Results 71 to 80 of about 392 (150)

Exposure to Cocaine Alters Dynorphin-Mediated Regulation of Excitatory Synaptic Transmission in Nucleus Accumbens Neurons

, 2011
Dysregulation of excitatory synaptic input to nucleus accumbens (NAc) medium spiny neurons (MSNs) underlies a key pathophysiology of drug addiction and addiction-associated emotional and motivational alterations.
Peter A. Neumann, Dong, Yan, Yan Dong, Panksepp, Jaak, Oliver M. Schlüter, Schlüter, Oliver M., Ping Mu, Neumann, Peter A., Jaak Panksepp, Mu, Ping   +9 more
core   +1 more source

Dynorphin knockout reduces fat mass and increases weight loss during fasting in mice [PDF]

, 2007
Endogenous opioids, particularly dynorphins, have been implicated in regulation of energy balance, but it is not known how they mediate this in vivo. We investigated energy homeostasis in dynorphin knockout mice (Dyn -/- mice) and probed the interactions
Lee, N, Karl, T, Schwarzer, C, Couzens, M, Boey, D, McNamara, Keely, Slack, Katy, Lin, En-Ju D., Enriquez, Ronaldo, Lee, Nicola J., Herzog, Herbert, McNamara, K, Boey, Dana, Baldock, Paul A., Herzog, H, Sainsbury, Amanda, Lin, EJ, Lin, Shu, Lin, S, Baldock, P, Slack, K, Karl, Tim (R18316), Smythe, George A., Schwarzer, Christoph, Michelle, Couzens, Enriquez, R, Smythe, G   +26 more
core   +1 more source

Presentation_1_Cellular Profiles of Prodynorphin and Preproenkephalin mRNA-Expressing Neurons in the Anterior Olfactory Tubercle of Mice.PDF

, 2022
The olfactory tubercle (OT) is a striatal region that receives olfactory inputs. mRNAs of prodynorphin (Pdyn) and preproenkephalin (Penk), precursors of dynorphins and enkephalins, respectively, are strongly expressed in the striatum. Both produce opioid
Shigeharu Fujieda (188194), Yugo Fukazawa (180184), Koshi Murata (11584171), Ayako Maegawa (13134600), Kazuki Kuroda (3778783)   +4 more
core   +1 more source

Prodynorphin Mutations Cause the Neurodegenerative Disorder Spinocerebellar Ataxia Type 23 [PDF]

, 2010
Spinocerebellar ataxias (SCAs) are dominantly inherited neurodegenerative disorders characterized by progressive cerebellar ataxia and dysarthria. We have identified missense mutations in prodynorphin (PDYN) that cause SCA23 in four Dutch families ...
Depoorter, Cloë, Wijmenga, Cisca, Wijmenga, Cisca; id_orcid, Verschuuren - Bemelmans, Cornelia, Zubarev, Roman A., Cisca Wijmenga, Justyna Jezierska, Roman A. Zubarev, Artemenko, Konstantin A., Hiroyuki Watanabe, Dennis Dooijes, Verbeek, Dineke S., Richard J. Sinke, Knapp, Pamela E., Watanabe, Hiroyuki,, Jezierska, Justyna, Verschuuren-Bemelmans, Corien, Bazov, Igor, Konstantin A. Artemenko, Nyberg, Fred, Bazov, Igor,, Tatjana Yakovleva, Berry Kremer, Van de Warrenburg, Bart P. C., Artemenko, Konstantin A.,, Van de Warrenburg, Bart P.C., Corien Verschuuren-Bemelmans, Dooijes, Dennis, Dineke S. Verbeek, Kremer, Berry, Bakalkin, Georgy,, Bakalkin, Georgy, Kurt F. Hauser, Igor Bazov, Yakovleva, Tatjana,, Watanabe, Hiroyuki, Cloë Depoorter, Nyberg, Fred,, Sinke, Richard J., Fred Nyberg, Hauser, Kurt F., Yakovleva, Tatjana, Georgy Bakalkin, Bart P.C. Van de Warrenburg, Pamela E. Knapp   +44 more
core   +2 more sources

Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor

, 2006
The diversity of peptide ligands for a particular receptor may provide a greater dynamic range of functional responses, while maintaining selectivity in receptor activation. Dynorphin A (Dyn A), and dynorphin B (Dyn B) are endogenous opioid peptides that
Bark, N,, Bakalkin, G, Kieffer, BL, Bazov, I, Merg, F, Yakovleva, T, Filliol, D, Usynin, I, Hurd, YL   +8 more
core   +2 more sources

Opioid Receptors in Psychedelia: Indirect Serotonergic Modulation of Direct KOR Activation by Salvinorin A

Biomedicines
The neuropharmacology of psychedelics has traditionally focused on serotonergic mechanisms, particularly 5-HT2A receptor activation. However, this paradigm incompletely explains the diversity of neurobiological and therapeutic effects observed across ...
Maximiliano Ganado, Carmen Rubio, Javier Pérez-Villavicencio, Norma Serrano, Héctor Romo-Parra, Ángel Lee, Moisés Rubio-Osornio   +6 more
doaj   +1 more source

Prospects for the use of an original medicine based on hexapeptide succinate for organ protection in various diseases

Фармация и фармакология (Пятигорск)
The aim. To analyze and summarize the available results of experimental and clinical scientific studies of synthetic analogs of leu-enkephalin; to evaluate the expansion of the spectrum of application of the original medicine based on hexapeptide ...
Kh. G. Omarova, N. Yu. Pshenichcnaya, A. V. Gorelov, V. S. Shcherbakova, K. Ya. Zaslavskaya, P. A. Bely, A. V. Taganov   +6 more
doaj   +1 more source

Dynorphin: friend or foe?

Pain, 2000
Pain 87 (2000) 235-239. doi:10.1016/S0304-3959(00)00360-2 ; Received by publisher: 2000-05-22 ; Harvest Date: 2016-01-04 12:22:07 ; DOI:10.1016/S0304-3959(00)00360-2 ; Page Range: 235 ...
Department of Oral Surgery, Division of Neuroscience, University of Florida College of Dentistry, P.O. Box 100416, Gainesville, FL 32610, USA ( host institution ), Caudle, Robert M. ( author ), Mannes, Andrew J. ( author )   +2 more
openaire   +3 more sources

Prodynorphin-Derived Opioid Peptides

, 2006
The dynorphin family is composed of multiple peptides. They are distributed in the central nervous system and peripheral tissues. Dynorphins dusply several biological functions, including the regulation of pain transmission, feeding, pituitary hormone ...
SPAMPINATO, SANTI MARIO, SANTI SPAMPINATO   +1 more
core   +1 more source

Mobilization of Specific Neuropeptides by Peripheral Stimulation of Identified Frequencies

, 1992
Three families of endogenous opioid peptides have been characterized in the CNS: enkephalins, endorphins and dynorphins. These can be mobilized by peripheral electrical stimulation.
Q Wang, J-S Han
core   +1 more source