Results 41 to 50 of about 392 (150)

Altered expression of kisspeptin, dynorphin, and related neuropeptides in polycystic ovary syndrome: A cross-sectional study

International Journal of Reproductive BioMedicine
Background: Since kisspeptin (KISS1) in the hypothalamus is affected by the inhibitory effect of dynorphin, it raises questions about the controlled balance of these 2 neuropeptides in women with and without polycystic ovary syndrome (PCOS).
Andon Hestiantoro, Rachellina Noor Al Maghfira, Ratna Fathmasari, Ririn Rahmala Febri, Ericko Ongko Joyo, Raden Muharam, Gita Pratama, Anom Bowolaksono   +7 more
doaj   +1 more source

Structure–function relationship of dynorphin B variants using naturally occurring amino acid substitutions

Frontiers in Pharmacology
Dynorphins (Dyn) represent the subset of endogenous opioid peptides with the highest binding affinity to kappa opioid receptors (KOPrs). Activation of the G-protein-coupled pathway of KOPrs has strong anticonvulsant effects.
Luca Zangrandi, Luca Zangrandi, Barbara Fogli, Anna Mutti, René Staritzbichler, Victoria Most, Peter W. Hildebrand, Peter W. Hildebrand, Regine Heilbronn, Christoph Schwarzer   +9 more
doaj   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Opioid and non-opioid activities of the dynorphins

, 2005
Endogenous opioid peptides a-neoendorphin, dynorphin A (Dyn A), dynorphin B (Dyn B) and big dynorphin (Big Dyn) consisting of Dyn A and Dyn B, collectively known as dynorphins are derived from the precursor protein prodynorphin (PDYN).
Zoya Marinova (3342749)
core   +1 more source

Repeated Administration of Norbinaltorphimine Produces Cumulative Kappa Opioid Receptor Inactivation

Frontiers in Pharmacology, 2019
Kappa receptor activation by dynorphins contributes to the anxiogenic, dysphoric, and cognitive disrupting effects of repeated stress, suggesting that kappa receptor antagonists might have therapeutic utility in the treatment of stress disorders.
Charles Chavkin, Joshua H. Cohen, Benjamin B. Land   +2 more
doaj   +1 more source

Menopausal hormone therapy and comprehensive postmenopausal care in gynecologic cancer survivors: A position paper from the FIGO Committee on Women at Menopausal Age

International Journal of Gynecology &Obstetrics, Volume 174, Issue 3, Page 1151-1171, September 2026.
Abstract Recent advances in cancer screening, diagnosis, and treatment have greatly improved survival rates among women with gynecologic cancers. More survivors now live long enough to experience treatment‐related menopause. Vasomotor symptoms, genitourinary syndrome of menopause, sexual dysfunction, sleep issues, and long‐term risks from estrogen ...
Agnaldo Lopes da Silva‐Filho, Suvarna Khadilkar, Hema Divakar, Chiara Benedetto, Andrea R. Genazzani, Diana Ramos, Elizabete Argale, Enrique Herrera, Martha Hickey   +8 more
wiley   +1 more source

From dysphoria to depression. The role of dynorphins and kappa opioid receptors in the pathophysiology of stress related disorders [PDF]

, 2013
Stres jest złożonym zjawiskiem, które wywiera wpływ na zdrowie i funkcjonowanie jednostki. Dynorfiny i receptory opioidowe kappa stanowią część endogennego systemu, który kontroluje homeostazę organizmu.
Cieślak, Przemysław
core  

Secondary structure transitions and aggregation induced in dynorphin neuropeptides by the detergent sodium dodecyl sulfate [PDF]

, 2008
Dynorphins, endogeneous opioid neuropeptides, function as ligands to the opioid kappa receptors and also induce non-opioid effects in neurons, probably related to direct membrane interactions. We have characterized the structure transitions of dynorphins
Perálvarez-Marín, Alex,, Barth, Andreas,, Gräslund, Astrid,, Hugonin, Loïc,   +3 more
core   +2 more sources

Corticosteroid Receptor Modulation in the Dorsal Striatum Prevents Morphine‐Induced Place Preference and Reduction in Dopamine Transporter (DAT) Immunoreactivity in Rats

Addiction Biology, Volume 31, Issue 9, September 2026.
Intra‐dorsal striatal corticosterone attenuated morphine‐induced CPP. GR and MR antagonists also attenuated morphine‐induced CPP. Morphine reduced DAT immunoreactivity, an effect prevented by CORT and antagonists. Distinct corticosteroid manipulations converged on similar reward and DAT outcomes.
Payman Raise‐Abdullahi, Fatemeh Rezamohammadi, Mehrnoush Rahmani, Abbas Ali Vafaei, Roghayeh Pakdel, Hamed Rashidipour, Ali Rashidy‐Pour   +6 more
wiley   +1 more source

The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential

Frontiers in Molecular Neuroscience, 2017
Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients often develop cognitive deficits and emotional blunting along the progression of the disease.
Johannes Burtscher, Christoph Schwarzer
doaj   +1 more source