Results 61 to 70 of about 379 (179)
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Cultura da educação matemática nas tirinhas “Calvin e Haroldo”
e-Hum: Revista das Áreas de Humanidade do Centro Universitário de Belo Horizonte, 2009 eoi/doi Deposit-Electronic Object Identifier http://eoi.citefactor.org/10.11248/ehum.v2i2.402 RESUMO: o artigo discute os elementos da cultura da educação matemática presentes nas tirinhas Calvin e Haroldo, do cartunista americano Bill Watterson,
Davi Mourão Motta Drummond +1 more
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Zetetiké, 2009 O objetivo do estudo foi identificar as percepções dos professores em relação ao seu próprio desenvolvimento. Isto é, percepções de mudanças que ocorreram em seu pensamento e/ou prática através dos anos e suas percepções de que tipo de experiências ou ...
Altair F. F. Polettini
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Blended learning in un corso universitario di matematica
Italian Journal of Educational Technology, 2011 Note sull’uso di una piattaforma per e-learning come supporto alla didattica tradizionale.
Margherita D'Aprile
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Memória Operacional na aprendizagem Matemática: mapeamento teórico de produções brasileiras
Boletim GEPEM, 2018 Neste artigo apresenta-se um mapeamento teórico de publicações brasileiras com o enfoque na Memória Operacional e suas implicações na Aprendizagem Matemática, com o objetivo de identificar possíveis confluências nas produções selecionadas, comparando ...
Bruna Dorneles Silveira +1 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source