Results 31 to 40 of about 3,745 (209)
Frontiers in Pharmacology, 2015 Salvinorin A is a potent hallucinogen, isolated from the ethnomedical plant Salvia divinorum. Salvinorin A is a selective high efficacy kappa-opioid receptor (KOPr) agonist, and thus implicates the KOPr system and its endogenous agonist ligands (the ...
Eduardo eButelman, Mary Jeanne eKreek
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Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies
Frontiers in Pharmacology, 2015 The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides (enkephalins, endorphins and dynorphins). The endogenous cannabinoid system comprises lipid neuromodulators (endocannabinoids), enzymes
Katia eBefort
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Nefrología, 2023 Resumen: Introducción: El prurito asociado a enfermedad renal crónica se define como la sensación desagradable que provoca la necesidad de rascarse en una parte del cuerpo o en todo en personas con enfermedad renal crónica, tras haberse descartado otras
Marian Goicoechea +12 more
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Acute cocaine treatment increases thimet oligopeptidase in the striatum of rat brain [PDF]
, 2012 Many studies indicate that thimet oligopeptidase (EC3.4.24.15; TOP) can be implicated in the metabolism of bioactive peptides, including dynorphin 1-8, alpha-neoendorphin, beta-neoendorphin and GnRH.
Andersen, Monica Levy +13 more
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Nefrología (English Edition), 2023 Introduction: Pruritus associated with chronic kidney disease is defined as the sensation of itching, in people with chronic kidney disease, in a one area or all over the body that causes the need to scratch, after having ruled out other dermatological ...
Marian Goicoechea +12 more
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THE ROLE OF NEUROTRANSMITTERS IN ALCOHOL DEPENDENCE: ANIMAL RESEARCH [PDF]
, 1996 — Animal studies have demonstrated that alcohol changes neurotransrrutter concentrations in the brain. These changes in levels of dopamine, serotonin, ^aminobutync acid (GABA), endogenous opioid peptides, and noradrcnaline are associated with activation ...
Philippe De Witte
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Dynorphin and the pathophysiology of drug addiction [PDF]
Pharmacology & Therapeutics, 2007 Drug addiction is a chronic relapsing disease in which drug administration becomes the primary stimulus that drives behavior regardless of the adverse consequence that may ensue. As drug use becomes more compulsive, motivation for natural rewards that normally drive behavior decreases. The discontinuation of drug use is associated with somatic signs of
T S, Shippenberg, A, Zapata, V I, Chefer
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Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. [PDF]
PLoS ONE, 2014 Dynorphins, endogenous opioid peptides that arise from the precursor protein prodynorphin (Pdyn), are hypothesized to be involved in the regulation of mood states and the neuroplasticity associated with addiction.
Ami Cohen +7 more
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Frontiers in Behavioral Neuroscience, 2015 Whether the opioid system plays a role in the ability to flexibly adapt behavior is still unclear. We used fMRI to investigate the effect of a nucleotide tandem repeat (68-bp VNTR) functional polymorphism of the prodynorphin gene on cerebral activation ...
Mikhail eVotinov +7 more
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Identification of dynorphin a from zebrafish: A comparative study with mammalian dynorphin A
Neuroscience, 2007 We report the cloning and molecular characterization of the zfPDYN. The complete open reading frame for this propeptide is comprised in two exons that are localized on chromosome 23. zfPDYN cDNA codes for a polypeptide of 252 amino acids that contains the consensus sequences for four opioid peptides: an Ile-enkephalin, the neo-endorphins, dynorphin A ...
González-Nuñez, V. +4 more
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