Results 71 to 80 of about 23,495 (266)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Educación y Educadores, 2012 Este artículo presenta la implementación de los sistemas cognitivos artificiales (SCA) en los procesos de enseñanza-aprendizaje de las matemáticas. La justificación teórica de tal implementación se hace desde el punto de vista de la Matemática y la ...
Luis Alberto Toro-Carvajal +3 more
doaj
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Sliding mode control for a nonlinear phase-field system
, 2017 In the present contribution the sliding mode control (SMC) problem for a phase-field model of Caginalp type is considered. First we prove the well-posedness and some regularity results for the phase-field type state systems modified by the state-feedback
Barbu, Viorel +4 more
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Memória Operacional na aprendizagem Matemática: mapeamento teórico de produções brasileiras
Boletim GEPEM, 2018 Neste artigo apresenta-se um mapeamento teórico de publicações brasileiras com o enfoque na Memória Operacional e suas implicações na Aprendizagem Matemática, com o objetivo de identificar possíveis confluências nas produções selecionadas, comparando ...
Bruna Dorneles Silveira +1 more
doaj +3 more sources
A FORMAÇÃO MATEMÁTICA NO CURSO DE PEDAGOGIA: aprendizagens a partir da modelagem matemática
Cadernos de Pesquisa, 2018 A investigação apresentada, situada no campo da Modelagem Matemática na perspectiva da Educação Matemática, é resultado de um curso desenvolvido com acadêmicos de Pedagogia da Universidade Estadual do Centro-Oeste do Paraná, UNICENTRO.
Vantielen da Silva Silva +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Construction of embedded fMRI resting state functional connectivity networks using manifold learning
, 2020 We construct embedded functional connectivity networks (FCN) from benchmark resting-state functional magnetic resonance imaging (rsfMRI) data acquired from patients with schizophrenia and healthy controls based on linear and nonlinear manifold learning ...
Galaris, Evangelos +2 more
core
, 2019 Restricted Boltzmann machines (RBMs) constitute one of the main models for machine statistical inference and they are widely employed in Artificial Intelligence as powerful tools for (deep) learning.
Agliari, Elena +2 more
core +1 more source