Results 61 to 70 of about 392 (150)
Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.Abstract INTRODUCTION Neural network and bioenergetic abnormalities occur with Alzheimer's disease (AD) pathogenesis. METHODS We explored mossy fiber (MF) and mitoenergetic alteration using ɑ‐smooth muscle actin (ɑSMA) and cytochrome c oxidase (COX) immunolabeling in human hippocampus relative to tangle and plaque formation by referring to Braak (0–VI)
Tian Tu +11 more
wiley +1 more source
Structural basis of divergent substrate recognition and inhibition of human neurolysin
Scientific ReportsA zinc metallopeptidase neurolysin (Nln) processes diverse bioactive peptides to regulate signaling in the mammalian nervous system. To understand how Nln interacts with various peptides with dissimilar sequences, we determined crystal structures of Nln ...
Ke Shi +7 more
doaj +1 more source
Role of PBN‐CeA Circuit in Paclitaxel‐Induced Neuropathic Pain and Negative Emotions
CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.Paclitaxel‐induced neuropathy recruits the PBN–CeA pathway and increases CeA PDYN expression, contributing to pain hypersensitivity and negative emotional behaviors. Suppressing PBN inputs to the CeA or blocking KOR with Navacaprant mitigates both sensory hypersensitivity and negative emotional symptoms.
Huiqin Chen +9 more
wiley +1 more source
, 2013 The endogenous opioid system (EOS) plays a critical role in addictive processes. Molecular dysregulations in this system may be specific for different stages of addiction cycle and neurocircuitries involved and therefore may differentially contribute to ...
Sarkisyan, Daniil, +21 more
core +1 more source
Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)
Phytotherapy Research, Volume 40, Issue 8, Page 4880-4897, August 2026.ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley +1 more source
Role of Opioid Ligands in the Irritable Bowel Syndrome
Canadian Journal of Gastroenterology, 1999 Endogenous opioid peptides – enkephalins, beta-endorphin and dynorphins – are located in specific sites of the brain, the spinal cord, the autonomic ganglia and the enteric nervous system.
Enrico Corazziari
doaj +1 more source
Therapeutic potential of spexin in diabetic neuropathy: Insights from in vitro and in vivo models
Experimental Physiology, Volume 111, Issue 8, Page 3800-3817, 1 August 2026.Abstract The present study investigated the therapeutic potential of spexin (SPX) on both in vitro and in vivo models of diabetic neuropathy (DN). A total of 40 male BALB/c mice were randomly allocated into four experimental groups (n = 10 per group): a normoglycaemic control, an untreated DN group and two SPX treatment groups (DN+SPX‐12.5 and DN+SPX ...
Mehmet Refik Bahar +5 more
wiley +1 more source
, 1988 Antibodies to methionine enkephalin and to dynorphin B were used in an immunocytochemical study examining co-containment of enkephalins and dynorphins in olivocochlear neurons in the guinea pig lateral superior olive.
J Fex +3 more
core +1 more source
Opioid and non-opioid activities of the dynorphins [Elektronisk resurs]
, 2005 Endogenous opioid peptides a-neoendorphin, dynorphin A (Dyn A), dynorphin B (Dyn B) and big dynorphin (Big Dyn) consisting of Dyn A and Dyn B, collectively known as dynorphins are derived from the precursor protein prodynorphin (PDYN).
Marinova, Z,
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