Results 41 to 50 of about 2,475 (201)

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

Prodynorphin Mutations Cause the Neurodegenerative Disorder Spinocerebellar Ataxia Type 23 [PDF]

, 2010
Spinocerebellar ataxias (SCAs) are dominantly inherited neurodegenerative disorders characterized by progressive cerebellar ataxia and dysarthria. We have identified missense mutations in prodynorphin (PDYN) that cause SCA23 in four Dutch families ...
Wijmenga, Cisca, Wijmenga, Cisca; id_orcid, Verschuuren - Bemelmans, Cornelia, Zubarev, Roman A., Cisca Wijmenga, Justyna Jezierska, Roman A. Zubarev, Artemenko, Konstantin A., Hiroyuki Watanabe, Dennis Dooijes, Verbeek, Dineke S., Richard J. Sinke, Knapp, Pamela E., Watanabe, Hiroyuki,, Jezierska, Justyna, Verschuuren-Bemelmans, Corien, Bazov, Igor, Konstantin A. Artemenko, Nyberg, Fred, Bazov, Igor,, Tatjana Yakovleva, Berry Kremer, Van de Warrenburg, Bart P. C., Artemenko, Konstantin A.,, Corien Verschuuren-Bemelmans, Dooijes, Dennis, Dineke S. Verbeek, Kremer, Berry, Bakalkin, Georgy,, Bakalkin, Georgy, Kurt F. Hauser, Igor Bazov, Yakovleva, Tatjana,, Watanabe, Hiroyuki, Cloë Depoorter, Nyberg, Fred,, Sinke, Richard J., Fred Nyberg, Hauser, Kurt F., Yakovleva, Tatjana, Georgy Bakalkin, Bart P.C. Van de Warrenburg, Pamela E. Knapp, Depoorter, C, Van, de Warrenburg BPC, Bakalkin, G, Jezierska, J, Bazov, I, Verschuuren-Bemelmans, C, Watanabe, H, Dooijes, D, Artemenko, KA, Yakovleva, T, Depoorter, Cloe   +53 more
core   +1 more source

Use of Platelet‐Rich Fibrin (PRF) on Palatal Wound Healing: A Narrative Review With Clinical Recommendations

Journal of Periodontal Research, EarlyView.
Based on the available evidence, the application of platelet‐rich fibrin (PRF) following free gingival graft (FGG) and subepithelial connective tissue graft (SCTG) harvesting appears to be a promising approach for enhancing wound healing, minimizing postoperative complications, and reducing analgesic consumption. ABSTRACT This clinical narrative review
Nima Farshidfar, Paras Ahmad, Nathan Estrin, Yufeng Zhang, Richard J. Miron   +4 more
wiley   +1 more source

Dynorphin knockout reduces fat mass and increases weight loss during fasting in mice [PDF]

, 2007
Endogenous opioids, particularly dynorphins, have been implicated in regulation of energy balance, but it is not known how they mediate this in vivo. We investigated energy homeostasis in dynorphin knockout mice (Dyn -/- mice) and probed the interactions
Lee, N, Karl, T, Schwarzer, C, Couzens, M, Boey, D, McNamara, Keely, Slack, Katy, Lin, En-Ju D., Enriquez, Ronaldo, Lee, Nicola J., Herzog, Herbert, McNamara, K, Boey, Dana, Baldock, Paul A., Herzog, H, Sainsbury, Amanda, Lin, EJ, Lin, Shu, Lin, S, Baldock, P, Slack, K, Karl, Tim (R18316), Smythe, George A., Schwarzer, Christoph, Michelle, Couzens, Enriquez, R, Smythe, G   +26 more
core   +1 more source

Microvascular endothelial function is blunted in postmenopausal females with frequent hot flushes

Experimental Physiology, EarlyView.
Abstract Hot flushes of menopause are associated with elevated blood pressure (BP) and diminished macrovascular endothelial function, an initiating factor in the onset of atherosclerosis. Whether microvascular endothelial function is impaired in females with hot flushes, however, remains unknown.
William Stokes, Chowdhury Tasnova Tahsin, Miguel F. Anselmo, Stephany Nathe, Emma J. Lee, Soliana Teshome, Marnie L. Vanden Noven, Anne Blaes, Benjamin W. Langworthy, Manda L. Keller‐Ross   +9 more
wiley   +1 more source

Plasma membrane poration by opioid neuropeptides : a possible mechanism of pathological signal transduction

, 2015
Neuropeptides induce signal transduction across the plasma membrane by acting through cell-surface receptors. The dynorphins, endogenous ligands for opioid receptors, are an exception; they also produce non-receptor-mediated effects causing pain and ...
Krishtal, O., Krishtal, O, Lindskog, C.-J.,, Bakalkin, G.,, Hauser, K. F.,, Lindskog, C-J, Ivanova, T, Krishtal, O.,, Hauser, KF, Bazov, Igor, Bazov, Igor,, Hauser, K. F., Vukojević, V.,, Khmyz, V.,, Maximyuk, O, Khmyz, V., Bakalkin, Georgy,, Bakalkin, Georgy, Ivanova, T.,, Khmyz, V, Bakalkin, G, Ivanova, T., Bazov, I, Maximyuk, O.,, Maximyuk, O., Vukojevic, V., Vukojevic, V,   +26 more
core   +1 more source

Pathobiology of dynorphins in trauma and disease [PDF]

Frontiers in Bioscience, 2005
Dynorphins, endogenous opioid neuropeptides derived from the prodynorphin gene, are involved in a variety of normative physiologic functions including antinociception and neuroendocrine signaling, and may be protective to neurons and oligodendroglia via their opioid receptor-mediated effects. However, under experimental or pathophysiological conditions
Kurt F, Hauser, Jane V, Aldrich, Kevin J, Anderson, Georgy, Bakalkin, MacDonald J, Christie, Edward D, Hall, Pamela E, Knapp, Stephen W, Scheff, Indrapal N, Singh, Bryce, Vissel, Amina S, Woods, Tatiana, Yakovleva, Toni S, Shippenberg   +12 more
openaire   +2 more sources

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Exposure to Cocaine Alters Dynorphin-Mediated Regulation of Excitatory Synaptic Transmission in Nucleus Accumbens Neurons

, 2011
Dysregulation of excitatory synaptic input to nucleus accumbens (NAc) medium spiny neurons (MSNs) underlies a key pathophysiology of drug addiction and addiction-associated emotional and motivational alterations.
Peter A. Neumann, Dong, Yan, Yan Dong, Panksepp, Jaak, Oliver M. Schlüter, Schlüter, Oliver M., Ping Mu, Neumann, Peter A., Jaak Panksepp, Mu, Ping   +9 more
core   +1 more source

Systematic profiling reveals broad G protein coupling and context‐dependent modulation of cyclic AMP by the orphan receptor GPR139

British Journal of Pharmacology, Volume 183, Issue 23, Page 6865-6882, December 2026.
Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov, Hans Bräuner, Alexander Sebastian Hauser   +2 more
wiley   +1 more source