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Angiogenesis in P- and E-Selectin-Deficient Mice
Microcirculation, 1998Several observations reported earlier indicated that the selectins, in particular E-selectin, might be involved in angiogenesis; however, mice deficient in the endothelial selectins develop normally. To clarify the role of endothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin-deficient mice.Hydron ...
D W, Hartwell +6 more
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Transcriptional Arrest of the Human E-Selectin Gene
Journal of Surgical Research, 1999E-selectin transcription requires binding of transcription factors, NF-kappaB, ATF-2, and HMG-I(Y). Here we characterize the mechanism responsible for the transcriptional downregulation of E-selectin expression.Human umbilical vein endothelial cells (HUVECs) were treated with TNF-alpha for 24 h. HUVEC E-selectin expression was measured by enzyme-linked
E M, Boyle +4 more
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The Journal of Immunology, 1994
Abstract E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1), is transiently expressed on endothelial cells in response to inflammatory cytokines such as IL-1 and TNF-alpha and mediates adhesion of leukocytes. The genomic structure of E-selectin is highly conserved and includes multiple polyadenylation signals
W, Chu +3 more
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Abstract E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1), is transiently expressed on endothelial cells in response to inflammatory cytokines such as IL-1 and TNF-alpha and mediates adhesion of leukocytes. The genomic structure of E-selectin is highly conserved and includes multiple polyadenylation signals
W, Chu +3 more
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2007
P- and E-selectin, commonly referred to as the “endothelial” selectins, were initially described and characterized in the mid-late 1980s. P-selectin was first identified in 1984, using antibodies raised against activated platelets [1, 2]. In these initial publications, P-selectin was described as a protein of molecular weight of approximately 140 000 ...
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P- and E-selectin, commonly referred to as the “endothelial” selectins, were initially described and characterized in the mid-late 1980s. P-selectin was first identified in 1984, using antibodies raised against activated platelets [1, 2]. In these initial publications, P-selectin was described as a protein of molecular weight of approximately 140 000 ...
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E-Selectin, Internalization and Release
1993E-selectin also designated ELAM-1/LECAM2 (1) is a 115kD membrane glycoprotein (2) which is induced on human endothelial cells by TNF, IL-1 and bacterial LPS (2–5). E-selectin is engaged in the adherence of neutrophil granulocytes, a subpopulation of monocytes and T-cells (2,6–9).
W. A. Buurman +2 more
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Expression of E-selectin in the human kidney
Nephrology Dialysis Transplantation, 1993A A, Pall +7 more
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