Results 81 to 90 of about 10,432 (275)
Alanine scan of the opioid peptide dynorphin B amide [PDF]
, 2018 To date structure-activity relationship (SAR) studies of the dynorphins (Dyn), endogenous peptides for kappa opioid receptors (KOR), have focused almost exclusively on Dyn A with minimal studies on Dyn B.
Aldrich, Jane V. +2 more
core +1 more source
Role of Opioid Ligands in the Irritable Bowel Syndrome
Canadian Journal of Gastroenterology, 1999 Endogenous opioid peptides – enkephalins, beta-endorphin and dynorphins – are located in specific sites of the brain, the spinal cord, the autonomic ganglia and the enteric nervous system.
Enrico Corazziari
doaj +1 more source
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
Acupuncture's Effects in Treating the Sequelae of Acute and Chronic Spinal Cord Injuries: A Review of Allopathic and Traditional Chinese Medicine Literature [PDF]
, 2011 Each year, there are an estimated 12 000 individuals who sustain a spinal cord injury (SCI) in the United States. Improved understanding of the pathophysiology of SCI and its sequelae has over the past 50 years led to the development of medical ...
Dorsher, Peter T., McIntosh, Peter M.
core +3 more sources
Neurobiology of Disease, 2020 Neuropeptides are important signalling molecules in the brain and alterations in their expression levels have been linked to neurological disorders such as Parkinson's disease. It is challenging to map neuropeptide changes across and within brain regions
Heather Hulme +10 more
doaj
The FASEB Journal, Volume 39, Issue 12, 30 June 2025.In adult Gw female mice, competition between transgenic and endogenous Gata4 promoters leads to decreased Gata4 expression in the hypothalamus while it remains unaffected in the ovaries. The resulting PCOS‐like traits, combining reproductive and metabolic dysfunctions in these mice, support a central (CNS)—not peripheral (ovarian)—mechanism of disease ...
Sherin A. Nawaito +16 more
wiley +1 more source
GZ coupling to the rat κ-opioid receptor [PDF]
, 1995 We have expressed the cloned rat κ-opioid receptor in human embryonic kidney 293 cells and studied the ability of κ-selective ligands to inhibit adenylyl cyclase. In transfected 293 cells, activation of the κ-opioid receptor by U50,488 and the dynorphins
Lai, Helen W.L. +3 more
core +1 more source
The Nasal–Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases
MedComm, Volume 6, Issue 6, June 2025.Τhe BBB restricts CNS drug delivery. NBDD bypasses the BBB via olfactory/trigeminal routes, enabling CNS delivery of therapeutic (small molecules, biologics, nucleic acids) for neurodegenerative/psychiatric disorders and brain tumors using advanced NBDD delivery systems (e.g nanocarriers) to enhance targeting and bioavailability.
Yi Qiu +7 more
wiley +1 more source
An opioid-like system regulating feeding behavior in C. elegans [PDF]
, 2015 Neuropeptides are essential for the regulation of appetite. Here we show that neuropeptides could regulate feeding in mutants that lack neurotransmission from the motor neurons that stimulate feeding muscles. We identified nlp-24 by an RNAi screen of 115
Artyukhin, Alexander B. +3 more
core +3 more sources