Results 51 to 60 of about 392 (150)

Fertility outcomes and ovarian function recovery after anti‐NMDAR encephalitis: A retrospective cohort study

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 9, Page 1823-1832, September 2026.
Acute hypothalamic–pituitary–ovarian axis suppression is common in anti‐NMDAR encephalitis, yet ovarian function and fertility recover favorably even in teratoma‐associated cases, supporting reassuring long‐term reproductive prognoses. Abstract Introduction Anti‐N‐methyl‐D‐aspartate receptor (anti‐NMDAR) encephalitis predominantly affects women of ...
Jia Wang, Jie Ding, Han Cai, YingXiang Wang, HaoTian Wu   +4 more
wiley   +1 more source

Calcium influx into phospholipid vesicles caused by dynorphin neuropeptides [PDF]

, 2008
Dynorphins, endogeneous opioid peptides, function as ligands to the opioid kappa receptors but also induce non-opioid excitotoxic effects. Dynorphin A can increase the intra-neuronal calcium concentration through a non-opioid and non-NMDA mechanism.
Hugonin, L, Bakalkin, G, Gräslund, Astrid, Gräslund, Astrid,, Hugonin, Loïc, Hugonin, Loïc,, Graslund, A, Vukojević, Vladana, Bakalkin, Georgy,, Bakalkin, Georgy, Vukojevic, V,   +10 more
core   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Effects of Inflammatory Mediators on Gut Sensititvity

Canadian Journal of Gastroenterology, 1999
Over the past decade, attention has been paid to the role of visceral sensitivity in the pathophysiology of functional bowel disorders, especially irritable bowel syndrome, and visceral hypersensitivity is the most widely accepted mechanism responsible ...
Lionel Bueno, Jean Fioramonti
doaj   +1 more source

Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Pulsatile gonadotropin‐releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1ARH neurons via neurokinin B (NKB) signaling through TacR3.
Jian Qiu, Yanyan Lin, Emily Bartram, Janelle M. Tobias, Antonio Muñoz, Xiao Feng Li, Victoria S. Halls, James A. Frank, Martin J. Kelly, Kevin T. O'Byrne   +9 more
wiley   +1 more source

Plasma membrane poration by opioid neuropeptides : a possible mechanism of pathological signal transduction

, 2015
Neuropeptides induce signal transduction across the plasma membrane by acting through cell-surface receptors. The dynorphins, endogenous ligands for opioid receptors, are an exception; they also produce non-receptor-mediated effects causing pain and ...
Krishtal, O., Krishtal, O, Lindskog, C.-J.,, Bakalkin, G.,, Hauser, K. F.,, Lindskog, C-J, Ivanova, T, Krishtal, O.,, Hauser, KF, Bazov, Igor, Bazov, Igor,, Hauser, K. F., Vukojević, V.,, Khmyz, V.,, Maximyuk, O, Khmyz, V., Bakalkin, Georgy,, Bakalkin, Georgy, Ivanova, T.,, Khmyz, V, Bakalkin, G, Ivanova, T., Bazov, I, Maximyuk, O.,, Maximyuk, O., Vukojevic, V., Vukojevic, V,   +26 more
core   +1 more source

A symmetric systemic challenge elicits a right‐biased response mediated by vasopressin signaling

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Water deprivation, a spatially symmetric homeostatic challenge, induces vasopressin receptor‐dependent right‐sided hindlimb asymmetry in rats, providing a binary readout of lateralized physiological regulation. These findings suggest that symmetric homeostatic challenges can engage neuroendocrine mechanisms that shift the balance between left‐ and ...
Hiroyuki Watanabe, Yaromir Kobikov, Sara Yusuf Mohamed, Karen Rich, Daniil Sarkisyan, Olga Nosova, Alfhild Grönbladh, Mathias Hallberg, Jens Schouenborg, Georgy Bakalkin, Mengliang Zhang   +10 more
wiley   +1 more source

Imaging mass spectrometry reveals elevated nigral levels of dynorphin neuropeptides in L-DOPA-induced dyskinesia in rat model of Parkinson's disease.

PLoS ONE, 2011
L-DOPA-induced dyskinesia is a troublesome complication of L-DOPA pharmacotherapy of Parkinson's disease and has been associated with disturbed brain opioid transmission.
Anna Ljungdahl, Jörg Hanrieder, Maria Fälth, Jonas Bergquist, Malin Andersson   +4 more
doaj   +1 more source

Intracerebroventricular injection of neuropeptide Y suppresses luteinizing hormone pulses in mice

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Stress impairs reproduction, at least in part, by inhibition of Kisspeptin/Neurokinin B/Dynorphin (KNDy) cells and suppression of gonadotropin secretion. However, the mechanism for this inhibition is not clear. Neuropeptide Y (NPY) is a pleiotropic molecule that is produced in neurons throughout the brain and mediates several physiological ...
Lauren A. Young, Evan R. Hurtado, Kyla D. Jacobs, Zhi Mei Maria Lee, Casey C Nestor, Richard B. McCosh   +5 more
wiley   +1 more source

Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment

, 2013
The dynorphin opioid peptides control glutamate neurotransmission in the hippocampus. Alcohol-induced dysregulation of this circuit may lead to impairments in spatial learning and memory.
Meis, J.,, Shippenberg, T.,, Kuzmin, A.,, Bakalkin, G.,, Ögren, S. O.,, Bakalkin, Georgy,, Chefer, V.,, Shippenberg, T., Ogren, S. O., Kuzmin, A., Chefer, V., Bazov, Igor,, Meis, J.   +12 more
core   +1 more source