Results 21 to 30 of about 2,475 (201)

Optogenetic stimulation of dynorphinergic neurons within the dorsal raphe activate kappa opioid receptors in the ventral tegmental area and ablation of dorsal raphe prodynorphin or kappa receptors in dopamine neurons blocks stress potentiation of cocaine reward

Addiction Neuroscience, 2022
Behavioral stress exposure increases the risk of drug-taking in individuals with substance use disorders by mechanisms involving the dynorphins, which are the endogenous neuropeptides for the kappa opioid receptor (KOR).
Antony D. Abraham, Sanne M. Casello, Benjamin B. Land, Charles Chavkin   +3 more
doaj   +1 more source

Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy

Neurobiology of Disease, 2020
Neuropeptides are important signalling molecules in the brain and alterations in their expression levels have been linked to neurological disorders such as Parkinson's disease. It is challenging to map neuropeptide changes across and within brain regions
Heather Hulme, Elva Fridjonsdottir, Halla Gunnarsdottir, Theodosia Vallianatou, Xiaoqun Zhang, Henrik Wadensten, Reza Shariatgorji, Anna Nilsson, Erwan Bezard, Per Svenningsson, Per E. Andrén   +10 more
doaj   +1 more source

The Opioid Peptide Dynorphin a Induces Leukocyte Responses via Integrin Mac-1 (αβ, CD11b/CD18)

Molecular Pain, 2015
Background Opioid peptides, including dynorphin A, besides their analgesic action in the nervous system, exert a broad spectrum of effects on cells of the immune system, including leukocyte migration, degranulation and cytokine production. The mechanisms
Nataly P. Podolnikova, Julie A. Brothwell, Tatiana P. Ugarova   +2 more
doaj   +1 more source

Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway

Cell & Bioscience, 2020
Background Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for mitigating ...
Lin Liu, Yingtong Xu, Hongmei Dai, Shan Tan, Xiao Mao, Zhiheng Chen   +5 more
doaj   +1 more source

Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. [PDF]

PLoS ONE, 2010
BACKGROUND: The opioid system is involved in reward and pain mechanisms and consists in mammals of four receptors and several peptides. The peptides are derived from four prepropeptide genes, PENK, PDYN, PNOC and POMC, encoding enkephalins, dynorphins ...
Görel Sundström, Susanne Dreborg, Dan Larhammar   +2 more
doaj   +1 more source

Salvinorin A, a kappa-opioid receptor (KOP-r) agonist hallucinogen: Pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders

Frontiers in Pharmacology, 2015
Salvinorin A is a potent hallucinogen, isolated from the ethnomedical plant Salvia divinorum. Salvinorin A is a selective high efficacy kappa-opioid receptor (KOPr) agonist, and thus implicates the KOPr system and its endogenous agonist ligands (the ...
Eduardo eButelman, Mary Jeanne eKreek
doaj   +1 more source

Determination of Dynorphins And Tnf- A By Lc-ms/ms In Biological Samples: Applicable To Studying Inflammatory Mechanisms [PDF]

, 2020
Dynorphins are endogenous opioid peptides that have been implicated as initiators ofimmune and inflammatory response through upregulation ofinflammatory cytokine and chemokine production, as well having a role in glutamate-induced neuro-inflammation and ...
Chandu, Karthik
core  

Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies

Frontiers in Pharmacology, 2015
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides (enkephalins, endorphins and dynorphins). The endogenous cannabinoid system comprises lipid neuromodulators (endocannabinoids), enzymes
Katia eBefort
doaj   +1 more source

Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. [PDF]

PLoS ONE, 2014
Dynorphins, endogenous opioid peptides that arise from the precursor protein prodynorphin (Pdyn), are hypothesized to be involved in the regulation of mood states and the neuroplasticity associated with addiction.
Ami Cohen, Timothy W Whitfield, Max Kreifeldt, Pascale Koebel, Brigitte L Kieffer, Candice Contet, Olivier George, George F Koob   +7 more
doaj   +1 more source

Percepción de los nefrólogos españoles sobre un problema antiguo no resuelto: Prurito asociado a la enfermedad renal crónica (Pa-ERC)

Nefrología, 2023
Resumen: Introducción: El prurito asociado a enfermedad renal crónica se define como la sensación desagradable que provoca la necesidad de rascarse en una parte del cuerpo o en todo en personas con enfermedad renal crónica, tras haberse descartado otras
Marian Goicoechea, María Dolores Arenas-Jimenez, Nuria Areste, Rosa Elena Perez-Morales, Vicens Esteve, Emilio Sanchez-Alvarez, Guillermo Alcalde Bezhold, Ana Blanco, Rafael Sanchez-Villanueva, Pablo Molina, Raquel Ojeda, Mario Prieto-Velasco, Juan Manuel Buades   +12 more
doaj   +1 more source