Results 71 to 80 of about 3,162,158 (317)

The IDB: Vol. 23, no. 1-2, January-February, 1996

open access: yes, 1996
O BID acompanha o desenvolvimento econmico e social da América Latina e do Caribe, assim como as atividades do Banco.
Inter-American Development Bank
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

The IDB: Vol. 23, no. 7, July 1996

open access: yes, 1996
O BID acompanha o desenvolvimento econmico e social da América Latina e do Caribe, assim como as atividades do Banco.
Inter-American Development Bank
core   +1 more source

Learning Development and Education for Sustainability: what are the links? [PDF]

open access: yes, 2015
Learning Development (LD) is an emerging discipline developing a unique disciplinary identity. In common with many other new fields, it considers its position and relevance to other disciplines and bodies of thought, and in particular, educational ...
Graham Barton   +7 more
core   +1 more source

Development and validation of conflict management attitude questionnaire for medical students

open access: yesBMC Medical Education, 2022
Background Medical students should effectively manage conflicts in teamwork and communication with other team members. This study aimed to develop and validate a tool to evaluate attitude of medical students and physicians toward conflict management ...
Fatemeh Mohseni   +4 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

The IDB: Vol. 23, no. 8, August 1996

open access: yes, 1996
O BID acompanha o desenvolvimento econômico e social da América Latina e do Caribe, assim como as atividades do Banco.
Inter-American Development Bank
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The IDB: Vol. 23, no. 11, November 1996

open access: yes, 1996
O BID acompanha o desenvolvimento econmico e social da América Latina e do Caribe, assim como as atividades do Banco.
Inter-American Development Bank
core   +1 more source

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