Results 31 to 40 of about 2,475 (201)

Chapter 15 Nociceptive Behavior Induced by the Endogenous Opioid Peptides Dynorphins in Uninjured Mice

, 2009
Dynorphins, the endogenous opioid peptides derived from prodynorphin may participate not only in the inhibition, but also in facilitation of spinal nociceptive transmission.
Takahashi, Hiroaki,, Shinobu Sakurada, Sakurada, S, Nakagawasai, Osamu,, Nakagawasai, O, Terenius, L,, Tadano, T, Niijima, F, Bakalkin, Georgy,, Takahashi, H, Takeshi Tadano, Terenius, Lars,, Hiroaki Takahashi, Tadano, Takeshi,, Bakalkin, G, Koichi Tan‐No, Fukie Niijima, Tan-No, K, Sakurada, Shinobu,, Niijima, Fukie,, Lars Terenius, Tan-No, Koichi,, Georgy Bakalkin, Osamu Nakagawasai   +23 more
core   +1 more source

Perception of Spanish nephrologists on an old unsolved problem: Pruritus associated with chronic kidney disease (CKD-aP)

Nefrología (English Edition), 2023
Introduction: Pruritus associated with chronic kidney disease is defined as the sensation of itching, in people with chronic kidney disease, in a one area or all over the body that causes the need to scratch, after having ruled out other dermatological ...
Marian Goicoechea, María Dolores Arenas-Jimenez, Nuria Areste, Rosa Elena Perez-Morales, Vicens Esteve, Emilio Sanchez-Alvarez, Guillermo Alcalde Bezhold, Ana Blanco, Rafael Sanchez-Villanueva, Pablo Molina, Raquel Ojeda, Mario Prieto-Velasco, Juan Manuel Buades   +12 more
doaj   +1 more source

Differential Metabolism of Dynorphins in Substantia Nigra, Striatum, and Hippocampus

, 1997
To map the proteolytic enzymes metabolizing dynorphins in brain structures, size-exclusion chromatography linked to electrospray ionization mass spectrometry was used. Enzymes extracted from rat hippocampus, striatum, and substantia nigra were tested for
Koichi Tan-No, Winter, Anders, Sandin, J,, Lubomir Kasakov, Johan Sandin, Jerzy Silberring, Terenius, Lars, TanNo, K, Winter, A, Terenius, L,, Silberring, Jerzy, Silberring, J, Kasakov, Lubomir, Anders Winter, Tan No, Koichi, Kasakov, L, Sandin, Johan, Ingrid Nylander, Nylander, Ingrid,, Nylander, I, Lars Terenius   +20 more
core   +1 more source

Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor

, 2006
The diversity of peptide ligands for a particular receptor may provide a greater dynamic range of functional responses, while maintaining selectivity in receptor activation. Dynorphin A (Dyn A), and dynorphin B (Dyn B) are endogenous opioid peptides that
Bark, N,, Bakalkin, G, Kieffer, BL, Bazov, I, Merg, F, Yakovleva, T, Filliol, D, Usynin, I, Hurd, YL   +8 more
core   +2 more sources

A functional polymorphism in the prodynorphin gene affects cognitive flexibility and brain activation during reversal learning.

Frontiers in Behavioral Neuroscience, 2015
Whether the opioid system plays a role in the ability to flexibly adapt behavior is still unclear. We used fMRI to investigate the effect of a nucleotide tandem repeat (68-bp VNTR) functional polymorphism of the prodynorphin gene on cerebral activation ...
Mikhail eVotinov, Mikhail eVotinov, Jürgen ePripfl, Christian eWindischberger, Ewald eMoser, Uta eSailer, Uta eSailer, Claus eLamm   +7 more
doaj   +1 more source

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Dynorphin‐based “release on demand” gene therapy for drug‐resistant temporal lobe epilepsy

EMBO Molecular Medicine, 2019
Focal epilepsy represents one of the most common chronic CNS diseases. The high incidence of drug resistance, devastating comorbidities, and insufficient responsiveness to surgery pose unmet medical challenges.
Alexandra S Agostinho, Mario Mietzsch, Luca Zangrandi, Iwona Kmiec, Anna Mutti, Larissa Kraus, Pawel Fidzinski, Ulf C Schneider, Martin Holtkamp, Regine Heilbronn, Christoph Schwarzer   +10 more
doaj   +1 more source

Factors Associated With Non‐Vasomotor Menopause Symptoms Experienced by 7285 Women: A UK‐Wide National Survey

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To investigate the factors associated with non‐vasomotor menopause symptoms among women in the UK, focusing on the perceived importance of specific symptoms and their association with demographic and treatment‐related factors. Design A cross‐sectional online survey.
Rhianna Davies, Ashwin Goyal, Zachary Nash, Sarah Hillman, Melanie Davies, Nick Panay, Jane Daniels, Tim Hillard, Bonnie Grant, Paula Briggs, Lynne Robinson, Haitham Hamoda, Channa N. Jayasena   +12 more
wiley   +1 more source

Dynorphin and the pathophysiology of drug addiction [PDF]

Pharmacology & Therapeutics, 2007
Drug addiction is a chronic relapsing disease in which drug administration becomes the primary stimulus that drives behavior regardless of the adverse consequence that may ensue. As drug use becomes more compulsive, motivation for natural rewards that normally drive behavior decreases. The discontinuation of drug use is associated with somatic signs of
T S, Shippenberg, A, Zapata, V I, Chefer
openaire   +2 more sources

Nicotine Effects and the Endogenous Opioid System

Journal of Pharmacological Sciences, 2014
.: Nicotine (NIC) is an exogenous ligand of the nicotinic acetylcholine receptor (nAChR), and it influences various functions in the central nervous system. Systemic administration of NIC elicits the release of endogenous opioids (endorphins, enkephalins,
Shiroh Kishioka, Norikazu Kiguchi, Yuka Kobayashi, Fumihiro Saika   +3 more
doaj   +1 more source