Results 81 to 90 of about 2,475 (201)

Lateralized Response of Dynorphin A Peptide Levels after Traumatic Brain Injury

, 2012
Traumatic brain injury (TBI) induces a cascade of primary and secondary events resulting in impairment of neuronal networks that eventually determines clinical outcome.
Watanabe, Hiroyuki,, Knapp, Pamela E., Hussain, Zubair Muhammad,, Hauser, Kurt F., Fitting, Sylvia, Usynin, Ivan, Bakalkin, Georgy,, Scheff, Stephen W., Yakovleva, Tatjana,   +8 more
core   +1 more source

coupling to the rat κ‐opioid receptor

, 1995
We have expressed the cloned rat κ-opioid receptor in human embryonic kidney 293 cells and studied the ability of κ-selective ligands to inhibit adenylyl cyclase. In transfected 293 cells, activation of the κ-opioid receptor by U50,488 and the dynorphins
Yung H. Wong, Satoh, Masamichi, Minami, Masabumi, Masamichi Satoh, Wong, Yung H., Lai, Helen W.L., Helen W.L. Lai, Masabumi Minami   +7 more
core   +1 more source

Dynorphin: friend or foe?

Pain, 2000
Pain 87 (2000) 235-239. doi:10.1016/S0304-3959(00)00360-2 ; Received by publisher: 2000-05-22 ; Harvest Date: 2016-01-04 12:22:07 ; DOI:10.1016/S0304-3959(00)00360-2 ; Page Range: 235 ...
Department of Oral Surgery, Division of Neuroscience, University of Florida College of Dentistry, P.O. Box 100416, Gainesville, FL 32610, USA ( host institution ), Caudle, Robert M. ( author ), Mannes, Andrew J. ( author )   +2 more
openaire   +3 more sources

Prospects for the use of an original medicine based on hexapeptide succinate for organ protection in various diseases

Фармация и фармакология (Пятигорск)
The aim. To analyze and summarize the available results of experimental and clinical scientific studies of synthetic analogs of leu-enkephalin; to evaluate the expansion of the spectrum of application of the original medicine based on hexapeptide ...
Kh. G. Omarova, N. Yu. Pshenichcnaya, A. V. Gorelov, V. S. Shcherbakova, K. Ya. Zaslavskaya, P. A. Bely, A. V. Taganov   +6 more
doaj   +1 more source

Secondary structure transitions and aggregation induced in dynorphin neuropeptides by the detergent sodium dodecyl sulfate

, 2008
Dynorphins, endogeneous opioid neuropeptides, function as ligands to the opioid kappa receptors and also induce non-opioid effects in neurons, probably related to direct membrane interactions. We have characterized the structure transitions of dynorphins
Perálvarez-Marín, Alex,, Barth, Andreas,, Gräslund, Astrid,, Hugonin, Loïc,   +3 more
core  

Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin : differential effects on glia and neurons

, 2007
Dynorphins are endogenous opioid peptide products of the prodynorphin gene. An extensive literature suggests that dynorphins have deleterious effects on CNS injury outcome.
Gharibyan, A.,, Scheff, S. W.,, Hauser, K. F.,, Yakovleva, T.,, Knapp, P. E.,, Bakalkin, Georgy,, Adjan, V. V.,   +6 more
core   +1 more source

Prodynorphin-derived peptides

, 2013
The dynorphin family is composed of multiple peptides generated by posttranslational processing of prodynorphin. They are widely distributed in the central nervous system and occur in peripheral tissues, such as the heart, the gastrointestinal tract, and
SPAMPINATO, SANTI MARIO, BEDINI, ANDREA, Andrea Bedini, Monica Baiula, BAIULA, MONICA, Santi Spampinato   +5 more
core   +1 more source

The endomorphin-1/2 and dynorphin-B peptides display biased agonism at the mu opioid receptor

, 2020
Dynorphins, enkephalins, and endomorphins are endogenous opioid agonist peptides that may possess distinct bias profiles; biased agonism of endogenous peptides could explain the selective roles of these ligands in vivo.
Chiem, Daniel, LaVigne, Justin, Keresztes, Attila, Streicher, John M   +3 more
core   +1 more source

Characterization of the opioid receptor type mediating inhibition of rat gastric somatostatin secretion

, 1990
The opioid peptides are potent inhibitors of gastric somatostatin-like immunoreactivity (SLI) secretion from the isolated perfused rat stomach. In addition, inhibition of SLI secretion induced by vagal stimulation is partially blocked by naloxone ...
C. H. McIntosh, Y. N. Kowk, X. Jia
core   +1 more source

AGING AND THE DYNORPHINERGIC SYSTEM: EVALUATION OF MEMORY AND MOTOR SYSTEMS IN PRODYNORPHIN KNOCKOUT MICE [PDF]

, 2007
Dynorphins, endogenous peptide neurotransmitters expressed in the central nervous system, have been implicated in diverse pathophysiological processes, including excitotoxicity, chronic inflammation, traumatic injury, cognitive impairment, and motor ...
Nguyen, Xuan V.
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