Concentration–QTc Modeling to Support Clinical Development of Fezolinetant
Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.Abstract Fezolinetant is a non‐hormonal, selective neurokinin‐3 receptor antagonist that blocks neurokinin B activation of kisspeptin/neurokinin B/dynorphin neurons to thereby modulate neuronal activity in the thermoregulatory center. Fezolinetant has been approved in many regions, including North America, Europe, Asia, and Australia for the treatment ...
Jace C. Nielsen +6 more
wiley +1 more source
Effect of Naloxone-3-Glucuronide and N -Methylnaloxone on the Motility of the Isolated Rat Colon After Morphine [PDF]
, 2018 The effect of the opioid antagonists naloxone-3-glucuronide and N-methylnaloxone on rat colon motility after morphine stimulation was measured. The rat model consisted of the isolated, vascularly perfused colon.
Batista, Catarina +5 more
core
Kinin B(1) receptor deficiency leads to leptin hypersensitivity and resistance to obesity [PDF]
, 2008 OBJECTIVE-Kinins mediate pathophysiological processes related to hypertension, pain, and inflammation through the activation of two G-protein-coupled receptors, named B(1) and B(2).
Araujo, Ronaldo de Carvalho +19 more
core +3 more sources
Interoceptive Information of Physical Vigor Through Circulating Insulin‐Like Growth Factor 1
FASEB BioAdvances, Volume 8, Issue 1, January 2026.Schematic representation of the relationships between circulating IGF‐1, orexin, and VTA neurons to promote physical activity. After physical activity is increased in response to internal or external stimuli, entrance of circulating IGF‐1 into the brain is enhanced (1).
Jonathan A. Zegarra‐Valdivia +6 more
wiley +1 more source
Receptors of peptides as therapeutic targets in epilepsy research [PDF]
, 2014 Neuropeptides are signaling molecules participating in the modulation of synaptic transmission. Neuropeptides are stored in dense core synaptic vesicles, the release of which requires profound excitation.
Dobolyi, A. +5 more
core +1 more source
Food and the brain: Neural and endocrine control of feeding, metabolism, and reproduction
Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.Abstract Feeding and reproductive function are regulated by intricate systems that monitor food availability and energy stores, and on the basis of energy status, promote or put a brake on reproduction. This is particularly evident in the systems that regulate feeding and reproductive state in female mammals.
Naira da Silva Mansano +2 more
wiley +1 more source
A Theory of Natural Addiction [PDF]
Economic theories of rational addiction aim to describe consumer behavior in the presence of habit-forming goods. We provide a biological foundation for this body of work by formally specifying conditions under which it is optimal to form a habit.
Attila Tasnádi, Trenton G. Smith
core +3 more sources
Hippocampus: Why is it studied so frequently? [PDF]
, 2014 nem
Aksić Milan +6 more
core +1 more source
Implicaciones de la introducción del Nalmefeno en el tratamiento de la dependencia alcohólica en España [PDF]
, 2014 Nalmefeno es el primer tratamiento aprobado por la Unión Europea para reducir el consumo de alcohol en dependientes del alcohol con consumo de riesgo prescrito en el contexto de un abordaje motivacional.
Rubio Valladolid, Gabriel
core
Hippocampal neuroplasticity induced by early-life stress: functional and molecular aspects. [PDF]
, 2006 Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role
Baram, Tallie Z +2 more
core +1 more source