardiovascular nuclei in the hypothalamus, along with kappa-opiate receptors. To study the potential role of Dyn A in cardiovascular regulation, various Dyn A species [Dyn A-(1-8; 1-13; 1-17)] were microinjected into the preoptic nucleus (POM) of the anesthetized rat.
G, Feuerstein, A I, Faden
openaire +2 more sources
Multiple forms of Dynorphin A (Dyn A) are present in cardiovascular nuclei in the hypothalamus, along with kappa-opiate receptors. To study the potential role of Dyn A in cardiovascular regulation, various Dyn A species [Dyn A-(1-8; 1-13; 1-17)] were microinjected into the preoptic nucleus (POM) of the anesthetized rat.
G, Feuerstein, A I, Faden
openaire +2 more sources
Dynorphin immunoreactivity in pituitary.
Advances in biochemical psychopharmacology, 1982Tissue ir-dynorphin has been shown to be associated with three components separable by gel filtration. Similar components were found in both pituitary and brain, although there are differences in the relative amounts of each component in each tissue.
B M, Cox, E R, Baer, A, Goldstein
openaire +1 more source
Dynorphins in Development and Disease: Implications for Cardiovascular Disease
Current Molecular Medicine, 2020Jason J Paris, Zia Shariat-Madar
exaly