Results 11 to 20 of about 2,475 (201)

Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia

npj Parkinson's Disease, 2022
L-DOPA administration is the primary treatment for Parkinson’s disease (PD) but long-term administration is usually accompanied by hyperkinetic side-effects called L-DOPA-induced dyskinesia (LID). Signaling neuropeptides of the basal ganglia are affected
Heather Hulme, Elva Fridjonsdottir, Theodosia Vallianatou, Reza Shariatgorji, Anna Nilsson, Qin Li, Erwan Bezard, Per E. Andrén   +7 more
doaj   +2 more sources

Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics [PDF]

Frontiers in Cellular Neuroscience, 2015
The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle.
Daniil eSarkisyan, Muhammad Z. Hussain, Hiroyuki eWatanabe, Olga eKononenko, Olga eKononenko, Igor eBazov, Xing Wu eZhou, Olga eYamskova, Oleg eKrishtal, Victor M. Karpyak, Tatiana eYakovleva, Georgy eBakalkin   +11 more
doaj   +2 more sources

Involvement of the Opioid Peptide Family in Cancer Progression

Biomedicines, 2023
Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis.
Manuel Lisardo Sánchez, Francisco D. Rodríguez, Rafael Coveñas   +2 more
doaj   +2 more sources

Arcuate kisspeptin neurons display two types of calcium events: Regulation by sex, gonads, and senktide. [PDF]

J Neuroendocrinol
Abstract The pattern of gonadotropin‐releasing hormone (GnRH) release controls reproduction in vertebrates and is regulated by feedback from the gonads. Evidence is accumulating that steroid‐sensitive hypothalamic arcuate kisspeptin–neurokinin B–dynorphin (KNDy) neurons drive GnRH pulses.
DeFazio RA, Burgess CR, Burger LL, Gibson AG, Moenter SM.   +4 more
europepmc   +2 more sources

Dynorphins

, 2013
Janine Sanchez, Kathryn Noth, David G. Marrero, Debra Roter, Brigitte M. Kudielka, Pamela S. King, Yori Gidron, Kimberly Nelson, Ronald Goldberg, Ellen-ge Denton, Sonia Matwin, John Grabowski, Kevin S. Masters, Diane Dixon, Steven Gambert, Daniel Gorrin, Samantha Yard, Annie T. Ginty, Luigi Meneghini, Francine Kaufman, Valerie Sabol, Alefiyah Z. Pishori, Jenny T. Wang, Howard Sollins, Laura Rodriguez-Murillo, Edward L. Perkins, Nina Rieckmann, Rany M. Salem, Joel E. Dimsdale, Lauren Zagorski, Brant P. Hasler, Jason S. Yeh, Marijke Couck, Judith A. Hall, Chad Barrett, William Whang, Joost Dekker, Maartje de Wit, J. Rick Turner, Ana Victoria Soto, C. Andres Bedoya, C. Renn Upchurch Sweeney, Bonnie Levin, Faith S. Luyster, Harry Prapavessis, Beth Schroeder, Monica Dowling, Kathleen Michael, Nicole Brandt, Tamara Goldman Sher, Lara Traeger, Michela Marinelli, Carolyn Korbel, Rachel Flurie, Alvin Jin, Kristen Salomon, Wynne E. Norton, Jennifer Wessel, Tatsuo Akechi   +58 more
core   +3 more sources

The Role of Kappa‐Opioid Receptor/Dynorphin System in Modulating Neural‐Circuits of Depression and Anxiety—A Review [PDF]

J Cell Mol Med
ABSTRACT Major depression and anxiety disorders are psychiatric disorders that involve a great number of people. There is a growing need for new and better pharmacological treatments for these diseases. Kappa‐opioid receptor (KOR) antagonists seem to be a promising new pathway for the development of new antidepressants and anxiolytics, but a great ...
Ciotei C, Păunescu H, Lungu C, Marica A, Tănase M, Marin R, Costescu M, Fulga I, Coman O.   +8 more
europepmc   +2 more sources

Dynorphin, stress, and depression [PDF]

Brain Research, 2010
Stress is most often associated with aversive states. It rapidly induces the release of hormones and neuropeptides including dynorphin, which activates kappa opioid receptors (KORs) in the central and peripheral nervous systems. In animal models, many aversive effects of stress are mimicked or exacerbated by stimulation of KORs in limbic brain regions.
Allison T, Knoll, William A, Carlezon
openaire   +2 more sources

Avian opioid peptides: evolutionary considerations, functional roles and a challenge to address critical questions

Frontiers in Physiology, 2023
The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec, Colin G. Scanes   +1 more
doaj   +1 more source

Endogenous opioid systems alterations in pain and opioid use disorder

Frontiers in Systems Neuroscience, 2022
Decades of research advances have established a central role for endogenous opioid systems in regulating reward processing, mood, motivation, learning and memory, gastrointestinal function, and pain relief.
Jessica A. Higginbotham, Jessica A. Higginbotham, Jessica A. Higginbotham, Tamara Markovic, Nicolas Massaly, Nicolas Massaly, Nicolas Massaly, Jose A. Morón, Jose A. Morón, Jose A. Morón, Jose A. Morón, Jose A. Morón   +11 more
doaj   +1 more source

Endogenous Opioids in Crohn’s Disease

Biomedicines, 2023
Caring for patients with Crohn’s disease (CD) is a serious challenge in modern medicine. The increasing incidence of CD among adolescents and the severe course of the disease create the need for new methods of diagnosis and therapy.
Adrian Martyniak, Andrzej Wędrychowicz, Przemysław J. Tomasik   +2 more
doaj   +1 more source