Results 11 to 20 of about 2,342 (192)

Membrane leakage induced by dynorphins

FEBS Letters, 2006
Dynorphins, endogeneous opioid peptides, function as ligands to the opioid kappa receptors and induce non‐opioid excitotoxic effects. Here we show that big dynorphin and dynorphin A, but not dynorphin B, cause leakage effects in large unilamellar phospholipid vesicles (LUVs).
Vladana Vukojević, Georgy Bakalkin, Astrid Gräslund   +2 more
exaly   +4 more sources

Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity [PDF]

Computational and Structural Biotechnology Journal, 2022
Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer’s disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments since they should protect against Aβ ...
Lucía Gallego-Villarejo, Cecilia Wallin, Sylwia Król, Jennifer Enrich-Bengoa, Albert Suades, Marcel Aguilella-Arzo, María José Gomara, Isabel Haro, Sebastian Wärmlander, Francisco J. Muñoz, Astrid Gräslund, Alex Perálvarez-Marín   +11 more
doaj   +2 more sources

Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations [PDF]

Computational and Structural Biotechnology Journal, 2022
Dynorphins are endogenous neuropeptides that function as ligands for the κ-opioid receptor. In addition to opioid activity, dynorphins can induce several pathological effects such as neurological dysfunctions and cell death.
D. Aurora Perini, Marcel Aguilella-Arzo, Antonio Alcaraz, Alex Perálvarez-Marín, María Queralt-Martín   +4 more
doaj   +2 more sources

Cellular Profiles of Prodynorphin and Preproenkephalin mRNA-Expressing Neurons in the Anterior Olfactory Tubercle of Mice [PDF]

Frontiers in Neural Circuits, 2022
The olfactory tubercle (OT) is a striatal region that receives olfactory inputs. mRNAs of prodynorphin (Pdyn) and preproenkephalin (Penk), precursors of dynorphins and enkephalins, respectively, are strongly expressed in the striatum. Both produce opioid
Ayako Maegawa, Ayako Maegawa, Koshi Murata, Koshi Murata, Kazuki Kuroda, Kazuki Kuroda, Shigeharu Fujieda, Yugo Fukazawa, Yugo Fukazawa, Yugo Fukazawa   +9 more
doaj   +2 more sources

Structure–function relationship of dynorphin B variants using naturally occurring amino acid substitutions [PDF]

Frontiers in Pharmacology
Dynorphins (Dyn) represent the subset of endogenous opioid peptides with the highest binding affinity to kappa opioid receptors (KOPrs). Activation of the G-protein-coupled pathway of KOPrs has strong anticonvulsant effects.
Luca Zangrandi, Luca Zangrandi, Barbara Fogli, Anna Mutti, René Staritzbichler, Victoria Most, Peter W. Hildebrand, Peter W. Hildebrand, Regine Heilbronn, Christoph Schwarzer   +9 more
doaj   +2 more sources

Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

Frontiers in Cellular Neuroscience, 2015
The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle.
Daniil eSarkisyan, Muhammad Z. Hussain, Hiroyuki eWatanabe, Olga eKononenko, Olga eKononenko, Igor eBazov, Xing Wu eZhou, Olga eYamskova, Oleg eKrishtal, Victor M. Karpyak, Tatiana eYakovleva, Georgy eBakalkin   +11 more
doaj   +2 more sources

Endogenous Opioids in Crohn’s Disease [PDF]

Biomedicines, 2023
Caring for patients with Crohn’s disease (CD) is a serious challenge in modern medicine. The increasing incidence of CD among adolescents and the severe course of the disease create the need for new methods of diagnosis and therapy.
Adrian Martyniak, Andrzej Wędrychowicz, Przemysław J. Tomasik   +2 more
doaj   +2 more sources

Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia

npj Parkinson's Disease, 2022
L-DOPA administration is the primary treatment for Parkinson’s disease (PD) but long-term administration is usually accompanied by hyperkinetic side-effects called L-DOPA-induced dyskinesia (LID). Signaling neuropeptides of the basal ganglia are affected
Heather Hulme, Elva Fridjonsdottir, Theodosia Vallianatou, Reza Shariatgorji, Anna Nilsson, Qin Li, Erwan Bezard, Per E. Andrén   +7 more
doaj   +2 more sources

Structural basis of divergent substrate recognition and inhibition of human neurolysin [PDF]

Scientific Reports
A zinc metallopeptidase neurolysin (Nln) processes diverse bioactive peptides to regulate signaling in the mammalian nervous system. To understand how Nln interacts with various peptides with dissimilar sequences, we determined crystal structures of Nln ...
Ke Shi, Sounak Bagchi, Jordis Bickel, Shiva H. Esfahani, Lulu Yin, Tiffany Cheng, Vardan T. Karamyan, Hideki Aihara   +7 more
doaj   +2 more sources

Opioid Receptors in Psychedelia: Indirect Serotonergic Modulation of Direct KOR Activation by Salvinorin A [PDF]

Biomedicines
The neuropharmacology of psychedelics has traditionally focused on serotonergic mechanisms, particularly 5-HT2A receptor activation. However, this paradigm incompletely explains the diversity of neurobiological and therapeutic effects observed across ...
Maximiliano Ganado, Carmen Rubio, Javier Pérez-Villavicencio, Norma Serrano, Héctor Romo-Parra, Ángel Lee, Moisés Rubio-Osornio   +6 more
doaj   +2 more sources