Results 61 to 70 of about 2,342 (192)

Determination of Dynorphins And Tnf- A By Lc-ms/ms In Biological Samples: Applicable To Studying Inflammatory Mechanisms

, 2020
Dynorphins are endogenous opioid peptides that have been implicated as initiators ofimmune and inflammatory response through upregulation ofinflammatory cytokine and chemokine production, as well having a role in glutamate-induced neuro-inflammation and ...
Chandu, Karthik
core   +1 more source

Plasma membrane poration by opioid neuropeptides : a possible mechanism of pathological signal transduction

, 2015
Neuropeptides induce signal transduction across the plasma membrane by acting through cell-surface receptors. The dynorphins, endogenous ligands for opioid receptors, are an exception; they also produce non-receptor-mediated effects causing pain and ...
Krishtal, O., Krishtal, O, Lindskog, C.-J.,, Bakalkin, G.,, Hauser, K. F.,, Lindskog, C-J, Ivanova, T, Krishtal, O.,, Hauser, KF, Bazov, Igor, Bazov, Igor,, Hauser, K. F., Vukojević, V.,, Khmyz, V.,, Maximyuk, O, Khmyz, V., Bakalkin, Georgy,, Bakalkin, Georgy, Ivanova, T.,, Khmyz, V, Bakalkin, G, Ivanova, T., Bazov, I, Maximyuk, O.,, Maximyuk, O., Vukojevic, V., Vukojevic, V,   +26 more
core   +1 more source

The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential

Frontiers in Molecular Neuroscience, 2017
Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients often develop cognitive deficits and emotional blunting along the progression of the disease.
Johannes Burtscher, Christoph Schwarzer
doaj   +1 more source

Vascular health and exercise in females throughout the lifespan: Exploring puberty, pregnancy and menopause

Experimental Physiology, Volume 111, Issue 6, Page 2840-2859, 1 June 2026.
Abstract This narrative review highlights the impact of exercise on vascular health in females over the lifespan with an emphasis on puberty, pregnancy and menopause. These events encompass substantial changes in sex hormone levels, particularly oestrogens and progesterone.
Kathleen B. Miller, M. Erin Moir, Brandon G. Fico   +2 more
wiley   +1 more source

Effects of Inflammatory Mediators on Gut Sensititvity

Canadian Journal of Gastroenterology, 1999
Over the past decade, attention has been paid to the role of visceral sensitivity in the pathophysiology of functional bowel disorders, especially irritable bowel syndrome, and visceral hypersensitivity is the most widely accepted mechanism responsible ...
Lionel Bueno, Jean Fioramonti
doaj   +1 more source

Oxytocin‐ und Vasopressin‐Photosonden zur Entschlüsselung der Neuropeptid‐Signalgebung mit hoher räumlicher und zeitlicher Präzision

Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.
Neue biokompatible Oxytocin‐ und Vasopressin‐Photosonden mit modernsten Photocages. Diese Photosonden sind inaktiv und können mit spezifischen Lichtwellen entschützt werden, was eine Rezeptoraktivierung mit hoher zeitlicher und räumlicher Kontrolle ermöglicht. Abbildung erstellt mit https://BioRender.com ZUSAMMENFASSUNG Das Oxytocin/Vasopressin (OT/VP)
Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler   +7 more
wiley   +1 more source

Imaging mass spectrometry reveals elevated nigral levels of dynorphin neuropeptides in L-DOPA-induced dyskinesia in rat model of Parkinson's disease.

PLoS ONE, 2011
L-DOPA-induced dyskinesia is a troublesome complication of L-DOPA pharmacotherapy of Parkinson's disease and has been associated with disturbed brain opioid transmission.
Anna Ljungdahl, Jörg Hanrieder, Maria Fälth, Jonas Bergquist, Malin Andersson   +4 more
doaj   +1 more source

Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution

Angewandte Chemie International Edition, Volume 65, Issue 22, 25 May 2026.
Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler   +7 more
wiley   +1 more source

Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment

, 2013
The dynorphin opioid peptides control glutamate neurotransmission in the hippocampus. Alcohol-induced dysregulation of this circuit may lead to impairments in spatial learning and memory.
Meis, J.,, Shippenberg, T.,, Kuzmin, A.,, Bakalkin, G.,, Ögren, S. O.,, Bakalkin, Georgy,, Chefer, V.,, Shippenberg, T., Ogren, S. O., Kuzmin, A., Chefer, V., Bazov, Igor,, Meis, J.   +12 more
core   +1 more source

The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction

, 2013
The endogenous opioid system (EOS) plays a critical role in addictive processes. Molecular dysregulations in this system may be specific for different stages of addiction cycle and neurocircuitries involved and therefore may differentially contribute to ...
Sarkisyan, Daniil,, Kononenko, Olga,, Hussain, Muhammad Z., Sarkisyan, Daniil, Kuntić, Vesna, Taqi, Malik M., Bakalkin, Georgy,, Taqi, Malik M.,, Bakalkin, Georgy, Yakovleva, Tatjana,, Watanabe, Hiroyuki,, Hussain, Muhammad Zubair,, Watanabe, Hiroyuki, Nyberg, Fred,, Bazov, Igor, Hussain, Muhammad Z.,, Nyberg, Fred, Kuntić, Vesna,, Bazov, Igor,, Taqi, Malik Mumtaz,, Kononenko, Olga, Yakovleva, Tatjana   +21 more
core   +1 more source