Results 1 to 10 of about 164,060 (248)

pVHL status in clear cell renal cell carcinoma regulates HIF-α and E-cadherin expression levels and their implications for tumor progression [PDF]

Upsala Journal of Medical Sciences
Objectives: This study aimed to determine the effects of von Hippel–Lindau protein (VHL) expression on hypoxia-inducible factor (HIF) and E-cadherin proteins.
Raviprakash T. Sitaram, Börje Ljungberg
doaj   +2 more sources

Expression Patterns of E-Cadherin and N-Cadherin Proteins in the Periodontal Pocket Epithelium of Chronic Periodontitis [PDF]

Journal of Dentistry, 2023
Statement of the Problem: E-cadherin and N-cadherin are two types of cell adhesion molecules that are involved in organ development, wound healing, and pathological conditions through the process of epithelial-mesenchymal transition (EMT). However, their
Hamideh Kadeh, Fereshteh Arbabi-Kalati, Mahdi Ramezaninejad   +2 more
doaj   +1 more source

E-Cadherin Expression Distinguishes Mouse from Human Hematopoiesis in the Basophil and Erythroid Lineages

Biomolecules, 2022
E-cadherin is a key regulator of epithelial cell–cell adhesion, the loss of which accelerates tumor growth and invasion. E-cadherin is also expressed in hematopoietic cells as well as epithelia.
Rosa A. Krimpenfort, Felix M. Behr, Marja Nieuwland, Iris de Rink, Ron Kerkhoven, Marieke von Lindern, Micha Nethe   +6 more
doaj   +1 more source

Immunohistochemical expression of E-cadherin and N-cadherin in endometrioid endometrial carcinoma and its precursor lesions

Clinical Epidemiology and Global Health, 2023
Objectives: Endometrial carcinoma (EC), majority being endometroid endometrial carcinoma (EEC), is the most common invasive gynecological cancer world-wide.
Sunita Yadav, Annu Makkar, Preeti Agarwal, Uma Singh, Uma Shankar Singh, Madhu Mati Goel   +5 more
doaj   +1 more source

The Scribble polarity protein stabilizes E-cadherin/p120-catenin binding and blocks retrieval of E-cadherin to the Golgi. [PDF]

PLoS ONE, 2012
Several polarity proteins, including Scribble (Scrb) have been implicated in control of vesicle traffic, and in particular the endocytosis of E-cadherin, but through unknown mechanisms.
Madhura Lohia, Yi Qin, Ian G Macara
doaj   +1 more source

E‐cadherin deregulation in breast cancer [PDF]

Journal of Cellular and Molecular Medicine, 2020
AbstractE‐cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E‐cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene
Corso G., Figueiredo J., De Angelis S. P., Corso F., Girardi A., Pereira J., Seruca R., Bonanni B., Carneiro P., Pravettoni G., Guerini Rocco E., Veronesi P., Montagna G., Sacchini V., Gandini S.   +14 more
openaire   +4 more sources

Reversible photoregulation of cell-cell adhesions with opto-E-cadherin

Nature Communications, 2023
E-cadherin-based cell-cell adhesions are dynamically and locally regulated in many essential processes, including embryogenesis, wound healing and tissue organization, with dysregulation manifesting as tumorigenesis and metastasis.
Brice Nzigou Mombo, Brent M. Bijonowski, Christopher A. Raab, Stephan Niland, Katrin Brockhaus, Marc Müller, Johannes A. Eble, Seraphine V. Wegner   +7 more
doaj   +1 more source

Association of quantitative analysis of intratumoral reduced E-cadherin expression with lymph node metastasis and prognosis in patients with breast cancer

Scientific Reports, 2023
Loss of E-cadherin expression is a poor prognostic factor in patients with breast cancer. Breast cancer cells co-cultured with adipocytes reportedly promote E-cadherin attenuation and tumor progression.
Xiangyue Meng, Michi Morita, Sayaka Kuba, Hiroko Hayashi, Ryota Otsubo, Megumi Matsumoto, Kosho Yamanouchi, Kazuma Kobayashi, Akihiko Soyama, Masaaki Hidaka, Kengo Kanetaka, Takeshi Nagayasu, Susumu Eguchi   +12 more
doaj   +1 more source

CD148 tyrosine phosphatase promotes cadherin cell adhesion. [PDF]

PLoS ONE, 2014
CD148 is a transmembrane tyrosine phosphatase that is expressed at cell junctions. Recent studies have shown that CD148 associates with the cadherin/catenin complex and p120 catenin (p120) may serve as a substrate.
Keiko Takahashi, Anton Matafonov, Katherine Sumarriva, Hideyuki Ito, Colette Lauhan, Dana Zemel, Nobuo Tsuboi, Jin Chen, Albert Reynolds, Takamune Takahashi   +9 more
doaj   +1 more source

E-Cadherin Orthologues as Substrates for the Serine Protease High Temperature Requirement A (HtrA)

Biomolecules, 2022
Helicobacter pylori (H. pylori) expresses the serine protease and chaperone High temperature requirement A (HtrA) that is involved in periplasmic unfolded protein stress response. Additionally, H.
Sabine Bernegger, Evelyn Hutterer, Urszula Zarzecka, Thomas P. Schmidt, Markus Huemer, Isabella Widlroither, Gernot Posselt, Joanna Skorko-Glonek, Silja Wessler   +8 more
doaj   +1 more source