Results 51 to 60 of about 2,475 (201)

From dysphoria to depression. The role of dynorphins and kappa opioid receptors in the pathophysiology of stress related disorders [PDF]

, 2013
Stres jest złożonym zjawiskiem, które wywiera wpływ na zdrowie i funkcjonowanie jednostki. Dynorfiny i receptory opioidowe kappa stanowią część endogennego systemu, który kontroluje homeostazę organizmu.
Cieślak, Przemysław
core  

Distinguishable effects of intrathecal dynorphins, somatostatin, neurotensin and s-calcitonin on nociception and motor function in the rat

, 1988
We determined the effects on nociceptive threshold and motor function of dynorphin-gene products, dynorphin A-(1-32) (DYN A-(1-32), DYN A-(1-8), DYN B and DYN B-29 and the non-opioid peptides somatostatin, neurotensin and salmon calcitonin (s-CT) after ...
Ferri, Sergio, Romualdi, Patrizia, Spampinato, Santi∗, Cavicchini, Emanuela, Candeletti, Sanzio   +4 more
core   +1 more source

Opioid and non-opioid activities of the dynorphins

, 2005
Endogenous opioid peptides a-neoendorphin, dynorphin A (Dyn A), dynorphin B (Dyn B) and big dynorphin (Big Dyn) consisting of Dyn A and Dyn B, collectively known as dynorphins are derived from the precursor protein prodynorphin (PDYN).
Zoya Marinova (3342749)
core   +1 more source

Altered expression of kisspeptin, dynorphin, and related neuropeptides in polycystic ovary syndrome: A cross-sectional study

International Journal of Reproductive BioMedicine
Background: Since kisspeptin (KISS1) in the hypothalamus is affected by the inhibitory effect of dynorphin, it raises questions about the controlled balance of these 2 neuropeptides in women with and without polycystic ovary syndrome (PCOS).
Andon Hestiantoro, Rachellina Noor Al Maghfira, Ratna Fathmasari, Ririn Rahmala Febri, Ericko Ongko Joyo, Raden Muharam, Gita Pratama, Anom Bowolaksono   +7 more
doaj   +1 more source

Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova, Eliska Pritulova, Jiri Novotny   +2 more
wiley   +1 more source

Opioid precursor protein isoform is targeted to the cell nuclei in the human brain [PDF]

, 2017
Background: Neuropeptide precursors are traditionally viewed as proteins giving rise to small neuropeptide molecules. Prodynorphin (PDYN) is the precursor protein to dynorphins, endogenous ligands for the kappa-opioid receptor.
Svenningsen, Åsa Fex,, Yakovleva, Tatiana, Druid, Henrik,, Verbeek, Dineke S,, Rajkowska, Grazyna,, Verbeek, Dineke S., Krishtal, Oleg, Fex Svenningsen, Åsa, Watanabe, Hiroyuki,, Bazov, Igor, Alkass, Kanar, Andersson, Malin,, Bazov, Igor,, Stockmeier, Craig A,, Dyachok, Oleg, Rajkowska, Grazyna, Alkass, Kanar,, Kononenko, Olga,, Andersson, Malin, Bakalkin, Georgy,, Svenningsen, Asa Fex, Bakalkin, Georgy, Watanabe, Hiroyuki, Stockmeier, Craig A, Gerashchenko, Ganna,, Mulder, Jan,, Yakovleva, Tatiana,, Kononenko, Olga, Gerashchenko, Ganna, Yakovleva, Tatjana, Druid, Henrik, Dyachok, Oleg,, Krishtal, Oleg,, Mulder, Jan, Mulder, J,, Verbeek, DS, Watanabe, H, Dyachok, O, Druid, H,, Kononenko, O, Andersson, M, Verbeek, Dineke S, Alkass, K,, Gerashchenko, G, Bazov, I   +44 more
core   +1 more source

Repeated Administration of Norbinaltorphimine Produces Cumulative Kappa Opioid Receptor Inactivation

Frontiers in Pharmacology, 2019
Kappa receptor activation by dynorphins contributes to the anxiogenic, dysphoric, and cognitive disrupting effects of repeated stress, suggesting that kappa receptor antagonists might have therapeutic utility in the treatment of stress disorders.
Charles Chavkin, Joshua H. Cohen, Benjamin B. Land   +2 more
doaj   +1 more source

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Journal of Internal Medicine, Volume 300, Issue 5, Page 590-609, November 2026.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede   +5 more
wiley   +1 more source

The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley   +1 more source

Calcium influx into phospholipid vesicles caused by dynorphin neuropeptides

, 2008
Dynorphins, endogeneous opioid peptides, function as ligands to the opioid kappa receptors but also induce non-opioid excitotoxic effects. Dynorphin A can increase the intra-neuronal calcium concentration through a non-opioid and non-NMDA mechanism.
Hugonin, L, Bakalkin, G, Gräslund, Astrid, Gräslund, Astrid,, Hugonin, Loïc, Hugonin, Loïc,, Graslund, A, Vukojević, Vladana, Bakalkin, Georgy,, Bakalkin, Georgy, Vukojevic, V,   +10 more
core   +1 more source