E‐cadherin deregulation in breast cancer [PDF]
Journal of Cellular and Molecular Medicine, 2020 AbstractE‐cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E‐cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene
Corso G. +14 more
openaire +5 more sources
E-cadherin in contact inhibition and cancer [PDF]
Oncogene, 2018 E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence.
Mendonsa, Alisha +2 more
openaire +3 more sources
E-cadherin: A determinant molecule associated with ovarian cancer progression, dissemination and aggressiveness. [PDF]
PLoS ONE, 2017 Ovarian cancer (OC) is the fifth cancer death cause in women worldwide. The malignant nature of this disease stems from its unique dissemination pattern.
Marina Rosso +16 more
doaj +2 more sources
pVHL status in clear cell renal cell carcinoma regulates HIF-α and E-cadherin expression levels and their implications for tumor progression [PDF]
Upsala Journal of Medical SciencesObjectives: This study aimed to determine the effects of von Hippel–Lindau protein (VHL) expression on hypoxia-inducible factor (HIF) and E-cadherin proteins.
Raviprakash T. Sitaram, Börje Ljungberg
doaj +2 more sources
Expression Patterns of E-Cadherin and N-Cadherin Proteins in the Periodontal Pocket Epithelium of Chronic Periodontitis [PDF]
Journal of Dentistry, 2023 Statement of the Problem: E-cadherin and N-cadherin are two types of cell adhesion molecules that are involved in organ development, wound healing, and pathological conditions through the process of epithelial-mesenchymal transition (EMT). However, their
Hamideh Kadeh +2 more
doaj +1 more source
Biomolecules, 2022 E-cadherin is a key regulator of epithelial cell–cell adhesion, the loss of which accelerates tumor growth and invasion. E-cadherin is also expressed in hematopoietic cells as well as epithelia.
Rosa A. Krimpenfort +6 more
doaj +1 more source
Clinical Epidemiology and Global Health, 2023 Objectives: Endometrial carcinoma (EC), majority being endometroid endometrial carcinoma (EEC), is the most common invasive gynecological cancer world-wide.
Sunita Yadav +5 more
doaj +1 more source
E-cadherin can replace N-cadherin during secretory-stage enamel development. [PDF]
PLoS ONE, 2014 N-cadherin is a cell-cell adhesion molecule and deletion of N-cadherin in mice is embryonic lethal. During the secretory stage of enamel development, E-cadherin is down-regulated and N-cadherin is specifically up-regulated in ameloblasts when groups of ...
Xiaomu Guan +3 more
doaj +1 more source
The Scribble polarity protein stabilizes E-cadherin/p120-catenin binding and blocks retrieval of E-cadherin to the Golgi. [PDF]
PLoS ONE, 2012 Several polarity proteins, including Scribble (Scrb) have been implicated in control of vesicle traffic, and in particular the endocytosis of E-cadherin, but through unknown mechanisms.
Madhura Lohia, Yi Qin, Ian G Macara
doaj +1 more source
Reversible photoregulation of cell-cell adhesions with opto-E-cadherin
Nature Communications, 2023 E-cadherin-based cell-cell adhesions are dynamically and locally regulated in many essential processes, including embryogenesis, wound healing and tissue organization, with dysregulation manifesting as tumorigenesis and metastasis.
Brice Nzigou Mombo +7 more
doaj +1 more source