Results 71 to 80 of about 3,745 (209)
Effects of Inflammatory Mediators on Gut Sensititvity
Canadian Journal of Gastroenterology, 1999 Over the past decade, attention has been paid to the role of visceral sensitivity in the pathophysiology of functional bowel disorders, especially irritable bowel syndrome, and visceral hypersensitivity is the most widely accepted mechanism responsible ...
Lionel Bueno, Jean Fioramonti
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 5, May 2026.Excessive exercise induces exercise‐induced fatigue through multiple interconnected mechanisms, including energy shortage and metabolite accumulation, oxidative stress and inflammation, mitochondrial dysfunction, and neuroendocrine strain. Integrative management strategies include nutrition‐based approaches and acupuncture‐based interventions ...
Yaqin Yang +5 more
wiley +1 more source
PLoS ONE, 2011 L-DOPA-induced dyskinesia is a troublesome complication of L-DOPA pharmacotherapy of Parkinson's disease and has been associated with disturbed brain opioid transmission.
Anna Ljungdahl +4 more
doaj +1 more source
A standardized transcutaneous electric acupoint stimulation for relieving tobacco urges in dependent smokers [PDF]
, 2008 The efficacy of acupuncture in smoking cessation, and its effect on the urge to smoke are unclear. We evaluated the effect of a standardized protocol of transcutaneous electric acupoint stimulations (TEAS) on alleviating the urge to smoke.
Berlin, Ivan +6 more
core +1 more source
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders
Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret +5 more
wiley +1 more source
Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment
MedComm, Volume 7, Issue 4, April 2026.Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai +3 more
wiley +1 more source
DREAM Regulates BDNF-Dependent Spinal Sensitization [PDF]
, 2010 Background: The transcriptional repressor DREAM (downstream regulatory element antagonist modulator) controls the expression of prodynorphin and has been involved in the modulation of endogenous responses to pain.
Ivan Rivera-Arconada +9 more
core +1 more source
Understanding cell‐penetrating peptide mechanisms using computational electrophysiology simulations
Protein Science, Volume 35, Issue 4, April 2026.Abstract Cell‐penetrating peptides (CPPs) can enter cells without inducing cytotoxicity and can be coupled with cargo molecules to be used to deliver drugs, DNA, or nanoparticles into cells. The peptide‐membrane interactions driving the internalization mechanism are not completely understood. In this study, we introduce Computational Electrophysiology (
Eric Catalina‐Hernandez +3 more
wiley +1 more source
Effect of Naloxone-3-Glucuronide and N -Methylnaloxone on the Motility of the Isolated Rat Colon After Morphine [PDF]
, 2018 The effect of the opioid antagonists naloxone-3-glucuronide and N-methylnaloxone on rat colon motility after morphine stimulation was measured. The rat model consisted of the isolated, vascularly perfused colon.
Batista, Catarina +5 more
core
Neuronal pathways in tendon healing and tendinopathy : update [PDF]
, 2016 The regulatory mechanisms involved in tendon homeostasis and repair are not fully understood. Accumulating data, however, demonstrate that the nervous system, in addition to afferent (sensory) functions, through efferent neuronal pathways plays an active
Ackermann, Paul +5 more
core +1 more source